Chemokine CCL22

A CC-type chemokine with specificity for CCR4 RECEPTORS. It has activity towards TH2 CELLS and TC2 CELLS.

Also Known As:

CC Chemokine STCP-1; Macrophage-Derived Chemokine; SCYA22 Chemokine; Small Inducible Cytokine A22; Stimulated T Cell Chemotactic Protein 1; CC Chemokine STCP 1; CCL22, Chemokine; Chemokine STCP-1, CC; Chemokine, CCL22; Chemokine, Macrophage-Derived; Chemokine, SCYA22; Macrophage Derived Chemokine; STCP-1, CC Chemokine; CCL22 Chemokine

Networked: 153 relevant articles (3 outcomes, 6 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Nakayama, Takashi: 5 articles (04/2006 - 07/2002)
2.	Yoshie, Osamu: 5 articles (04/2006 - 07/2002)
3.	Lentsch, Alex B: 4 articles (01/2020 - 02/2010)
4.	Pritts, Timothy A: 4 articles (01/2020 - 02/2010)
5.	Mayr, Doris: 4 articles (12/2019 - 11/2011)
6.	Schuster, Rebecca M: 3 articles (01/2020 - 01/2012)
7.	Nakamura, Koichiro: 3 articles (09/2016 - 03/2003)
8.	Anz, David: 3 articles (01/2016 - 11/2011)
9.	Endres, Stefan: 3 articles (01/2016 - 11/2011)
10.	Han, Sang-Chul: 3 articles (03/2013 - 12/2012)

