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Chemokine CCL11

A CC-type chemokine that is specific for CCR3 RECEPTORS. It is a potent chemoattractant for EOSINOPHILS.
Also Known As:
Chemokine (C-C Motif) Ligand 11; Eotaxin-1; Small Chemokine (C-C Motif) Ligand 11; CCL11, Chemokine; Chemokine, CCL11; Eotaxin 1; CCL11 Chemokine
Networked: 216 relevant articles (9 outcomes, 26 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Rothenberg, Marc E: 12 articles (03/2016 - 11/2003)
2. Mishra, Anil: 4 articles (01/2019 - 11/2003)
3. Broide, David H: 4 articles (01/2014 - 04/2007)
4. Cho, Jae Youn: 4 articles (01/2014 - 04/2007)
5. Hogan, Simon P: 4 articles (05/2013 - 07/2004)
6. Foster, Paul S: 3 articles (01/2020 - 07/2004)
7. Yang, Ming: 3 articles (01/2020 - 07/2004)
8. Fujikura, Yoshihisa: 3 articles (07/2019 - 01/2014)
9. Ogino, Keiki: 3 articles (07/2019 - 01/2014)
10. Takemoto, Kei: 3 articles (07/2019 - 01/2014)

Related Diseases

1. Inflammation (Inflammations)
2. Asthma (Bronchial Asthma)
10/01/2007 - "This study finding provide a strong evidence that Eotaxin 1 Thr23Thr homozygote has a protective effect on asthma and significantly decreases plasma Eotaxin 1 concentrations in asthmatics in Taiwan."
01/01/2021 - "Our results suggest that short telomeres and up-regulated eotaxin-1, features of accelerated aging, could prematurely contribute to a senescent phenotype increasing the risk for early development of age-related diseases in asthma."
02/01/2019 - "An increase of CD11b+ Siglec+eosinophils was observed in these mice while in vitro, no significant polarization of BMDM was found when treated with PM2.5. Together, our findings suggested that PM2.5 could exacerbate asthma by aggravating M2-polarization, highlighting for the first time that Eotaxin-1 released from M2 macrophages plays a crucial role in asthma pathogenesis."
01/01/2014 - "Our data demonstrate that: 1) Asthmatic HBEC exhibit an exaggerated apical, but not basal, secretion of TSLP after dsRNA exposure; 2) TSLP exposure induces unidirectional (apical) secretion of CCL11/eotaxin-1 in asthmatic HBEC and enhanced CCL11/eotaxin-1 secretion in asthmatic HASMC; 3) Rhinovirus-induced asthma exacerbations in children are associated with in vivo airway secretion of TSLP and CCL11/eotaxin-1. There are virally-induced TSLP-driven secretory immune responses at both sides of the bronchial epithelial barrier characterized by enhanced CCL11/eotaxin-1 secretion in asthmatic airways. "
01/01/2014 - "A significant association was found between asthma and current betel chewing (adjusted odds ratio 2.05, 95% CI = 1.12-3.76), which was independent of potential confounders but was attenuated following adjustment for eotaxin-1. "
3. Neoplasms (Cancer)
4. Atopic Dermatitis (Atopic Eczema)
5. Eosinophilia

Related Drugs and Biologics

1. Chemokines
2. Chemokine CCL24
3. Interleukin-5 (Interleukin 5)
4. Cytokines
5. Proteins (Proteins, Gene)
6. Vascular Cell Adhesion Molecule-1 (Vascular Cell Adhesion Molecule 1)
7. Budesonide (Pulmicort)
8. Cyclosporine (Ciclosporin)
9. Tacrolimus (Prograf)
10. Transglutaminases

Related Therapies and Procedures

1. Injections
2. Immunotherapy
3. Intranasal Administration
4. Robotic Surgical Procedures
5. Therapeutics