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Peroxiredoxins

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A family of ubiquitously-expressed peroxidases that play a role in the reduction of a broad spectrum of PEROXIDES like HYDROGEN PEROXIDE; LIPID PEROXIDES and peroxinitrite. They are found in a wide range of organisms, such as BACTERIA; PLANTS; and MAMMALS. The enzyme requires the presence of a thiol-containing intermediate such as THIOREDOXIN as a reducing cofactor.

Also Known As:

Alkyl Hydroperoxide Reductase; Alkyl Hydroperoxide Reductase C; Alkyl Hydroperoxide Reductase D; Alkylhydroperoxide Reductase; Mitochondrial Thioredoxin-Dependent Antioxidant Protein SP-22; PRDX3 Peroxidase; Peroxidoxin; Peroxiredoxin 1; Peroxiredoxin 2; Peroxiredoxin 3; Peroxiredoxin 4; Peroxiredoxin 5; Peroxiredoxin I; Peroxiredoxin II; Peroxiredoxin III; Peroxiredoxin IV; Peroxiredoxin V; Peroxiredoxin-4; Protector Protein (Mixed-Function Oxidase Systems); Thiol-Specific Antioxidant Protein; Thioredoxin Peroxidase; Thioredoxin Peroxidase 1; Thioredoxin Peroxidase 2; Thioredoxin Peroxidase PMP20; Thioredoxin-Dependent Peroxide Reductase 1; Thioredoxin-Dependent Peroxide Reductase 2; Hydroperoxide Reductase, Alkyl; Mitochondrial Thioredoxin Dependent Antioxidant Protein SP 22; Thiol Specific Antioxidant Protein; Thioredoxin Dependent Peroxide Reductase 1; Thioredoxin Dependent Peroxide Reductase 2; Peroxiredoxin

Networked: 495 relevant articles (7 outcomes, 42 trials/studies)

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Bio-Agent Context: Research Results

Experts

1.	Soini, Ylermi: 12 articles (12/2015 - 08/2003)
2.	Kinnula, Vuokko L: 9 articles (01/2013 - 03/2002)
3.	Yu, Dae-Yeul: 8 articles (01/2015 - 03/2007)
4.	Kang, Sang Won: 8 articles (10/2013 - 08/2003)
5.	Ishii, Tetsuro: 6 articles (11/2015 - 10/2009)
6.	Karihtala, Peeter: 6 articles (09/2015 - 08/2003)
7.	Lee, Dong-Seok: 6 articles (03/2015 - 03/2007)
8.	Hampton, Mark B: 6 articles (08/2013 - 03/2007)
9.	Rhee, Sue Goo: 6 articles (09/2012 - 12/2005)
10.	Yang, Hee-Young: 5 articles (01/2015 - 03/2007)

Related Diseases

1.	Neoplasms (Cancer) 02/01/2005 - "Studies of c-Abl(-/-) osteoblasts revealed that c-Abl played a negative role in the induction of peroxiredoxin I (Prx I, Prdx I), an anti-oxidant protein with tumor suppression activity. " 01/01/2016 - "Re: Peroxiredoxin 4: A Novel Secreted Mediator of Cancer Induced Osteoclastogenesis." 10/01/2015 - "We used immunohistochemistry and quantitative polymerase chain reaction to compare expression of mitochondrial peroxiredoxin 3 (PRX3) in CD133(+)CD44(+) Lgr5(+)cells (CSCs) vs CD133(-)CD44(-)Lgr5(-) colon tumor cells (non-CSCs). " 10/01/2015 - "The sulfiredoxin-peroxiredoxin (Srx-Prx) axis in cell signal transduction and cancer development." 06/01/2015 - "Using mass spectrometry, we identified peroxiredoxin (PRDX) as a secreted mediator of cancer-induced osteoclastogenesis. "
2.	Shock 03/19/2007 - "Roles of peroxiredoxin II in the regulation of proinflammatory responses to LPS and protection against endotoxin-induced lethal shock." 07/01/2013 - "annexin 11, peroxiredoxin 1, TrpRS), heat-shock/chaperone proteins (e.g. " 05/01/2008 - "Heat-shock protein-27, -70 and peroxiredoxin-II show molecular chaperone function in sickle red cells: Evidence from transgenic sickle cell mouse model." 10/15/2006 - "After hydrogen peroxide treatment or heat shock, peroxiredoxin was detected preferentially as dimers in metastatic L. " 10/01/2005 - "Western blot revealed that heat shock 60 kDa protein, catalase and peroxiredoxin 2 were also up-regulated. "
3.	Filarial Elephantiasis (Lymphatic Filariasis) 07/01/2012 - "Brugia malayi thioredoxin peroxidase as a potential vaccine candidate antigen for lymphatic filariasis." 02/01/2009 - "An attempt was made to study the immunoprophylactic efficacy of recombinant Brugia malayi transglutaminase (BmTGA) as protein vaccine along with two other recombinant proteins, Brugia malayi abundant larval transcript-2 (BmALT-2) and Brugia malayi thioredoxin peroxidase (BmTPX), in single and multiple antigen form for human lymphatic filariasis. " 06/01/2011 - "Although the antioxidant thioredoxin peroxidase (TPX) is a putative target exploited in vaccine studies of lymphatic filariasis, the high sequence homology with host peroxiredoxins remains a great concern. "
4.	Inflammation 08/01/2013 - "Neutrophil-mediated oxidation of erythrocyte peroxiredoxin 2 as a potential marker of oxidative stress in inflammation." 03/01/2013 - "[Peroxiredoxin triggers post-ischemic inflammation]." 01/01/2012 - "Peroxiredoxin 1 (Prx1) was recently identified as an endogenous ligand for TLR4 that is secreted from CaP cells and promotes inflammation. " 10/01/2009 - "Peroxiredoxin (Prx) I, a ubiquitous antioxidant enzyme, is known to protect against inflammation; however, its role in the allergic inflammation remains unidentified. " 01/01/2006 - "We characterized changes in expression of the antioxidant protein Peroxiredoxin V (PRXV) during airway inflammation. "
5.	Carcinoma (Carcinomatosis) 09/10/2006 - "Peroxiredoxin V is essential for protection against apoptosis in human lung carcinoma cells." 09/10/2006 - "The goal of our study was to determine the functional role of the novel antioxidant protein Peroxiredoxin V (PrxV), in protection of human lung carcinoma cell lines against apoptosis. " 06/01/2012 - "Downregulation of peroxiredoxin I by a novel fully human phage display recombinant antibody induces apoptosis and enhances radiation sensitization in A549 lung carcinoma cells." 01/01/2009 - "Overexpression of peroxiredoxin I and thioredoxin1 in human breast carcinoma." 05/01/2006 - "Oxidative/nitrosative stress and peroxiredoxin 2 are associated with grade and prognosis of human renal carcinoma."

Related Drugs and Biologics

1.	Reactive Oxygen Species (Oxygen Radicals)
2.	Antigens
3.	Ubiquitin
4.	Recombinant Proteins
5.	Peroxidase (Myeloperoxidase)
6.	Antibodies
7.	Nitric Oxide Synthase (NO Synthase)
8.	Interleukin-8 (Interleukin 8)
9.	Pulmonary Surfactants (Pulmonary Surfactant)
10.	Phosphoserine

Related Therapies and Procedures

1.	Homologous Transplantation (Allograft)
2.	Radiotherapy
3.	Drug Therapy (Chemotherapy)
4.	Heterologous Transplantation (Xenotransplantation)
5.	Caloric Restriction