Group IB Phospholipases A2

A subclass of group I phospholipases A2 that includes enzymes isolated from PANCREATIC JUICE. Members of this group have specificity for PHOSPHOLIPASE A2 RECEPTORS.

Also Known As:

Group IB Secretory Phospholipase A(2); Group IB Secretory Phospholipase A2; sPLA(2)-IB; sPLA2-IB; Phospholipases A2, Group IB

Networked: 14 relevant articles (1 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Esterases: 1574
      - Carboxylic Ester Hydrolases: 62
        Phospholipases: 2589
        Phospholipases A: 58
        Phospholipases A2: 2075
        Secretory Phospholipases A2: 751
        Group I Phospholipases A2
        Group IB Phospholipases A2: 14
        Arabidopsis phospholipase A2 gamma
        human PLA2G1B protein
        mouse Pla2g1b protein
        rat Pla2g1b protein

Experts

1.	Chen, Hong: 2 articles (01/2021 - 08/2020)
2.	Pan, Yangbin: 2 articles (01/2021 - 10/2014)
3.	Tao, Xuan: 2 articles (01/2021 - 08/2020)
4.	Wan, Jianxin: 2 articles (01/2021 - 10/2014)
5.	Dai, Binbin: 1 article (01/2021)
6.	Li, Guoping: 1 article (01/2021)
7.	Lin, Songhua: 1 article (01/2021)
8.	Wu, Yuansheng: 1 article (01/2021)
9.	Yang, Liyan: 1 article (01/2021)
10.	Dai, Bin-Bin: 1 article (08/2020)

Related Diseases

1.	Proteinuria 08/01/2020 - "IMN patients with lower sPLA2-IB and proteinuria levels were found to have better outcome after the 6-month follow-up. " 01/01/2021 - "We found that IMN patients with nephrotic-range proteinuria have a significantly higher level of sPLA2-IB and fewer autophagosomes than those with non-nephrotic-range proteinuria. " 01/01/2021 - "The serum sPLA2-IB level and podocyte autophagy were detected, and clinical data were collected from IMN patients with different proteinuria levels. " 08/01/2020 - "The levels of serum sPLA2-IB, lipemia and proteinuria were measured. " 08/01/2020 - "In conclusion, serum sPLA2-IB was closely correlated with proteinuria, albumin and cholesterol, and IMN patients with lower sPLA2-IB levels were more likely to achieve a better outcome."
2.	Hyperlipidemias (Hyperlipidemia) 08/01/2020 - "The present study aimed to investigate the correlation between sPLA2-IB and lipemia, and the clinical merit of sPLA2-IB in the prediction of prognosis of IMN patients. " 08/01/2020 - "However, the interference of high lipemia on the sPLA2-IB levels was not taken into account in these studies. " 08/01/2020 - "The levels of serum sPLA2-IB, lipemia and proteinuria were measured. " 08/01/2020 - "sPLA2-IB Level Correlates with Hyperlipidemia and the Prognosis of Idiopathic Membranous Nephropathy."
3.	Glomerulonephritis 10/01/2006 - "In the current study, we have investigated the expression and regulation of sPLA(2)-IB and its receptor during glomerulonephritis (GN). "
4.	Fibrosarcoma 01/01/2008 - "Correspondingly, adding an exogenous sPLA2-IB (but not IIA) resulted in significant elevation of MMP-2/9 secretion from the fibrosarcoma cells. " 01/01/2008 - "MMP production in human fibrosarcoma cells and their invasiveness are regulated by group IB secretory phospholipase A2 receptor-mediated activation of cytosolic phospholipase A2." 01/01/2008 - "The results of this study show for the first time that MMP-2/9 production by human fibrosarcoma HT-1080 cells and their invasiveness is regulated by sPLA2-IB acting as a receptor ligand to activate cPLA2, which in turn provides the AA for production of eicosanoids required for MMP expression."
5.	Membranous Glomerulonephritis (Membranous Nephropathy) 01/01/2021 - "sPLA2-IB and PLA2R mediate insufficient autophagy and contribute to podocyte injury in idiopathic membranous nephropathy by activation of the p38MAPK/mTOR/ULK1ser757 signaling pathway." 08/01/2020 - "sPLA2-IB Level Correlates with Hyperlipidemia and the Prognosis of Idiopathic Membranous Nephropathy."

Related Drugs and Biologics

1.	Cholesterol
2.	Albumins
3.	Ligands
4.	Matrix Metalloproteinases (MMPs)
5.	Eicosanoids
6.	Group IB Phospholipases A2
7.	Secretory Phospholipases A2
8.	Lipase (Acid Lipase)
9.	Amylases
10.	Group X Phospholipases A2