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rho-Associated Kinases

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A group of intracellular-signaling serine threonine kinases that bind to RHO GTP-BINDING PROTEINS. They were originally found to mediate the effects of rhoA GTP-BINDING PROTEIN on the formation of STRESS FIBERS and FOCAL ADHESIONS. Rho-associated kinases have specificity for a variety of substrates including MYOSIN-LIGHT-CHAIN PHOSPHATASE and LIM KINASES.

Also Known As:

ROCK Protein Kinases; ROCK-I Protein Kinase; ROCK-II Protein Kinase; ROK Kinase; p160 rhoA-Binding Kinase ROKalpha; p160ROCK; rho-Associated Coiled-Coil Containing Protein Kinase 1; rho-Associated Coiled-Coil Containing Protein Kinase 2; rho-Associated Coiled-Coil Kinase; rho-Associated Kinase 1; rho-Associated Kinase 2; rho-Associated Kinase alpha; rho-Associated Kinase beta; rho-Associated Protein Kinase alpha; rho-Associated Protein Kinase beta; rho-Kinase; Coiled-Coil Kinase, rho-Associated; Protein Kinases, ROCK; ROCK I Protein Kinase; ROCK II Protein Kinase; p160 rhoA Binding Kinase ROKalpha; rho Associated Coiled Coil Containing Protein Kinase 1; rho Associated Coiled Coil Containing Protein Kinase 2; rho Associated Coiled Coil Kinase; rho Associated Kinase; rho Associated Kinase 1; rho Associated Kinase 2; rho Associated Kinase alpha; rho Associated Kinase beta; rho Associated Kinases; rho Associated Protein Kinase alpha; rho Associated Protein Kinase beta; rho Kinase; rho-Associated Kinase

Networked: 1279 relevant articles (71 outcomes, 207 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Shimokawa, Hiroaki: 69 articles (10/2015 - 02/2002)
2.	Liao, James K: 31 articles (10/2015 - 07/2002)
3.	Kaibuchi, Kozo: 23 articles (09/2010 - 02/2002)
4.	Fukumoto, Yoshihiro: 19 articles (06/2014 - 01/2004)
5.	Takeshita, Akira: 19 articles (03/2007 - 02/2002)
6.	Li, Tao: 16 articles (05/2015 - 06/2006)
7.	Noma, Kensuke: 14 articles (10/2015 - 05/2003)
8.	Webb, R Clinton: 14 articles (06/2013 - 12/2002)
9.	Liu, Liangming: 13 articles (05/2015 - 06/2005)
10.	Shimokawa, H: 13 articles (10/2007 - 01/2000)

Related Diseases

1.	Pulmonary Hypertension (Ayerza Syndrome) 12/01/2005 - "Inhibition of the type 5 phosphodiesterase and inhibition of Rho kinase are both effective in reducing pulmonary hypertension (PH). " 09/01/2005 - "Rho-kinase inhibitors show promise in pulmonary hypertension." 11/01/2011 - "Our study demonstrates that Rho/Rho-kinase signaling is activated via a Smad-independent pathway in an animal model of pulmonary hypertension with a BMPRII mutation in the cytoplasmic tail domain. " 01/01/2010 - "Studies in the literature suggest that the RhoA/Rho-kinase pathway has an important role in the pathogenesis of pulmonary hypertension." 01/05/2007 - "This study tested whether RhoA/Rho kinase pathway is involved in the pathogenesis of high flow induced pulmonary hypertension in rats. "
2.	Fibrosis (Cirrhosis) 07/01/2011 - "It has been shown that the inhibition of the Rho/Rho kinase (ROCK) pathway prevents tubulointerstitial fibrosis and ameliorates renal function in various progressive renal disorders. " 12/01/2012 - "Targeting of Rho-kinase in hepatic stellate cells not only decreased fibrosis, as previously shown, but also lowers portal pressure acutely without major systemic effects as demonstrated in this study." 11/01/2006 - "Taken together, results from this study suggest that Rho/Rho kinase may not be a necessary or a central pathway for renal fibrosis in the UUO model. " 06/01/2015 - "Rho kinase, oxidative stress, ACE2/Ang 1-7 and lung fibrosis." 05/01/2015 - "Restoration of erectile function by suppression of corporal apoptosis, fibrosis and corporal veno-occlusive dysfunction with rho-kinase inhibitors in a rat model of cavernous nerve injury."
3.	Hypertension (High Blood Pressure) 08/01/2011 - "Antihypertensive and antiremodeling effects of Rho kinase inhibition via activation of ACE2 pathway: support from studies in a human model opposite to hypertension." 06/01/2011 - "A recent study demonstrated that Rho-kinase mediated Ca(2+) sensitization was involved in the pathophysiology of hypertension. " 08/01/2008 - "The goals of our study were to evaluate the haplotype pattern at the Rho-associated kinase 2 (ROCK2) locus and prospectively test the association between the ROCK2 haplotype-tagging single-nucleotide polymorphisms (tagSNPs) with hypertension for verified incident hypertensive patients (n=607) and healthy, normotensive controls (n=586) in a HYPGENE study. " 08/01/2008 - "A major haplotype block at the rho-associated kinase 2 locus is associated with a lower risk of hypertension in a recessive manner: the HYPGENE study." 11/01/2005 - "In the present study, we evaluated the relative contribution of PKC and Rho kinase to myogenic tone in cerebral arteries in hypertension. "
4.	Inflammation 10/01/2010 - "Efferocytosis, the clearance of apoptotic cells, is important in the resolution of inflammation and is regulated by RhoA and rho kinase (ROCK) activation. " 09/01/2006 - "We conclude that Rho-kinase signaling regulates LPS-induced leukocyte adhesion in femoral arteries and veins in vivo and that inhibition of Rho-kinase may be useful in the treatment of pathological inflammation in large blood vessels of the vascular system." 12/01/2012 - "Several studies have demonstrated the importance of Rho-kinase in the modulation of smooth muscle contraction, airway hyperresponsiveness, and inflammation. " 01/01/2011 - "This study investigated the role of Rho kinase signalling in radiation-induced inflammation and intestinal barrier dysfunction. " 01/01/2010 - "Studies have shown that the activation of Rho-kinase is involved in the development of endothelial dysfunction, inflammation, restenosis, and increased vascular tone in a number of cardiovascular disorders. "
5.	Cardiovascular Diseases (Cardiovascular Disease) 05/01/2015 - "Thus, Rho-kinase inhibitors may be useful for the treatment of cardiovascular diseases in humans. " 01/01/2013 - "The aim of this study was to determine whether the activity of Rho-kinase, which has been identified as an important therapeutic target of cardiovascular disease, is enhanced in HF patients. " 01/01/2013 - "Recent advances in basic and clinical studies have identified Rho kinase (ROCK) as an important target potentially implicated in a variety of cardiovascular diseases and ROCK inhibitors were considered as a pharmacological strategy to prevent and treat cardiovascular diseases. " 01/01/2005 - "Rho-kinase represents a new target for the management of cardiovascular diseases and further studies are needed to define the therapeutic potential of Rho-kinase inhibitors." 04/09/2015 - "Rho kinase inhibitors: potentially versatile therapy for the treatment of cardiovascular diseases and more."

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