Adiponectin Receptors

Cell surface receptors for ADIPONECTIN, an antidiabetic hormone secreted by ADIPOCYTES. Adiponectin receptors are membrane proteins with multiple cytoplasmic and extracellular regions. They are about 43 kDa and encoded by at least two genes with different affinities for globular and full-length adiponectin.

Also Known As:

Networked: 235 relevant articles (3 outcomes, 48 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Mantzoros, Christos S: 15 articles (08/2012 - 01/2004)
2.	Kadowaki, Takashi: 9 articles (02/2013 - 12/2003)
3.	Yamauchi, Toshimasa: 9 articles (02/2013 - 12/2003)
4.	Tseleni-Balafouta, Sofia: 7 articles (12/2011 - 01/2007)
5.	Mitsiades, Nicholas: 5 articles (12/2011 - 01/2007)
6.	Williams, Catherine J: 5 articles (03/2008 - 06/2006)
7.	Otvos, Laszlo: 4 articles (05/2015 - 01/2011)
8.	Surmacz, Eva: 4 articles (05/2015 - 01/2011)
9.	Buechler, Christa: 4 articles (10/2013 - 06/2006)
10.	Neumeier, Markus: 4 articles (10/2013 - 06/2006)

Related Diseases

1.	Obesity 05/01/2015 - "Possible new therapeutic approach for obesity-related diseases: Role of adiponectin receptor agonists." 04/01/2014 - "Recently, the small molecule adiponectin receptors (AdipoRs) agonist was discovered and suggested that the agonist is a novel therapeutic target for the treatment of type 2 diabetes linked to obesity in an experimental mouse model. " 01/01/2014 - "Obesity: Adiponectin receptor agonists--possible therapeutic approach?" 02/05/2013 - "Adiponectin receptor as a key player in healthy longevity and obesity-related diseases." 02/01/2013 - "No conclusive evidence for association of polymorphisms in the adiponectin receptor 1 gene, AdipoR1, with common obesity."
2.	Colonic Neoplasms (Colon Cancer) 09/01/2008 - "We examined the expression of the adiponectin receptors on normal colon mucosa and colon cancer tissues in a human study using real-time RT-PCR, Western blotting and immunohistochemical staining. " 09/01/2008 - "Adiponectin receptors, AdipoR1/AdipoR2, were expressed in normal colon epithelial and colon cancer cells. " 09/01/2008 - "Expression of adiponectin receptors, AdipoR1 and AdipoR2, in normal colon epithelium and colon cancer tissue." 07/01/2010 - "Furthermore, knockdown of adiponectin receptors such as AdipoR1 and AdipoR2 relieved the suppressive effect of adiponectin on the growth of colon cancer cells. " 09/01/2008 - "These results suggest that adiponectin may exert some effects on normal colon epithelium or colon cancer cells directly through adiponectin receptors. "
3.	Hypertension (High Blood Pressure) 01/01/2015 - "The aim of the study was to find out whether peripheral blood leukocyte adiponectin receptors 1 and 2 (AdipoR1, AdipoR2) protein expression patterns (flow cytometry) differ between the primary hypertension children (n = 57) and healthy controls (n = 19) and if their expression levels are related to selected clinical parameters. " 01/01/2015 - "Expression of Adiponectin Receptors on Peripheral Blood Leukocytes of Hypertensive Children Is Associated with the Severity of Hypertension." 12/28/2011 - "AMP effectively improved hypertension, plasma triglyceride, and HDL-cholesterol, glucose, kidney function parameters, hepatic lipid, enhances plasma nitric oxide, and plasma adiponectin accompanied by the up-regulation of mRNA expression levels of the hepatic adiponectin receptor 2. Single and chronic oral administration of AMP affected the hepatic mRNA expression levels of genes involved in β-oxidation, fatty acid synthesis, and AMP-activated protein kinase. " 02/01/2012 - "Diabetes induced tissue-specific changes in messenger RNAs expression of the following selected genes, which were restored by telmisartan treatment: PPARγ, PPARδ, PPARγ coactivator 1α, adiponectin, adiponectin receptor 1, adiponectin receptor 2, phosphotyrosine binding domain and a pleckstrin homology domain-containing adaptor protein, adenosine monophosphate kinase, and glucose translocator 4. Telmisartan blunted the development of hypertension, insulin resistance, and diabetes in prediabetic Cohen-Rosenthal diabetic hypertensive rats through pleiotropic activity, involving specific gene regulation of target organs."
4.	Body Weight (Weight, Body) 01/01/2004 - "In summary, 1) MTII is an effective treatment for obesity and related metabolic defects in leptin-resistant (DIO, UCP1-DTA) and leptin-sensitive (ob/ob) mouse models of obesity; 2) the effects of MTII on food intake and body weight are more pronounced in DIO mice than in lean mice; 3) the tachyphylactic effect after prolonged MTII administration appears to be, at least in part, caused by a compensatory upregulation of NPY and AgRP mRNA levels, whereas decreasing leptin levels may play a very minor role in mediating tachyphylaxis; and 4) alterations in adiponectin receptor mRNA expression after fasting or MTII treatment may contribute to altered insulin sensitivity and needs to be studied further."
5.	Neoplasms (Cancer) 01/01/2015 - "Studies have come to conflicting conclusions about whether polymorphisms in the adiponectin receptor 1 gene (ADIPOR1) are associated with cancer risk. " 01/01/2014 - "Many studies have indicated possible associations between a polymorphism of adiponectin receptor 1 (ADIPOR1) rs1342387 and risk of cancer, but contradictory results have been reported. " 07/01/2009 - "In a separate study, we also studied for the first time whether adiponectin receptors 1 and 2 are expressed in PC by studying 16 PC tumor tissue samples which were analyzed using immunohistochemistry. " 08/01/2015 - "Two types of adiponectin receptor, AdipoR1 and AdipoR2, have been detected in various cancer tissues such as CRC. " 07/01/2015 - "Adiponectin receptor 1 expression in tumor tissues with the AA genotype was significantly lower than that for other genotypes (mean rank: AA 18.55, AG 25, GG 45.76, p = 0.001). "

Related Drugs and Biologics

1.	Adiponectin
2.	Messenger RNA (mRNA)
3.	Leptin
4.	Insulin (Novolin)
5.	Glucose (Dextrose)
6.	AMP-Activated Protein Kinases
7.	Adenosine Monophosphate (AMP)
8.	Nitric Oxide (Nitrogen Monoxide)
9.	HDL Cholesterol
10.	Leptin Receptors

Related Therapies and Procedures

1.	Oral Administration
2.	Highly Active Antiretroviral Therapy (HAART)
3.	Chemoprevention
4.	Caloric Restriction
5.	Electroacupuncture