Adipokines

Polypeptides produced by the ADIPOCYTES. They include LEPTIN; ADIPONECTIN; RESISTIN; and many cytokines of the immune system, such as TUMOR NECROSIS FACTOR-ALPHA; INTERLEUKIN-6; and COMPLEMENT FACTOR D (also known as ADIPSIN). They have potent autocrine, paracrine, and endocrine functions.

Also Known As:

Networked: 3979 relevant articles (86 outcomes, 584 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Blüher, Matthias: 38 articles (07/2015 - 07/2006)
2.	Fasshauer, Mathias: 36 articles (10/2015 - 04/2004)
3.	Stumvoll, Michael: 34 articles (10/2015 - 11/2004)
4.	Aller, R: 29 articles (11/2015 - 01/2007)
5.	Izaola, O: 28 articles (11/2015 - 01/2007)
6.	Xu, Aimin: 28 articles (08/2015 - 06/2005)
7.	de Luis, D A: 23 articles (11/2015 - 01/2007)
8.	Gualillo, Oreste: 23 articles (01/2015 - 06/2007)
9.	Conde, R: 23 articles (10/2013 - 01/2007)
10.	Scherer, Philipp E: 22 articles (09/2015 - 09/2003)

Related Diseases

1.	Insulin Resistance 07/01/2013 - "Berberis aristata/Silybum marianum fixed combination seems to be safe and effective in improving lipid profile, but also in improving insulin resistance and adipocytokines levels. " 10/01/2013 - "According to these results HAMS is associated with insulin resistance and imbalance of adipokines serum concentration, therefore identification of pathways related to HAMS development might be helpful in management of the syndrome. " 07/01/2009 - "Practising physical activity and following a balanced diet, similar to the Mediterranean pattern with low fat and salt consumption, would be helpful for improving insulin resistance and adipokines levels in obese people, thus helping improving their health status in the long run." 11/01/2006 - "Furthermore, it improved endothelial function, oxidative stress, and adipokine release in obese type 2 diabetic patients with insulin resistance." 09/01/2015 - "The aim of our study was to examine the changes in weight, adipocytokines levels and insulin resistance after a high-protein/low carbohydrate hypocaloric diet vs. a standard hypocaloric diet during an intervention of 9 months. "
2.	Obesity 06/01/2003 - "Greater understanding of adipokine regulation, however, should result in the design of improved treatment strategies to control disease states associated with increase adiposity, an important outcome in view of the growing worldwide epidemic of obesity." 12/01/2007 - "The description of the product of the gene obese (ob) demonstrated the role of adipose tissue in the physiopathology of obesity-related diseases, and helped to increase the identification of numerous other adipokines, many of a pro-inflammatory nature. " 10/01/2006 - "The efficacy of adipokines and indices of metabolic syndrome as predictors of severe obesity-related hepatic steatosis." 01/01/2016 - "The aim of the present study was to verify whether selected functional single nucleotide polymorphisms in LEP, LEPR, and ADIPOQ loci are associated with the development of obesity and serum levels of the respective adipokines in prepubertal white children with obesity. " 04/01/2015 - "The purpose of this study was firstly to evaluate the adipokines and biochemical changes in obese subjects in relation to different grades of obesity and in relation to gender difference (males versus females) and secondly to evaluate the role of TNF-α in obesity. "
3.	Inflammation 02/01/2011 - "In this study, Malbec RW, but not alcohol alone, improved the balance of adipocytokines and attenuated the oxidative stress and vascular inflammation in a model of MS, suggesting that nonalcohol components of RW are responsible for the beneficial effects." 06/01/2007 - "Targeting of individual adipokines or their upstream regulation may prove effective in preventing acute and chronic inflammation-related metabolic complications." 11/01/2014 - "The aim of this study was to investigate the relationship between markers of adiposity, inflammation and adipokines in a Portuguese obese pediatric population. " 09/12/2014 - "The present study shows the proof of principle that the novel adipokine CTRP-3 is a potent inhibitor of LPS-induced systemic inflammation and LPS-induced signaling in adipose tissue in vivo." 09/01/2014 - "The suitability of the OR/OP-CD rat model as a research tool to study inflammation, oxidative stress, and adipokine production requires further investigation."
4.	Weight Loss (Weight Reduction) 01/01/2011 - "Although there is evidence of improvement in circulating levels of adipokines with weight loss, few studies relate such changes to specific diets. " 01/01/2015 - "Even in those with minimal weight loss ALT levels, steatosis, adipokines and cardiovascular risk factors improved." 01/01/2015 - "The aim of our study was to investigate the influence of Thr54 polymorphism on metabolic response, weight loss and serum adipokine levels secondary to high-protein/low-carbohydrate vs. standard hypocaloric diets during 9 months. " 04/01/2014 - "The study objective was to examine the hypothesis that adipokine changes during intentional weight loss may be associated with changes in QOL. " 01/01/2014 - "Several studies have identified relationships between weight loss and adipokine levels; however, none have looked at the combined effect of aerobic exercise training with the consumption of a low- or a high-glycemic diet. "
5.	Atherosclerosis 01/01/2015 - "Although recent animal studies have suggested that angiopoietin-like protein 2 (ANGPTL2), a novel inflammatory adipokine, is likely to be involved in the pathogenesis of atherosclerosis, in rodents, little is known regarding whether serum ANGPTL2 level is also associated with atherosclerosis in humans, especially in patients with type 2 diabetes. " 06/01/2012 - "Adipokines and body fat composition in South Asians: results of the Metabolic Syndrome and Atherosclerosis in South Asians Living in America (MASALA) study." 01/01/2012 - "Our study focused on the ability of epicardial adipocytes to produce bioactive substances and compare the extent of this production with the production of adipokines in visceral adipocytes, which are well known endocrine cells capable of contributing to the development of atherosclerosis. " 09/01/2011 - "Our study supports the hypothesis that decreased level of adipokine(s), together with increased oxidative stress, pro-inflammatory marker(s) as well as endothelial adhesion molecule(s) contributes to the complex process of atherosclerosis in type 2 diabetic obese patients that may lead eventually to CHD." 12/01/2015 - "Apelin is an adipokine that has a critical role in the development of atherosclerosis, which may offer potential for therapy. "

Related Drugs and Biologics

1.	Insulin (Novolin)
2.	Adiponectin
3.	Leptin
4.	Glucose (Dextrose)
5.	Cytokines
6.	Resistin
7.	Blood Glucose (Blood Sugar)
8.	Interleukin-6 (Interleukin 6)
9.	Biological Markers (Surrogate Marker)
10.	Lipids

Related Therapies and Procedures

1.	Bariatric Surgery
2.	Caloric Restriction
3.	Gastric Bypass (Roux-en-Y Gastric Bypass)
4.	Continuous Ambulatory Peritoneal Dialysis (CAPD)
5.	Fat-Restricted Diet (Diet, Fat Restricted)