Related Diseases

1.	Atopic Dermatitis (Atopic Eczema) 02/28/2011 - "In particular, the macrophage-derived chemokine CCL22 is directly implicated in Th-2-associated skin inflammatory reactions, and its levels are significantly elevated in serum and are correlated with disease severity in atopic dermatitis. " 11/01/2006 - "Macrophage-derived chemokine (MDC)/CCL22 produced by monocyte derived dendritic cells reflects the disease activity in patients with atopic dermatitis." 08/01/2003 - "Serum concentration of macrophage-derived chemokine may be a useful inflammatory marker for assessing severity of atopic dermatitis in infants and young children." 02/01/2002 - "Serum macrophage-derived chemokine (MDC) levels are closely related with the disease activity of atopic dermatitis." 11/01/2016 - "Here, we hypothesized that Hovenia dulcis branch extract (HDB) and its active constituents ameliorates 2,4-dinitrochlorobenzene-induced atopic dermatitis (AD)-like skin lesions by modulating the T helper Th1/Th2 balance in NC/Nga mice and TNF-α- and IFN-γ-induced production of thymus and activation-regulated chemokine (TARC) and macrophage-derived chemokine (MDC) in HaCaT cells. "
2.	Inflammation (Inflammations) 01/01/2023 - "The expression levels of inflammation-related genes, such as eotaxin, TARC, macrophage-derived chemokine (MDC), and TSLP, in the TLR2 and TLR9 antagonist treatment groups were decreased, compared to those in the ES-P alone or other TLR antagonist treatment groups. " 10/01/2019 - "Immune dysregulation and inflammation have been linked to children with ASD, the latter manifesting in serum levels of macrophage-derived chemokine (MDC) and thymus, and activation-regulated chemokine (TARC). " 01/01/2015 - "Growth modeling of the maternal cytokine milieu throughout normal pregnancy: macrophage-derived chemokine decreases as inflammation/counterregulation increases." 10/15/2008 - "Macrophage-derived chemokine (MDC) CCL22 is a potent chemoattractant for Th2 cells and has been implicated in Th2-predominant allergic inflammation. " 01/01/2003 - "A functional similarity was also found between chronic inflammation and the T-cell zone of lymph nodes (LNs), since a substantial fraction of phenotypically mature DCs in both tissues expressed CCL22 (macrophage-derived chemokine; MDC) and were closely surrounded by memory-type T cells expressing its receptor, CCR4. "
3.	Necrosis 01/01/2017 - "These changes were accompanied by significant decrease in hepatocyte necrosis along with reduction in several serum inflammatory markers such as macrophage derived chemokine, macrophage inflammatory protein-2, KC/GRO, myoglobin and plasminogen activator inhibitor-1. " 03/01/2015 - "In CF-LVAD recipients, serum interleukin-8, tumour necrosis factor-α, and macrophage inflammatory protein-β increased significantly at 9 months, and macrophage-derived chemokine increased at 6 months after CF-LVAD implantation compared with baseline. " 05/01/2016 - "A multivariate profile of seven cytokines (interleukin (IL)-1α, IL-1β, tumour necrosis factor-β, IL-4, fractalkine, macrophage-derived chemokine, and interferon-γ) most accurately predicted the presence of a treatable genital condition, with 77% classification accuracy and 75% cross-validation accuracy (sensitivity 72%; specificity 81%, positive predictive value (PPV) 86%, negative predictive value (NPV) 64%). " 02/15/2015 - "Stimulation with tumour necrosis factor-alpha (TNF-α) and interferon-gamma (IFN-γ) caused a significant increase in the production of the following chemokines: thymus- and activation-regulated chemokine (TARC)/CCL17; macrophage-derived chemokine (MDC)/CCL22; regulated on activation, normal T-cell expressed and secreted (RANTES)/CCL5; and interleukin-8 (IL-8) in HaCaT cells. " 03/01/2019 - "Serum cytokine/chemokines measured included interleukin (IL)-1α, 1β, 3, 4, 5, 6, 8, 13, 15, 17A, 17E(25), 18, 23 and 33, soluble IL-2 receptor alpha, eotaxin-1 (CCL11), -2 (CCL24) and -3 (CCL26), macrophage-derived chemokine (MDC/CCL22), macrophage inflammatory protein (MIP)-1a and -1b, and tumour necrosis factor (TNF)-α. "
4.	Sepsis (Septicemia) 01/01/2015 - "In this study, we investigated the role of CCR4, the CCL17/CCL22 chemokine receptor, in the innate and acquired immune responses during severe sepsis and the role of Tregs in effecting the outcome. " 01/01/2023 - "Additionally, IL-6, IL-10, IL-15, macrophage derived chemokine (MDC), GRO, sCD40 L, granulocyte colony-stimulating factor (G-CSF), and fibroblast growth factor (FGF)-2 levels could be used to provide a significant discrimination between sepsis and nonsepsis patients at day 3 and afterward, with an area under the curve (AUC) of up to 0.90 through a combined analysis of the eight biomarkers (P < 0.001). "
5.	Psoriasis (Pustulosis Palmaris et Plantaris) 01/01/2018 - "Changes in interleukin-17A, macrophage-derived chemokine and adiponectin following treatment of psoriasis with calcipotriol plus betamethasone dipropionate aerosol foam: results from the PSO-ABLE study." 03/01/2001 - "We studied chemokine receptor (CCR1-CCR5, CXCR1-CXCR3), chemokine (interferon-gamma inducible protein 10 [IP-10]), monokine induced by interferon-gamma (MIG), thymus and activation-regulated chemokine (TARC), macrophage-derived chemokine (MDC), and adhesion molecule (cutaneous lymphocyte antigen [CLA], E-selectin, lymphocyte function-associated antigen-1 [LFA-1], intercellular adhesion molecule-1 [ICAM-1], very late antigen 4 [VLA-4], vascular cell adhesion molecule-1 [VCAM-1], alphaEbeta7, and E-cadherin) expression in psoriasis by immunohistology, flow cytometry, and molecular techniques. "

Related Drugs and Biologics

1.	Chemokine CCL17
2.	Macrophage Inflammatory Proteins (Macrophage Inflammatory Protein 1)
3.	Interleukin-6 (Interleukin 6)
4.	Proteins (Proteins, Gene)
5.	Chemokine CCL5
6.	Chemokine CCL2 (Monocyte Chemoattractant Protein 1)
7.	Interleukin-15 (Interleukin 15)
8.	Interleukin-1 Receptors (Interleukin 1 Receptor)
9.	Chemokine CCL4
10.	Interleukin-7 (Interleukin 7)

Related Therapies and Procedures

1.	Resuscitation
2.	Cytoreduction Surgical Procedures
3.	Microspheres (Microsphere)
4.	Immunotherapy
5.	Photothermal Therapy