Pre-B Cell Receptors

Membrane proteins in precursor B-LYMPHOCYTES (pre-B Cells). They are composed of membrane-bound MU IMMUNOGLOBULIN HEAVY CHAINS in complex with SURROGATE LIGHT CHAINS instead of conventional IMMUNOGLOBULIN LIGHT CHAINS. Only successful rearrangement of the VDJ segments, at the Ig heavy chain gene locus (IMMUNOGLOBULIN HEAVY CHAIN GENES), will generate mu heavy chains that can pair with surrogate light chains. Thus formation of the pre-B cell receptors is an important checkpoint in the development of mature B cells.

Also Known As:

Networked: 36 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Müschen, Markus: 10 articles (04/2016 - 03/2004)
2.	Jumaa, Hassan: 4 articles (04/2016 - 06/2005)
3.	Hofmann, Wolf-Karsten: 4 articles (08/2009 - 03/2004)
4.	Geng, Huimin: 3 articles (04/2016 - 08/2013)
5.	Melnick, Ari: 3 articles (04/2016 - 08/2013)
6.	Chen, Zhengshan: 3 articles (03/2015 - 08/2013)
7.	Nahar, Rahul: 3 articles (03/2015 - 08/2009)
8.	Feldhahn, Niklas: 3 articles (09/2005 - 03/2004)
9.	Klein, Florian: 3 articles (09/2005 - 03/2004)
10.	van der Burg, Mirjam: 2 articles (01/2019 - 02/2003)

Related Diseases

1.	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 11/29/2016 - "This Podcast features an interview with Bridget Wilson, author of a Research Article that appears in the 29 November 2016 issue of Science Signaling, about pre-B cell receptor (pre-BCR) signaling in B cell precursor acute lymphoblastic leukemia (BCP-ALL). " 01/01/2016 - "The Expression Pattern of the Pre-B Cell Receptor Components Correlates with Cellular Stage and Clinical Outcome in Acute Lymphoblastic Leukemia." 06/11/2015 - "Rationale for targeting the pre-B-cell receptor signaling pathway in acute lymphoblastic leukemia." 03/09/2015 - "Self-enforcing feedback activation between BCL6 and pre-B cell receptor signaling defines a distinct subtype of acute lymphoblastic leukemia." 01/01/2015 - "Mechanisms of pre-B-cell receptor checkpoint control and its oncogenic subversion in acute lymphoblastic leukemia."
2.	Neoplasms (Cancer) 03/09/2015 - "In this issue of Cancer Cell, Geng and colleagues surveyed the activation status of the pre-B cell receptor and comprehensively investigated downstream signaling mechanisms currently targetable with small molecule inhibitors. " 08/01/2013 - "BACH2 mediates negative selection and p53-dependent tumor suppression at the pre-B cell receptor checkpoint." 08/03/2009 - "These findings provide a rationale for the surprisingly high frequency of IKAROS deletions in Ph(+) ALL and identify IKAROS-mediated cell cycle exit as the endpoint of an emerging pathway of pre-B cell receptor-mediated tumor suppression." 08/03/2009 - "IKAROS also promotes tumor suppression through cooperation with downstream molecules of the pre-B cell receptor signaling pathway, even if expression of the pre-B cell receptor itself is compromised. " 08/03/2009 - "Here, we demonstrate that the pre-B cell receptor functions as a tumor suppressor upstream of IKAROS through induction of cell cycle arrest in Ph(+) ALL cells. "
3.	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma (Leukemia, Pre B Cell) 01/01/2017 - "We use two models of human pre-B-ALL to examine EphA3 function, demonstrating effects on pre-B-cell receptor signaling. " 04/01/2016 - "Loss of PTEN function in pre-B ALL cells was functionally equivalent to acute activation of autoreactive pre-B cell receptor signaling, which engaged a deletional checkpoint for the removal of autoreactive B cells. " 05/01/2015 - "Pre-B-cell Receptor Signaling Is a Therapeutic Target in Pre-B ALL." 03/01/2004 - "Comparing genome-wide gene expression profiles of BCR-ABL1+ pre-B ALL and normal bone marrow pre-B cells by serial analysis of gene expression, many genes involved in pre-B cell receptor signaling are silenced in the leukemia cells. "
4.	Leukemia 11/29/2016 - "Science Signaling Podcast for 29 November 2016: Pre-B cell receptor signaling in leukemia." 03/01/2004 - "We conclude that inhibition of BCR-ABL1 reconstitutes selection for leukemia cells expressing a functional (pre-) B cell receptor." 03/01/2004 - "Comparing genome-wide gene expression profiles of BCR-ABL1+ pre-B ALL and normal bone marrow pre-B cells by serial analysis of gene expression, many genes involved in pre-B cell receptor signaling are silenced in the leukemia cells. " 09/13/2005 - "As shown by overexpression experiments, kinase-deficient splice variants can act as a dominant-negative BTK in that they suppress BTK-dependent differentiation and pre-B cell receptor responsiveness of the leukemia cells. " 12/01/2016 - "To address this, we interrogated activated signaling pathways in a comparative analysis of mouse and human leukemias expressing the fusion protein E2A-PBX1, which is present in 5%-7% of pediatric and 50% of pre-B-cell receptor (preBCR+) acute lymphocytic leukemia (ALL). "
5.	Agammaglobulinemia (Hypogammaglobulinemia) 01/01/2019 - "We found very low numbers of precursor B cells in bone marrow of Good syndrome patients and a differentiation arrest after the pro-B-cell stage; this is different from other agammaglobulinemia patients with a defect in pre B-cell receptor signaling." 12/01/2008 - "Recently two different groups identified mutations in Ig beta, a component of the pre-B cell receptor, responsible for agammaglobulinemia in humans. " 01/01/2016 - "Mutations in the gene encoding for Bruton's-tyrosine-kinase (BTK) and the components of the pre-B-cell receptor complex or downstream signaling molecules have been related to this defect in patients with agammaglobulinemia. "

Related Drugs and Biologics

1.	Phosphotransferases (Kinase)
2.	Oncogene Proteins (Oncogene Protein)
3.	Dasatinib (BMS 354825)
4.	Proteins (Proteins, Gene)
5.	Galectin 1 (LGALS1)
6.	Agammaglobulinaemia Tyrosine Kinase
7.	Catenins
8.	VDJ Recombinases
9.	src-Family Kinases
10.	Extracellular Matrix Proteins

Related Therapies and Procedures

1.	Salvage Therapy