Chemokine CCL20

A CC-type chemokine with specificity for CCR6 RECEPTORS. It has activity towards DENDRITIC CELLS; T-LYMPHOCYTES; and B-LYMPHOCYTES.

Also Known As:

Exodus-1 Chemokine; MIP-3-alpha; Macrophage Inflammatory Protein 3 alpha; SCYA20 Chemokine; Small Inducible Cytokine A20; CCL20, Chemokine; Chemokine, CCL20; Chemokine, Exodus-1; Chemokine, SCYA20; Exodus 1 Chemokine; CCL20 Chemokine

Networked: 60 relevant articles (1 outcomes, 7 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Marsigliante, Santo: 2 articles (11/2017 - 09/2013)
2.	Muscella, Antonella: 2 articles (11/2017 - 09/2013)
3.	Vetrugno, Carla: 2 articles (11/2017 - 09/2013)
4.	Hsu, Ping-Ning: 2 articles (02/2017 - 07/2010)
5.	Tsai, Hwei-Fang: 2 articles (02/2017 - 07/2010)
6.	Gold, Jason S: 2 articles (08/2016 - 01/2014)
7.	Munshi, Nikhil C: 2 articles (08/2016 - 01/2014)
8.	Nandi, Bisweswar: 2 articles (08/2016 - 01/2014)
9.	Pai, Christine: 2 articles (08/2016 - 01/2014)
10.	Prabhala, Rao H: 2 articles (08/2016 - 01/2014)

Related Diseases

1.	Foot-and-Mouth Disease 01/01/2018 - "This study aimed to investigate the chemokine CCL20, a macrophage inflammatory protein-3 alpha, for adjuvant potential in inactivated foot-and-mouth disease (FMD) vaccine. " 01/01/2018 - "Chemokine CCL20 plasmid improves protective efficacy of the Montanide ISA™ 206 adjuvanted foot-and-mouth disease vaccine in mice model."
2.	Neoplasms (Cancer) 05/01/2023 - "In this study, we investigated how radiation modulates Treg infiltration in tumors through the chemokine CCL20. " 01/01/2022 - "CircSMARCC1 up-regulates the chemokine CCL20 secretion by sponging miR-1322, which is involved in the crosstalk between tumor cells and TAMs by targeting CCL20/CCR6 signaling to promote progression of PCa." 01/01/2018 - "This may be partly mediated by regulating tumor cell production of the chemokine CCL20." 07/10/2015 - "We found that a chemokine CCL20 was significantly up-regulated by NNK, and in 78/173 (45.1%) patients the expression of CCL20 was higher in tumor samples than their adjacent normal lung tissues. " 09/01/2013 - "CCR6/CCL20 chemokine expression profile in distinct colorectal malignancies."
3.	Inflammation (Inflammations) 01/01/2014 - "pylori infection induces the production of inflammatory chemokine CCL20 in gastric mucosa and leads to gastric inflammation. " 01/01/2021 - "In this study, we present a detailed structure-function study of an anti-CCL20 humanized IgG1 mAb that neutralizes CCL20 chemokine and prevents the recruitment of Th17 cells to sites of inflammation. " 05/01/2021 - "IL-17A produced by T cells potently upregulates the production of chemokine CCL20 in the keratinocytes, which further chemoattracts IL-17A-producing CCR6+ immune cells to the site of inflammation. " 01/01/2020 - "Control mice simply receiving EtOH displayed minimal cutaneous inflammation, characterized by epidermal infiltrates of T lymphocytes and the overexpression of IL-17A and the Th17-recruiting chemokine CCL20. " 04/01/2014 - "Lack of flagella correlated with a reduced ability of triggering interleukin-8 (IL-8) and CCL20 chemokine expression in human intestinal Caco-2 cells and with reduced early inflammation in the ceca of streptomycin-pretreated C57/BL6 mice. "
4.	Infections 01/01/2014 - "pylori infection induces the production of inflammatory chemokine CCL20 in gastric mucosa and leads to gastric inflammation. " 02/01/2017 - "pylori infection, significant increases in CCR6+ CD3+ T cell infiltration in the gastric mucosa was observed, and the CCR6 ligand, CCL20 chemokine, was selectively expressed in inflamed gastric tissues. " 11/01/2013 - "Here we demonstrate that activation of Toll-like receptor 1 (TLR1) in the epithelium leads to the upregulation of the chemokine CCL20 during oral infection with Yersinia enterocolitica. " 07/01/2010 - "pylori infection, there was significantly increased CCR6(+)CD3(+ )T-cell infiltration in the gastric mucosa, and the CCR6 ligand, CCL20 chemokine, was selectively expressed in inflamed gastric tissues. " 10/08/2009 - "Human intestinal epithelial cells (IECs) secrete the chemokine CCL20 in response to infection by various enteropathogenic bacteria or exposure to bacterial flagellin. "
5.	Carcinogenesis 01/01/2014 - "CCR6, the sole receptor for the chemokine CCL20, promotes spontaneous intestinal tumorigenesis." 12/01/2012 - "Recent studies have demonstrated that the chemokine CCL20 and its receptor CCR6 may be involved in tumorigenesis, tumor progression and metastatic spread of various human malignancies. " 11/01/2017 - "Recently, we showed a role of CCL20 chemokine in proning the healthy tissue neighboring the tumor to carcinogenesis. " 01/01/2014 - "Interactions between the inflammatory chemokine CCL20 and its receptor CCR6 have been associated with colorectal cancer growth and metastasis, however, a causal role for CCL20 signaling through CCR6 in promoting intestinal carcinogenesis has not been demonstrated in vivo. "

Related Drugs and Biologics

1.	Vaccines
2.	Monatide (IMS 3015)
3.	Chemotactic Factors
4.	CASP8 and FADD-Like Apoptosis Regulating Protein (FLIP-S)
5.	Dextran Sulfate
6.	Immunoglobulin G (IgG)
7.	Ligands
8.	Interleukin-17 (Interleukin 17)
9.	Chemokines
10.	Cytokines

Related Therapies and Procedures

1.	Ligation
2.	Therapeutics
3.	Drug Therapy (Chemotherapy)