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B-Cell Prolymphocytic Leukemia

Subscribe to New Research on B-Cell Prolymphocytic Leukemia

A neoplasm of prolymphocytes affecting the blood, bone marrow, and spleen. It is characterized by prolymphocytes exceeding 55% of the lymphoid cells in the blood and profound splenomegaly.

Also Known As:

Leukemia, Prolymphocytic, B-Cell; B Cell Prolymphocytic Leukemia; B-Cell Prolymphocytic Leukemias; Leukemia, B-Cell Prolymphocytic; Leukemias, B-Cell Prolymphocytic; Prolymphocytic Leukemia, B-Cell; Prolymphocytic Leukemias, B-Cell

Networked: 26 relevant articles (3 outcomes, 1 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia)
2.	Hairy Cell Leukemia
3.	Lymphoma (Lymphomas)
4.	Lymphoproliferative Disorders (Lymphoproliferative Disorder)
5.	Neoplasms (Cancer)

Experts

1.	Ishikawa, Takayuki: 1 article (04/2014)
2.	Hashimoto, Hisako: 1 article (04/2014)
3.	Tabata, Sumie: 1 article (04/2014)
4.	Matsushita, Akiko: 1 article (04/2014)
5.	Arima, Hiroshi: 1 article (04/2014)
6.	Ono, Yuichiro: 1 article (04/2014)
7.	Takahashi, Takayuki: 1 article (04/2014)
8.	Ohno, Hitoshi: 1 article (01/2014)
9.	Iioka, Futoshi: 1 article (01/2014)
10.	Hayashida, Masahiko: 1 article (01/2014)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to B-Cell Prolymphocytic Leukemia:

1.	rituximab (Mabthera)FDA Link 05/01/2004 - "We report a patient with B-cell prolymphocytic leukemia (PLL) who was treated successfully with the monoclonal anti-CD20 antibody (rituximab). " 01/01/2002 - "We analyzed the correlation between CD20-expression level and efficacy of rituximab treatment in eight patients with refractory or relapsed B-CLL and two patients with B-cell prolymphocytic leukemia (B-PLL). " 01/01/2002 - "Level of CD 20-expression and efficacy of rituximab treatment in patients with resistant or relapsing B-cell prolymphocytic leukemia and B-cell chronic lymphocytic leukemia." 03/01/1999 - "These data also suggest that rituximab may have activity in a variety of other lymphoid neoplasms, such as chronic lymphocytic leukemia and B-cell prolymphocytic leukemia." 08/01/2010 - "[Successful treatment of B-cell prolymphocytic leukemia (B-PLL) with FCR-Lite (fludarabine, cyclophosphamide, rituximab) protocol]."
2.	CD18 AntigensIBA 03/01/2000 - "This study analyzed the expression of the beta2 integrin CD11c in 155 patients with well-characterized B-cell chronic lymphoproliferative disorders: 106 B-cell chronic lymphocytic leukemias (B-CLL), 21 hairy cell leukemias (HCL), 9 B-cell prolymphocytic leukemias (PLL) and 19 low grade non-Hodgkin's lymphomas (NHL) in leukemic phase. "
3.	Cladribine FDA LinkGeneric 01/01/1997 - "Major activity of cladribine in patients with de novo B-cell prolymphocytic leukemia." 11/01/1992 - "Rapid response of B-cell prolymphocytic leukemia to 2-chlorodeoxyadenosine."
4.	AntigensIBA 09/15/1995 - "B-cell prolymphocytic leukemia expressing discordant myeloid-associated antigens in simultaneous specimens from bone marrow and peripheral blood." 01/01/2005 - "Other chronic B cell malignancies including hairy cell leukemia (HCL) and B cell prolymphocytic leukemia (B-PLL) are CD5 negative or express this antigen in a weak way. "
5.	fludarabineIBA 05/01/2005 - "Although B-cell prolymphocytic leukemia is also a progressive disease, some patients can achieve a prolonged progression-free-survival with fludarabine. " 08/01/2010 - "[Successful treatment of B-cell prolymphocytic leukemia (B-PLL) with FCR-Lite (fludarabine, cyclophosphamide, rituximab) protocol]."
6.	CD5 AntigensIBA 01/01/2010 - "We report a 68-year-old woman with B-cell prolymphocytic leukemia (B-PLL) expressing CD5 antigen. "
7.	CD13 Antigens (Alanine Aminopeptidase)IBA 08/01/1994 - "We report a 74-year-old female with B-cell prolymphocytic leukemia (B-PLL) expressing CD13 antigen. " 08/01/1994 - "B-cell prolymphocytic leukemia expressing CD13 antigen."
8.	Interferon-alpha (Interferon Alfa)FDA Link 11/01/1993 - "She was diagnosed as having B-cell prolymphocytic leukemia, and treated with alpha-interferon and VP therapy with progression. "
9.	CyclinsIBA 08/01/2011 - "Pitfalls in the differential diagnosis versus B-cell chronic lymphocytic leukemia, B-cell prolymphocytic leukemia, cyclin D1-positive diffuse large B-cell lymphoma, hairy cell leukemia, and plasma cell tumors will be discussed, including the usefulness new diagnostic markers SOX11 and CD200. "
10.	Pentostatin (Nipent)FDA LinkGeneric 07/25/2013 - "Smudge cells following treatment with pentostatin in a patient with B-cell prolymphocytic leukemia."

Therapies and Procedures

1.	Hematopoietic Stem Cell Transplantation 04/01/2014 - "Successful allogeneic hematopoietic stem cell transplantation with reduced-intensity conditioning for B-cell prolymphocytic leukemia in partial remission."
2.	Splenectomy 11/01/2012 - "In the other 2 patients, a B-cell prolymphocytic leukemia-like picture prompted splenectomy. " 11/01/2012 - "In 2 patients, splenectomy preceded a B-cell prolymphocytic leukemia-like picture, and the spleen showed splenic marginal zone lymphoma or splenic diffuse red pulp small B-cell lymphoma with increased (10%-20%) nucleolated cells consistent with prolymphocytes. " 07/01/1993 - "Between February, 1970 and September, 1991, we performed splenectomies on 70 patients with chronic lymphoproliferative disorders including primary leukemias: 19 B-cell chronic lymphocytic leukemia, 1 B-cell prolymphocytic leukemia, 22 hairy cell leukemias, 4 large granular lymphocytic leukemias, 1 T-cell prolymphocytic leukemia, and non-Hodgkin's lymphomas (NHL): 10 splenic lymphomas with villous lymphocytes, 4 follicular lymphomas, 5 mantle cell lymphomas, 3 lymphoplasmacytic and 1 large cell NHL. "
3.	Peripheral Blood Stem Cell Transplantation (Peripheral Stem Cell Transplantation) 06/01/2005 - "Allogeneic peripheral stem-cell transplantation with reduced-intensity conditioning regimen in refractory primary B-cell prolymphocytic leukemia: a long-term follow-up."
4.	Bone Marrow Transplantation (Transplantation, Bone Marrow) 03/01/1996 - "One patient with refractory B cell chronic lymphocytic leukemia (CLL) and another with refractory B cell prolymphocytic leukemia (PLL) underwent bone marrow transplantation (BMT) from HLA-identical siblings. "
5.	Drug Therapy (Chemotherapy) 04/01/2014 - "B-cell prolymphocytic leukemia (B-PLL) is a rare, chemotherapy-resistant lymphoid neoplasm. "