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Chemokine CXCL12

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A CXC chemokine that is chemotactic for T-LYMPHOCYTES and MONOCYTES. It has specificity for CXCR4 RECEPTORS. Two isoforms of CXCL12 are produced by alternative mRNA splicing.

Also Known As:

Pre-B-Cell Growth-Stimulating Factor; SDF-1alpha; SDF-1beta; SDF1-3'A; Stromal Cell-Derived Factor 1; Stromal Cell-Derived Factor-1alpha; CXCL12, Chemokine; Cell-Derived Factor-1beta, Stromal; Chemokine, CXCL12; Growth-Stimulating Factor, Pre-B-Cell; Pre B Cell Growth Stimulating Factor; SDF 1alpha; SDF 1beta; SDF1 3'A; Stromal Cell Derived Factor 1; Stromal Cell Derived Factor 1alpha; Stromal Cell Derived Factor 1beta; CXCL12 Chemokine; Stromal Cell-Derived Factor-1beta

Networked: 675 relevant articles (14 outcomes, 88 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Luker, Gary D: 8 articles (02/2015 - 10/2009)
2.	Schettini, Gennaro: 8 articles (08/2008 - 11/2002)
3.	Bajetto, Adriana: 8 articles (08/2008 - 11/2002)
4.	Luker, Kathryn E: 7 articles (01/2014 - 10/2009)
5.	Weber, Christian: 7 articles (07/2010 - 11/2003)
6.	Florio, Tullio: 7 articles (08/2008 - 11/2002)
7.	Porcile, Carola: 7 articles (08/2008 - 04/2003)
8.	Fujii, Nobutaka: 6 articles (01/2012 - 11/2003)
9.	Spaziante, Renato: 6 articles (08/2008 - 11/2002)
10.	Hattermann, Kirsten: 5 articles (07/2014 - 04/2010)

Related Diseases

1.	Infection 05/01/2010 - "The protective CCR5-Delta32 mutation is absent in the Zhuang population, but CCR2-64I and SDF1-3'A are relatively common and seem not to confer protection against HIV-1 infection. " 12/01/2005 - "Among EA, rs754618 was associated with an increased risk of infection (OR=1.50, P=0.03), while rs1801157 (=SDF1-3'A) was associated with protection against infection (OR=0.63, P=0.01). " 10/01/1999 - "SDF1-3'A homozygotes also showed possible protection against HIV-1 infection. " 01/01/2011 - "In this study, we show that acute Plasmodium chabaudi AS infection in C57Bl/6 mice causes severe disruption of B lymphopoiesis in the bone marrow, affecting in particular pro-, pre-, and immature B cells as well as the expression of the bone marrow B-cell retention chemokine CXCL12. " 06/01/2009 - "[A transcriptional study of SDF-1alpha expression in PBL and the correlation between SDF-1alpha transcription and HIV-1 infection]."
2.	Disease Progression 10/01/2006 - "The results observed in this study support the hypothesis that the mutation of SDF1-3'A could have a possible late-stage protective effect on HIV-1 disease progression in the Brazilian population." 03/01/2006 - "To investigate variant genotyping of CCR2-64I, SDF1-3'A and CCR5Delta32 in HIV-1 infected Chinese Long-term nonprogressors and to study their association with disease progression. " 06/01/2009 - "It would be worthwhile to determine the mechnism of HIV affecting on SDF-1alpha genes transcription and the up-regulated SDF-1alpha expression on the disease progression." 06/01/2009 - "The result demonstrated an association between SDF-1alpha transcription and disease progression. " 10/01/2006 - "The effect of stromal cell-derived factor 1 (SDF1/CXCL12) genetic polymorphism on HIV-1 disease progression."
3.	Cicatrix (Scar) 04/29/2008 - "Consistent with improved cardiac function, mice exposed to SDF-1alpha demonstrated significantly decreased scar formation than control mice. " 11/01/2013 - "Stromal cell-derived factor 1 (SDF-1) and its interaction with chemokine receptor 4 (CXCR4) have been noted for participating in the wound healing process, and may paradoxically develop hypertrophic scarring. " 11/01/2007 - "In 1-week post-MI rats, intense SDF-1 immunoreactivity was detected in scar-residing vessels, and SDF-1alpha messenger ribonucleic acid (mRNA) levels were significantly greater in the infarct region compared to the noninfarcted left ventricle (NILV). " 11/01/2007 - "Collectively, these data support the existence of an SDF-1alpha gradient in the damaged rat myocardium increasing toward the infarct region and highlight the novel observation that AMD3100 antagonism of the SDF-1alpha/CXCR4 axis reduced scar expansion and improved contractility. "
4.	Acquired Immunodeficiency Syndrome (AIDS) 03/01/2010 - "Due to the great genetic diversity among Brazilian population and the lack of studies on SDF1-3'A allele, our study of this allelic frequency in these different Brazilian ethnic groups could be important to identification of biomarker for therapeutic support in progression to AIDS and a molecular marker for analysis of evolutionary relationships among human populations." 08/01/2000 - "To study the frequency and polymorphism of three mutations (CCR5(Delta)32, CCR2-64I and SDF1-3'A alleles) conferring resistance to determined HIV-1/AIDS in the indigenous Han population in China. " 06/01/2011 - "SDF1-3'A was also associated with decreased risk for AIDS, but its effect was only evident when CCR2-64I was present as well. " 01/01/2010 - "Stromal cell-derived factor 1 polymorphism in patients infected with HIV and implications for AIDS progression in Tunisia." 07/01/2008 - "SDF1-3'A reduced viral suppression (OR=0.61; P=0.02) and accelerated AIDS (RH=3.18; P=0.009). "
5.	Wounds and Injuries (Trauma) 08/01/2010 - "During the 14-day study period, serial ultrasonography showed a 20-fold increase in omental thickness, and enzyme-linked immunosorbent assay revealed a 4-fold increase in SDF-1alpha concentration in local wound fluid. " 08/01/2010 - "We hypothesized that by increasing the level of the chemokine CXCL12 in wounds of diabetic mice, we would increase stem cell recruitment to the wound and, thus, accelerate time to wound closure. " 08/01/2010 - "Serial stromal cell-derived factor 1alpha (SDF-1alpha) concentrations were measured in blood, wound, and peritoneal fluids by enzyme-linked immunosorbent assay. " 06/01/2010 - "We also found that one mechanism by which SDF-1alpha enhances wound closure likely involves increased skin vascularization. " 06/01/2010 - "Specific knockdown of SDF-1alpha expression led to drastically reduced efficiency of MSCs in improving wound closure, indicating that SDF-1alpha secretion by MSCs is largely responsible for their beneficial action. "

Related Drugs and Biologics

1.	Chemokine CXCL12
2.	JM 3100
3.	CXCR4 Receptors (CXCR4 Receptor)
4.	Messenger RNA (mRNA)
5.	Chemokine Receptors
6.	Chemokine CCL2 (Monocyte Chemoattractant Protein 1)
7.	Phosphotransferases (Kinase)
8.	Ligands
9.	3' Untranslated Regions (3' UTR)
10.	Proteins (Proteins, Gene)

Related Therapies and Procedures

1.	Intra-Articular Injections
2.	Injections
3.	Electroacupuncture
4.	Tourniquets
5.	Transplantation (Transplant Recipients)