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Takotsubo Cardiomyopathy

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A transient left ventricular apical dysfunction or ballooning accompanied by electrocardiographic (ECG) T wave inversions. This abnormality is associated with high levels of CATECHOLAMINES, either administered or endogenously secreted from a tumor or during extreme stress.

Also Known As:

Apical Ballooning Syndrome; Broken Heart Syndrome; Left Ventricular Apical Ballooning Syndrome; Stress Cardiomyopathy; Tako-tsubo Cardiomyopathy; Tako-tsubo Syndrome; Takotsubo Syndrome; Transient Apical Ballooning Syndrome; Cardiomyopathy, Stress; Cardiomyopathy, Tako-tsubo; Cardiomyopathy, Takotsubo; Syndrome, Apical Ballooning; Syndrome, Broken Heart; Syndrome, Tako-tsubo; Syndromes, Broken Heart; Syndromes, Tako-tsubo; Tako tsubo Cardiomyopathy; Tako tsubo Syndrome; Tako-tsubo Syndromes

Networked: 523 relevant articles (4 outcomes, 16 trials/studies)

Relationship Network

Disease Context: Research Results

Cardiovascular Diseases: 37259
- Heart Diseases: 18762
  - Ventricular Dysfunction: 819
    - Left Ventricular Dysfunction: 3433
      - Takotsubo Cardiomyopathy: 523
        Transient antero-apical dyskinesia: 1

Related Diseases

1.	Cardiogenic Shock
2.	Myocardial Stunning (Stunned Myocardium)
3.	Heart Arrest (Cardiac Arrest)
4.	Coronary Stenosis (Coronary Artery Stenosis)
5.	Takotsubo Cardiomyopathy

Experts

1.	Madias, John E: 31 articles (01/2016 - 07/2013)
2.	Brunetti, Natale Daniele: 7 articles (02/2015 - 05/2013)
3.	Di Biase, Matteo: 7 articles (02/2015 - 05/2013)
4.	Santoro, Francesco: 7 articles (02/2015 - 05/2013)
5.	Borggrefe, Martin: 7 articles (01/2014 - 01/2005)
6.	Prasad, Abhiram: 7 articles (06/2012 - 03/2006)
7.	Finsterer, Josef: 5 articles (12/2014 - 10/2007)
8.	Stöllberger, Claudia: 5 articles (12/2014 - 10/2007)
9.	Nef, Holger M: 5 articles (11/2014 - 02/2008)
10.	Ferraretti, Armando: 5 articles (07/2014 - 05/2013)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Takotsubo Cardiomyopathy:

