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Skin Mastocytoma

Subscribe to New Research on Skin Mastocytoma

A variant of cutaneous mastocytosis which occurs as a single lesion usually in infants. It is found mostly in the wrist and trunk and there is no atypical cytomorphology.

Also Known As:

Mastocytoma, Skin; Solitary Mastocytoma of Skin

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Disease Context: Research Results

Neoplasms: 649836
- Neoplasms by Histologic Type: 1
  - Connective and Soft Tissue Neoplasms
    - Connective Tissue Neoplasms: 6
      - Mastocytosis: 639
        Mastocytoma: 929
        Skin Mastocytoma: 3
        Cutaneous Mastocytosis: 83
        Skin Mastocytoma: 3
Skin and Connective Tissue Diseases
- Skin Diseases: 8226
  - Mastocytosis: 639
    - Mastocytoma: 929
      - Skin Mastocytoma: 3
    - Cutaneous Mastocytosis: 83
      - Skin Mastocytoma: 3

Related Diseases

1.	Urticaria Pigmentosa
2.	Mastocytosis (Mast-Cell Disease)
3.	Leukemia

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Skin Mastocytoma:

1.	Tryptases (Tryptase)IBA 01/01/1989 - "The substrate-hydrolyzing and inhibition properties for tryptase activity in involved and non-involved psoriatic skin sections were identical with each other as well as with those previously described in normal human skin or mastocytoma skin sections. " 01/01/1988 - "Immunoperoxidase and enzyme-histochemical demonstration of human skin tryptase in cutaneous mast cells in normal and mastocytoma skin." 09/01/1998 - "By contrast, tryptase, Giemsa, and CAE produced diagnostic staining of MCs in virtually all cases of systemic indolent mastocytosis, urticaria pigmentosa, and solitary skin mastocytoma. " 09/01/1998 - "To assess the diagnostic value of tryptase staining in mastocytosis, tissue sections from 93 patients with mastocytosis, including MM (n = 37), systemic indolent mastocytosis (n = 47), urticaria pigmentosa (n = 5), MC leukemia (n = 2), and solitary skin mastocytoma (n = 2) were stained with the antitryptase antibody G3. " 01/01/1988 - "The best substrate was Z-Gly-Pro-Arg-MNA giving the strongest red azo dye when incubation time was 15, 30 or 60 min. These results show the localization of human skin tryptase in dermal mast cells and the usefulness of Z-Gly-Pro-Arg-MNA as a suitable substrate tested for enzyme-histochemical localization of mast cells in healthy or mastocytoma skin."
2.	N-benzyloxycarbonylglycineIBA 01/01/1988 - "The best substrate was Z-Gly-Pro-Arg-MNA giving the strongest red azo dye when incubation time was 15, 30 or 60 min. These results show the localization of human skin tryptase in dermal mast cells and the usefulness of Z-Gly-Pro-Arg-MNA as a suitable substrate tested for enzyme-histochemical localization of mast cells in healthy or mastocytoma skin."
3.	prolylarginineIBA 01/01/1988 - "The best substrate was Z-Gly-Pro-Arg-MNA giving the strongest red azo dye when incubation time was 15, 30 or 60 min. These results show the localization of human skin tryptase in dermal mast cells and the usefulness of Z-Gly-Pro-Arg-MNA as a suitable substrate tested for enzyme-histochemical localization of mast cells in healthy or mastocytoma skin."
4.	tranilast (N 5')IBA 09/01/1998 - "To assess the diagnostic value of tryptase staining in mastocytosis, tissue sections from 93 patients with mastocytosis, including MM (n = 37), systemic indolent mastocytosis (n = 47), urticaria pigmentosa (n = 5), MC leukemia (n = 2), and solitary skin mastocytoma (n = 2) were stained with the antitryptase antibody G3. "