HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

rho-Associated Kinases

A group of intracellular-signaling serine threonine kinases that bind to RHO GTP-BINDING PROTEINS. They were originally found to mediate the effects of rhoA GTP-BINDING PROTEIN on the formation of STRESS FIBERS and FOCAL ADHESIONS. Rho-associated kinases have specificity for a variety of substrates including MYOSIN-LIGHT-CHAIN PHOSPHATASE and LIM KINASES.
Also Known As:
ROCK Protein Kinases; ROCK-I Protein Kinase; ROCK-II Protein Kinase; ROK Kinase; p160 rhoA-Binding Kinase ROKalpha; p160ROCK; rho-Associated Coiled-Coil Containing Protein Kinase 1; rho-Associated Coiled-Coil Containing Protein Kinase 2; rho-Associated Coiled-Coil Kinase; rho-Associated Kinase 1; rho-Associated Kinase 2; rho-Associated Kinase alpha; rho-Associated Kinase beta; rho-Associated Protein Kinase alpha; rho-Associated Protein Kinase beta; rho-Kinase; Coiled-Coil Kinase, rho-Associated; Protein Kinases, ROCK; ROCK I Protein Kinase; ROCK II Protein Kinase; p160 rhoA Binding Kinase ROKalpha; rho Associated Coiled Coil Containing Protein Kinase 1; rho Associated Coiled Coil Containing Protein Kinase 2; rho Associated Coiled Coil Kinase; rho Associated Kinase; rho Associated Kinase 1; rho Associated Kinase 2; rho Associated Kinase alpha; rho Associated Kinase beta; rho Associated Kinases; rho Associated Protein Kinase alpha; rho Associated Protein Kinase beta; rho Kinase; rho-Associated Kinase
Networked: 2032 relevant articles (131 outcomes, 316 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Shimokawa, Hiroaki: 78 articles (12/2019 - 02/2002)
2. Liao, James K: 37 articles (01/2020 - 07/2002)
3. Kaibuchi, Kozo: 24 articles (11/2019 - 02/2002)
4. Fukumoto, Yoshihiro: 22 articles (06/2014 - 01/2004)
5. Li, Tao: 21 articles (10/2022 - 06/2006)
6. Takeshita, Akira: 19 articles (03/2007 - 02/2002)
7. Calò, Lorenzo A: 15 articles (01/2022 - 10/2004)
8. Noma, Kensuke: 15 articles (01/2019 - 05/2003)
9. Liu, Liangming: 15 articles (10/2017 - 06/2005)
10. Shimokawa, H: 15 articles (10/2007 - 01/2000)

Related Diseases

1. Fibrosis (Cirrhosis)
2. Inflammation (Inflammations)
3. Pulmonary Hypertension
4. Hypertension (High Blood Pressure)
5. Glaucoma

Related Drugs and Biologics

1. fasudil (AT 877)
2. Y 27632
3. K-115
4. Monocrotaline
5. Proteins (Proteins, Gene)
6. hydroxyfasudil
7. Monomeric GTP-Binding Proteins
8. Glucose (Dextrose)
9. Nitric Oxide (Nitrogen Monoxide)
10. netarsudil

Related Therapies and Procedures

1. Therapeutics
2. Oral Administration
3. Ligation
4. Intravitreal Injections
5. Cardiopulmonary Resuscitation (CPR)