Group V Phospholipases A2

A subcategory of secreted phospholipases A2 that contains both a negatively charged carboxy-terminal segment and interfacial-binding region specific for PHOSPHATIDYL CHOLINE-containing membranes. This enzyme group may play a role in the release of ARACHIDONIC ACID from phospholipid membranes.

Also Known As:

Networked: 13 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Balestrieri, Barbara: 4 articles (01/2016 - 05/2010)
2.	Webb, Nancy R: 3 articles (09/2012 - 07/2006)
3.	Fujioka, Daisuke: 3 articles (05/2011 - 05/2010)
4.	Boyce, Joshua A: 2 articles (06/2013 - 10/2010)
5.	Xing, Wei: 2 articles (06/2013 - 10/2010)
6.	Gelb, Michael H: 2 articles (01/2013 - 05/2010)
7.	Lai, Ying: 2 articles (01/2013 - 05/2010)
8.	Boyanovsky, Boris B: 2 articles (09/2012 - 03/2007)
9.	de Beer, Frederick C: 2 articles (03/2007 - 07/2006)
10.	Asatryan, Liana: 1 article (06/2016)

Related Diseases

1.	Abdominal Aortic Aneurysm 09/01/2012 - "Group V secretory phospholipase A2 enhances the progression of angiotensin II-induced abdominal aortic aneurysms but confers protection against angiotensin II-induced cardiac fibrosis in apoE-deficient mice."
2.	Fibrosis (Cirrhosis) 09/01/2012 - "Group V secretory phospholipase A2 enhances the progression of angiotensin II-induced abdominal aortic aneurysms but confers protection against angiotensin II-induced cardiac fibrosis in apoE-deficient mice."
3.	Retinal Degeneration 08/01/2013 - "Results from the present study suggest that Group V sPLA2 has multiple intracellular targets during iron-induced retinal degeneration and that the specific role of sPLA2 could be related to inflammatory responses by its participation in NF-κB and COX-2 regulation."
4.	Inflammation (Inflammations) 01/01/2016 - "Group V secretory phospholipase A2 is necessary for the development of M2 macrophages and their effector functions in a mouse model of the T-helper-2 allergic airway inflammation. " 07/01/2006 - "Inflammation and atherosclerosis: Group IIa and Group V sPLA2 are not redundant." 05/01/2010 - "These observations identify a novel anti-inflammatory function for a PLA2 and identify group V sPLA2 as a potential biotherapeutic for treatment of immune-complex-mediated inflammation."
5.	Atherosclerosis 03/01/2007 - "Group v secretory phospholipase A2 promotes atherosclerosis: evidence from genetically altered mice." 07/01/2006 - "Inflammation and atherosclerosis: Group IIa and Group V sPLA2 are not redundant."

Related Drugs and Biologics

1.	Apolipoproteins E (ApoE)
2.	Angiotensin II
3.	Secretory Phospholipases A2
4.	Iron
5.	Group X Phospholipases A2
6.	Cytokines
7.	Protein C
8.	Antigen-Antibody Complex (Immune Complex)
9.	Endothelial Protein C Receptor