1.	Dopamine (Intropin)FDA LinkGeneric 05/14/2010 - "The present case report suggests that the administration of dopamine may lead to further hemodynamic deterioration in patients with takotsubo cardiomyopathy who exhibits an IVPG." 05/14/2010 - "We report a patient with takotsubo cardiomyopathy in whom cardiogenic shock continued with a high intraventricular pressure gradient (IVPG) under a high-dose intravenous administration of dopamine and in whom cessation of the administration improved the hemodynamics dramatically. " 05/14/2010 - "Prolonged cardiogenic shock caused by a high-dose intravenous administration of dopamine in a patient with takotsubo cardiomyopathy." 07/01/2014 - "In response to "Postoperative Takotsubo syndrome": The role of atropine, dopamine and noradrenaline in the management of Takotsubo syndrome."
2.	CatecholaminesIBA 09/01/2012 - "Several studies have shown a link between takotsubo cardiomyopathy and elevated catecholamines. " 04/14/2009 - "The aim of this study was to report a series of patients with stress cardiomyopathy precipitated by the intravenous administration of catecholamines and beta-receptor agonists. " 06/15/2015 - "The causal link between the blood borne catecholamines and takotsubo syndrome: Too many flaws." 05/01/2015 - "Blood borne catecholamines and Takotsubo syndrome: An unsettled relationship." 06/01/2014 - "Increased level of serum catecholamines in the acute phase was reported to be a feature of takotsubo cardiomyopathy (TC). "
3.	Dobutamine FDA LinkGeneric 03/01/2007 - "Functional derangement and cardiac innervation in the apical ballooning syndrome: a 123I-meta-iodobenzylguanidine scintigraphic and dobutamine stress echocardiographic study." 12/15/2015 - "Reduced dobutamine stress test-based coronary flow reserve in patients with Takotsubo syndrome: An innate substrate or a lingering effect?" 10/01/2015 - "Dobutamine was more frequently used in patients with stress cardiomyopathy. " 05/01/2015 - "The mechanism of mid-variant of Dobutamine-induced stress cardiomyopathy remains unclear. " 05/01/2015 - "Mid-Ventricular Variant of Dobutamine-Induced Stress Cardiomyopathy."
4.	Epinephrine (Adrenaline)FDA LinkGeneric 11/19/2010 - "Takotsubo cardiomyopathy after nasal application of epinephrine--a magnetic resonance study." 12/01/2015 - "Fatal Takotsubo cardiomyopathy due to epinephrine in shoulder arthroscopy." 03/01/2015 - "Is the worse outcome associated with epinephrine in resuscitated patients due to Takotsubo syndrome?" 01/01/2015 - "A novel miR-371a-5p-mediated pathway, leading to BAG3 upregulation in cardiomyocytes in response to epinephrine, is lost in Takotsubo cardiomyopathy." 12/01/2014 - "Takotsubo cardiomyopathy following an injection of epinephrine remains a rare but increasingly described occurrence. "
5.	TroponinIBA 01/01/2009 - "In the present study, reported cases of stress cardiomyopathy were compared with documented cardiac enzyme levels to evaluate the upper cut-off point of troponin in this population. " 06/26/2015 - "Electrocardiogram (ECG), elevation of troponin and echocardiographic findings were consistent with inverted Takotsubo cardiomyopathy. " 04/01/2013 - "Troponin elevation in aortic dissection patients may be due to takotsubo cardiomyopathy: aortic dissection vs takotsubo cardiomyopathy." 10/18/2012 - "Troponin elevation during exacerbations of chronic obstructive airways disease due to stress cardiomyopathy." 04/01/2012 - "Release patterns of copeptin and troponin in Tako-Tsubo cardiomyopathy."
6.	Adrenergic Receptors (Adrenergic Receptor)IBA 12/01/2011 - "The aim of our study was to analyse the frequency of beta1 and/or beta2 adrenergic receptor polymorphisms in patients with takotsubo cardiomyopathy (TTC). " 01/01/2014 - "This report highlights the risk of developing Takotsubo cardiomyopathy following ECT despite β-adrenergic receptor blockade, and adds to a growing number of cases reporting this complication. " 08/01/2012 - "People taking outpatient β-adrenergic receptor antagonist therapy have less-severe presentation and clinical course of Takotsubo cardiomyopathy. " 02/01/2009 - "Adrenergic receptor polymorphisms in patients with stress (tako-tsubo) cardiomyopathy." 12/01/2008 - "Immobilization (IMO) stress of rats can reproduce the electrocardiographic and left ventriculographic changes that occur in takotsubo cardiomyopathy, both of which are prevented by combined blockade of alpha- and beta-adrenoceptors. "
7.	GadoliniumIBA 01/01/2011 - "Our study aimed to investigate both the clinical implications of late gadolinium enhancement (LGE) by cardiovascular magnetic resonance (CMR) and the relation of LGE to clinical findings in patients with Takotsubo cardiomyopathy (TTC). " 07/01/2014 - "Increased ventricular wall stress and late gadolinium enhancement in Takotsubo cardiomyopathy." 05/01/2014 - "Ventricular wall stress and late gadolinium enhancement in patients with Takotsubo syndrome: more data worth contemplating about." 01/01/2014 - "Increased ventricular wall stress and late gadolinium enhancement in Takotsubo cardiomyopathy." 01/01/2012 - "To determine the prevalence and signal intensity (SI) characteristics of late gadolinium enhancement (LGE) on magnetic resonance imaging (MRI) in takotsubo cardiomyopathy (TC). "
8.	HormonesIBA 06/01/2012 - "Clinical characteristics, sex hormones, and long-term follow-up in Swiss postmenopausal women presenting with Takotsubo cardiomyopathy." 05/01/2009 - "The relationship of thyroid hormone status with myocardial function in stress cardiomyopathy." 01/01/2011 - "Takotsubo cardiomyopathy in a patient with severe hyponatremia associated with syndrome of inappropriate antidiuretic hormone." 05/01/2009 - "This study aimed to investigate thyroid hormone (TH) status and its relationship with myocardial function as well as clinical and biochemical parameters in stress cardiomyopathy (CMP). " 09/01/2009 - "Stress hormone and circulating biomarker profile of apical ballooning syndrome (Takotsubo cardiomyopathy): insights into the clinical significance of B-type natriuretic peptide and troponin levels."
9.	Cytidine Monophosphate (CMP)IBA 12/01/2013 - "The main hallmark of Takotsubo cardiomyopathy (TT-CMP) is transient ischaemia, with completely reversible regional contractile dysfunction, which involves the mid-apical segments and shows no angiographic signs of coronary artery disease (CAD). " 05/01/2009 - "This study aimed to investigate thyroid hormone (TH) status and its relationship with myocardial function as well as clinical and biochemical parameters in stress cardiomyopathy (CMP). " 06/01/2010 - "Stress cardiomyopathy (CMP) has been described as a complication of post-myocardial infarction pericarditis (Dressler syndrome). "
10.	Calcium Channel Blockers (Blockers, Calcium Channel)IBA 08/15/2015 - "Impact of Brain Natriuretic Peptide, Calcium Channel Blockers, and Body Mass Index on Recovery Time from Left Ventricular Systolic Dysfunction in Patients With Takotsubo Cardiomyopathy." 05/29/2009 - "Tako-tsubo cardiomyopathy can occur despite treatment with calcium channel blockers, nitrates or beta-blockers, suggesting limitation of these medications to prevent tako-tsubo cardiomyopathy." 01/09/2009 - "Although the current study demonstrates that the use of beta-blockers, aspirin, ACE inhibitors and calcium channel blockers does not seem to be indicated for chronic treatment of Takotsubo cardiomyopathy, we strongly believe that we need to achieve the data which will be obtained from large scale prospective studies in the near future to assess the clinical significance of chronic medical treatment."

