HOME PRODUCTS SERVICES COMPANY CONTACT FAQ

Chemokine CXCL2

Subscribe to New Research on Chemokine CXCL2

A CXC chemokine that is synthesized by activated MONOCYTES and NEUTROPHILS. It has specificity for CXCR2 RECEPTORS.

Also Known As:

Chemokine (C-X-C Motif) Ligand 2; LDNCF-2; MIP-2 Chemokine; MIP-2alpha; MIP2alpha; Macrophage Inflammatory Protein 2; Macrophage Inflammatory Protein-2alpha; CXCL2, Chemokine; Chemokine, CXCL2; Chemokine, MIP-2; Inflammatory Protein-2alpha, Macrophage; MIP 2 Chemokine; MIP 2alpha; Macrophage Inflammatory Protein 2alpha; CXCL2 Chemokine

Networked: 170 relevant articles (3 outcomes, 9 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Thorlacius, Henrik: 4 articles (12/2011 - 05/2003)
2.	Remick, Daniel G: 3 articles (10/2014 - 12/2002)
3.	Yang, Chen-Hsien: 2 articles (12/2015 - 10/2009)
4.	Huang, Chun-Jen: 2 articles (12/2015 - 10/2009)
5.	Liu, Jie: 2 articles (10/2014 - 10/2006)
6.	Lee, Tzong-Shyuan: 2 articles (04/2014 - 01/2013)
7.	Queen, Jessica: 2 articles (09/2013 - 08/2012)
8.	Li, Wei: 2 articles (01/2013 - 07/2009)
9.	Pirofski, Liise-Anne: 2 articles (04/2012 - 08/2005)
10.	Ayala, Alfred: 2 articles (02/2012 - 08/2005)

Related Diseases

1.	Sepsis (Septicemia) 10/01/2007 - "Several studies have implicated the CXCL2 chemokine as a mediator in the development of sepsis. " 12/01/1999 - "Chemokine (KC and macrophage inflammatory protein 2) profiles also correlated with the severity of sepsis. " 08/07/2005 - "These data suggest that KC and MIP-2alpha differ in their mediation of neutrophil function (apoptosis and chemotaxis) and contribution to the pathogenesis of lung injury following hemorrhage subsequent to sepsis." 10/01/2014 - "In a similar manner, higher concentrations of IL-6, macrophage inflammatory protein 2, IL-10, and IL-1 receptor antagonist were found in cardiac puncture samples compared with other sampling sites 24 h after sepsis induced by cecal ligation and puncture. " 07/01/2009 - "The protective effects were associated with a significant reduction in peritoneal and serum levels of several surrogate markers of sepsis (for example, Interleukin-6 [IL-6], keratinocyte-derived chemokine [KC], monocytes chemoattractant protein-1 [MCP-1], macrophage inflammatory protein-2 [MIP-2], tissue inhibitor of metalloproteinase-1 [TIMP-1], soluble tumor necrosis factor-alpha receptor I [sTNFRI], and soluble tumor necrosis factor-alpha receptor II [sTNFRII]) during a late stage of sepsis. "
2.	Lung Injury 08/07/2005 - "Therefore, we hypothesized that in vivo neutralization of KC or MIP-2alpha during an initial priming insult would produce differential effects on the extent of lung injury by restoring normal neutrophil apoptotic function. " 09/01/2009 - "LPS-induced lung injury and macrophage inflammatory protein 2 release, however, were prevented by CD64 and CD32 blockers (decoy antibodies). " 12/01/2002 - "Keratinocyte growth factor pretreatment is associated with decreased macrophage inflammatory protein-2alpha concentrations and reduced neutrophil recruitment in acid aspiration lung injury." 08/07/2005 - "These data suggest that KC and MIP-2alpha differ in their mediation of neutrophil function (apoptosis and chemotaxis) and contribution to the pathogenesis of lung injury following hemorrhage subsequent to sepsis." 05/01/2012 - "Our results show that lung-specific overexpression of CCL2 protected mice from bleomycin-induced lung injury, characterized by significantly reduced mortality, reduced neutrophil accumulation, and decreased accumulation of the inflammatory mediators IL-6, CXCL2 (macrophage inflammatory protein-2), and CXCL1 (keratinocyte-derived chemokine). "
3.	Ischemia 09/01/2007 - "Total renal concentrations of the chemokine macrophage inflammatory protein 2, which has been shown to bind to DARC and to be crucial in postischemic acute renal failure, were either identical (lipopolysaccharide) or only moderately different (renal ischemia-reperfusion) between wild-type and DARC-/- mice. " 01/01/2007 - "IL-10 treatment improved pulmonary architecture and was associated with a reduction in inflammatory markers, including bronchoalveolar lavage fluid total protein, pulmonary myeloperoxidase activity (a biochemical marker of neutrophils), and the chemokine macrophage inflammatory protein 2. These data demonstrate for the first time that the acute absence of kidney function results in pulmonary injury independent of renal ischemia and highlight the critical role of the kidney in the maintenance of serum cytokine balance and pulmonary homeostasis." 04/01/1999 - "A distinct interleukin-1beta and tumor necrosis factor-alpha cytokine expression was found 0-24 h after hypoxia-ischemia that was accompanied by induction of alpha-chemokines (growth related gene and macrophage inflammatory protein-2). "
4.	Colitis 03/01/2013 - "Monocytes lacking TRPM2 show reduced production of the CXCL2 chemokine, resulting in diminished neutrophilic influx to the colon in chemically induced colitis, and thus protection against tissue ulceration in TRPM2(-/-) mice. " 11/15/2013 - "We hypothesized that keratinocyte chemoattractant (KC)/IL-8 receptor chemokine (C-X-C motif) ligand 2 (CXCL2) mediates DSS-colitis-induced acute kidney injury. "
5.	Inflammation 11/01/2014 - "Consistent with the hypothesis that PAD4 regulates renal tubular inflammation after I/R, mice treated with a PAD4 inhibitor had significantly reduced renal neutrophil chemotactic cytokine (macrophage inflammatory protein-2 and keratinocyte-derived cytokine) expression and had decreased neutrophil infiltration. " 10/01/2013 - "This synergy caused a substantial decrease in lung airspace inflammation and vascular leakage, characterized by significant reductions in protein content, differential neutrophil counts, and proinflammatory cytokine (TNF-α, IL-6, and macrophage inflammatory protein 2) concentrations in bronchoalveolar lavage fluid. " 10/15/2001 - "Macrophage-inflammatory protein 2 (MIP-2) is a major CXC chemokine involved in the migration of polymorphonuclear neutrophils (PMNs) to sites of inflammation. " 08/22/1997 - "Possible participation of macrophage inflammatory protein 2 in neutrophil infiltration in allergic inflammation in rats." 10/01/1995 - "These results suggest that LDNCF-2 (MIP-2) is an important chemotactic factor for neutrophils in the allergic inflammation in rats."

Related Drugs and Biologics

1.	Biological Markers (Surrogate Marker)
2.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
3.	Interleukin-10 (Interleukin 10)
4.	Interleukin-6 (Interleukin 6)
5.	Peroxidase (Myeloperoxidase)
6.	Tissue Inhibitor of Metalloproteinase-1
7.	Tissue Inhibitor of Metalloproteinases (TIMP)
8.	Messenger RNA (mRNA)
9.	Chemokine CXCL2
10.	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)

Related Therapies and Procedures

1.	Resuscitation
2.	Artificial Respiration (Mechanical Ventilation)
3.	Ligation
4.	Cryosurgery
5.	Aftercare (After-Treatment)