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p21-Activated Kinases

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A family of serine-threonine kinases that bind to and are activated by MONOMERIC GTP-BINDING PROTEINS such as RAC GTP-BINDING PROTEINS and CDC42 GTP-BINDING PROTEIN. They are intracellular signaling kinases that play a role the regulation of cytoskeletal organization.

Also Known As:

Oligophrenin-3; PAK Kinases; PAK-1 Kinase; PAK-2 Kinase; PAK1 Kinase; PAK2 Kinase; PAK3 Kinase; PAK65; Serine-Threonine-Protein Kinase PAK 1; Serine-Threonine-Protein Kinase PAK 3; alpha p21-Activated Kinase; alpha-PAK; beta p21-Activated Kinase; beta-PAK; gamma-PAK; p21-Activated Kinase 1; p21-Activated Kinase 2; p21-Activated Kinase 3; p65(PAK); p65PAK Protein; Kinases, PAK; Kinases, p21-Activated; Oligophrenin 3; PAK 1 Kinase; PAK 2 Kinase; Serine Threonine Protein Kinase PAK 1; Serine Threonine Protein Kinase PAK 3; alpha p21 Activated Kinase; beta p21 Activated Kinase; gamma PAK; p21 Activated Kinase 1; p21 Activated Kinase 2; p21 Activated Kinase 3; p21 Activated Kinases; p21-Activated Kinase, beta

Networked: 124 relevant articles (1 outcomes, 10 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Kumar, Rakesh: 16 articles (07/2012 - 08/2002)
2.	Chernoff, Jonathan: 10 articles (02/2015 - 08/2002)
3.	Hoeflich, Klaus P: 7 articles (12/2015 - 04/2011)
4.	He, Hong: 6 articles (04/2015 - 09/2010)
5.	Baldwin, Graham S: 5 articles (04/2015 - 09/2010)
6.	Kumar, R: 5 articles (03/2008 - 11/2000)
7.	Vadlamudi, Ratna K: 5 articles (04/2005 - 08/2002)
8.	Rudolph, Joachim: 4 articles (12/2015 - 05/2013)
9.	Liu, Haiou: 4 articles (11/2015 - 07/2012)
10.	Gu, Jianxin: 4 articles (11/2015 - 07/2012)

Related Diseases

1.	Hepatocellular Carcinoma (Hepatoma) 11/20/2015 - "Our previous studies identified the oncogenic role of p21-activated kinase 1 (PAK1) in hepatocellular carcinoma (HCC) and renal cell carcinoma (RCC). " 01/01/2014 - "The role of p21-activated kinases in hepatocellular carcinoma metastasis." 09/01/2015 - "The aim of the present study is to understand the efficacy of a flavonoid myricetin for the first time in inhibiting the downstream target p21 activated kinase 1 (PAK1) of Ras signaling pathway in hepatocellular carcinoma. " 09/01/2015 - "Myricetin induces apoptosis by inhibiting P21 activated kinase 1 (PAK1) signaling cascade in hepatocellular carcinoma." 07/01/2012 - "Hepatitis B virus X protein confers resistance of hepatoma cells to anoikis by up-regulating and activating p21-activated kinase 1."
2.	Neoplasms (Cancer) 12/10/2015 - "Signaling pathways intersecting with the p21-activated kinases (PAKs) play important roles in tumorigenesis and cancer progression. " 11/01/2015 - "P21-activated kinase 1(PAK1) plays an important role in the regulation of cell morphogenesis, motility, mitosis, and angiogenesis and has been implicated with tumorigenesis and tumor progression. " 06/25/2015 - "The p21-activated kinases (PAKs) play important roles in cytoskeletal organization, cellular morphogenesis, and survival and have generated significant attention as potential therapeutic targets for cancer. " 04/01/2015 - "p21-Activated kinases can mediate many different cellular processes especially those contributing to cancer development and progression. " 06/01/2014 - "The p21-activated kinase 1 (PAK1) plays key roles in cellular processes including proliferation, survival, and motility, and in cell transformation and tumor progression. "
3.	Breast Neoplasms (Breast Cancer) 04/01/2008 - "Overexpression of p21-activated kinase 1 (PAK1) occurs during the progression of human breast cancer. " 04/01/2008 - "p21-Activated kinase 1 coordinates aberrant cell survival and pericellular proteolysis in a three-dimensional culture model for premalignant progression of human breast cancer." 04/15/2005 - "Since the invasiveness of breast cancer cells is also influenced by p21-activated kinase 1 (Pak1) signaling, we investigated Pak1's potential mechanistic role in the regulation of Snail functions. " 12/15/2000 - "Heregulin-beta1 promotes the activation of p21-activated kinase 1 (Pak1) and the motility and invasiveness of breast cancer cells. " 11/17/2000 - "We also provide evidence to suggest a close correlation between the status of Pak1 kinase activity and base-line invasiveness of human breast cancer cells and breast tumor grades. "
4.	Neoplasm Metastasis (Metastasis) 07/01/2010 - "Recent studies proved that P21-activated kinase 1 (PAK1) is highly expressed in many kinds of tumor and plays an important role in genesis, development, and metastasis of tumor. " 06/01/2015 - "P21-activated kinase 1 and 4 were associated with colorectal cancer metastasis and infiltration." 01/01/2014 - "The role of p21-activated kinases in hepatocellular carcinoma metastasis." 02/23/2012 - "P21-activated kinase 1 (PAK1) is associated with colon cancer progression and metastasis, whereas the molecular mechanism remains elusive. " 01/01/2014 - "The p21-activated kinases (PAKs) are downstream effectors of the Rho family small GTPases as well as a wide variety of mitogenic factors and have been implicated in cancer formation, development and metastasis. "
5.	Cardiomegaly (Heart Hypertrophy) 12/13/2011 - "In this study, we identified p21-activated kinase 1 (Pak1) as a novel signaling regulator that antagonizes cardiac hypertrophy. " 01/01/2014 - "Inhibition of angiotensin II-induced cardiac hypertrophy and associated ventricular arrhythmias by a p21 activated kinase 1 bioactive peptide." 12/03/2010 - "Therefore, in seeking the etiology of this MAP4 dephosphorylation, we looked here at PP2A and PP1, as well as the upstream p21-activated kinase 1, in maladaptive pressure overload cardiac hypertrophy. "

Related Drugs and Biologics

1.	myricetin
2.	gefitinib (Iressa)
3.	Monomeric GTP-Binding Proteins
4.	Tamoxifen
5.	Protein Kinases (Protein Kinase)
6.	Interleukins
7.	Interleukin-10 Receptors
8.	Zinc
9.	Iron
10.	Interferons

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