Therapies and Procedures

1.	General Anesthesia 08/01/2015 - "[Development of Takotsubo Cardiomyopathy during Recovery from General Anesthesia: A Case Report]." 08/01/2011 - "[Case of Takotsubo cardiomyopathy after induction of general anesthesia]." 04/01/2010 - "A case of paradoxical embolization and subsequent Takotsubo cardiomyopathy during general anesthesia." 03/01/2010 - "The authors discuss and present transesophageal echocardiographic images of intraoperative tako-tsubo cardiomyopathy in a female patient under general anesthesia. " 05/01/2007 - "Takotsubo cardiomyopathy after general anesthesia."
2.	Drug Therapy (Chemotherapy) 07/01/2014 - "Lack of efficacy of drug therapy in preventing takotsubo cardiomyopathy recurrence: a meta-analysis." 02/16/2015 - "Is Takotsubo syndrome in patients receiving chemotherapy drug-specific?" 10/16/2014 - "Chemotherapy has been linked with Takotsubo cardiomyopathy. " 10/16/2014 - "Chemotherapy induced Takotsubo cardiomyopathy." 04/01/2013 - "Chemotherapy-induced takotsubo cardiomyopathy is a relatively new phenomenon, but one that merits detailed attention to the elucidation of possible mechanistic links."
3.	Intra-Aortic Balloon Pumping 07/01/2004 - "[Intra-aortic balloon pumping is effective for hemodynamic management of catecholamine resistant ampulla (Takotsubo) cardiomyopathy]."
4.	Laparoscopic Cholecystectomy 12/01/2007 - "We report a case of Tako-tsubo cardiomyopathy that ensued immediately after induction of general anaesthesia for elective surgery in a patient submitted to laparoscopic cholecystectomy. " 06/01/2010 - "The aim of this study was to describe the clinical features and management of Takotsubo cardiomyopathy manifesting during the intraoperative period in a patient undergoing laparoscopic cholecystectomy. "
5.	Nursing Care 03/02/1983 - "Nursing care study: the 'broken heart syndrome' and the elderly patient."