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Non-Receptor Type 2 Protein Tyrosine Phosphatase

A subtype of non-receptor protein tyrosine phosphatase that is closely-related to PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1. Alternative splicing of the mRNA for this phosphatase results in the production at two gene products, one of which includes a C-terminal nuclear localization domain that may be involved in the transport of the protein to the CELL NUCLEUS. Although initially referred to as T-cell protein tyrosine phosphatase the expression of this subtype occurs widely.
Also Known As:
Protein Tyrosine Phosphatase, Non-Receptor Type 2; Protein Tyrosine Phosphatase, Non-Receptor Type 2, TC45 Isoform; Protein Tyrosine Phosphatase, Non-Receptor Type 2, TC48 Isoform; T-Cell Protein Tyrosine Phosphatase; TC-PTP; TC45 Enzyme; TC45 Protein Tyrosine Phosphatase; TC48 Enzyme; TC48 Protein Tyrosine Phosphatase; TCPTP Enzyme; Protein Tyrosine Phosphatase, Non Receptor Type 2; T Cell Protein Tyrosine Phosphatase
Networked: 99 relevant articles (3 outcomes, 12 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Tremblay, Michel L: 15 articles (01/2021 - 05/2004)
2. Scharl, Michael: 12 articles (01/2021 - 12/2010)
3. McCole, Declan F: 10 articles (01/2021 - 12/2010)
4. Spalinger, Marianne R: 9 articles (01/2021 - 01/2015)
5. Rogler, Gerhard: 7 articles (01/2018 - 05/2012)
6. Doody, Karen M: 6 articles (03/2012 - 05/2007)
7. Krishnan, Moorthy: 5 articles (01/2021 - 11/2013)
8. Kim, Dae Joon: 5 articles (01/2020 - 01/2015)
9. Morales, Liza D: 5 articles (01/2020 - 01/2015)
10. Atrott, Kirstin: 4 articles (01/2021 - 01/2013)

Related Diseases

1. AIDS-Related Complex (ARC)
01/01/2020 - "Both the SL and LL groups at postnatal day 60 (PN60) exhibited increased levels of plasma leptin, the Lee index (as an index of obesity), adiposity content, immunoreactivity toward T-cell protein tyrosine phosphatase (TCPTP), and glial fibrillary acidic protein (GFAP) in the arcuate nucleus (ARC) of the hypothalamus. "
04/01/2014 - "SIRT1 improved leptin sensitivity in hypothalamic neurons in vitro and in vivo by downregulating protein-tyrosine phosphatase 1B, T cell protein-tyrosine phosphatase and suppressor of cytokine signalling 3. However, these phenotypes were absent in mice consuming a high-fat, high-sucrose diet due to decreases in ARC SIRT1 protein and hypothalamic NAD(+) levels. "
01/01/2019 - "This study evaluated the effects of ADX on ICV (lateral ventricle) injection of insulin-induced changes on food intake, mRNA expression of hypothalamic neuropeptides (insulin receptor (InsR), proopiomelanocortin, cocaine and amphetamine-regulated transcript (Cart), agouti-related protein, neuropeptide Y (Npy) in the arcuate nucleus of the hypothalamus (ARC), corticotrophin-releasing factor in the paraventricular nucleus of the hypothalamus) and hypothalamic protein content of insulin signaling-related molecules (insulin receptor substrate (IRS) 1, protein kinase B (AKT), extracellular-signal-regulated kinase (ERK1/2), c-Jun N-terminal kinase (JNK), protein tyrosine phosphatase-1B (PTP1B) and T cell protein tyrosine phosphatase (TCPTP)) Compared with sham animals, ADX increased the hypothalamic content of pJNK/JNK, PTP1B and TCPTP, as well as decreased mRNA expression of InsR, and corticosterone (B) treatment reversed these effects. "
2. Insulin Resistance
3. Body Weight (Weight, Body)
4. Pancreatitis
5. Hyperinsulinism (Hyperinsulinemia)

Related Drugs and Biologics

1. Proteins (Proteins, Gene)
2. Non-Receptor Type 1 Protein Tyrosine Phosphatase
3. Cytokines
4. Leptin
5. Glucose (Dextrose)
6. Sirtuin 1
7. Sucrose (Saccharose)
8. NAD (NADH)
9. Ceruletide
10. Non-Receptor Type 2 Protein Tyrosine Phosphatase

Related Therapies and Procedures

1. Immunotherapy
2. Therapeutics