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Agouti-Related Protein

A secreted protein of approximately 131 amino acids that is related to AGOUTI SIGNALING PROTEIN and is also an antagonist of MELANOCORTIN RECEPTOR activity. It is expressed primarily in the HYPOTHALAMUS and the ADRENAL GLAND. As a paracrine signaling molecule, AGRP is known to regulate food intake and body weight. Elevated AGRP has been associated with OBESITY.
Also Known As:
AGRP Protein; AGRT Protein; Agouti Related Protein
Networked: 206 relevant articles (2 outcomes, 18 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Wu, Qi: 7 articles (01/2020 - 02/2008)
2. Palmiter, Richard D: 6 articles (09/2013 - 10/2005)
3. Wardlaw, Sharon L: 4 articles (11/2019 - 10/2014)
4. Diéguez, Carlos: 4 articles (06/2012 - 08/2010)
5. López, Miguel: 4 articles (06/2012 - 08/2010)
6. Nogueiras, Rubén: 4 articles (06/2012 - 08/2010)
7. Cone, Roger D: 3 articles (01/2021 - 01/2004)
8. Bruce, Jeffrey N: 3 articles (11/2019 - 10/2014)
9. Page-Wilson, Gabrielle: 3 articles (01/2019 - 10/2014)
10. Lowell, Bradford B: 3 articles (01/2017 - 04/2011)

Related Diseases

1. Body Weight (Weight, Body)
2. Insulin Resistance
3. Weight Loss (Weight Reduction)
01/01/2019 - "GH activates agouti-related protein (AgRP) neurons and GH receptor (GHR) ablation in AgRP cells mitigates highly characteristic hypothalamic and metabolic adaptations induced by weight loss. "
04/01/2016 - "The effect of EA on weight loss may be related to improved insulin resistance caused by changes in the adipocyte size and by reductions in the expressions of neuroprotein Y/agouti-related protein and protein tyrosine phosphatase 1B. "
03/01/2007 - "To characterize the association of weight loss with central and peripheral appetite regulation, the signaling protein agouti-related protein (AGRP), the orexigenic hormone ghrelin, and its recently identified antagonist obestatin were determined. "
01/01/2006 - "Hypophysiotropic TRH neurons are located in the medial and periventricular parvocellular subdivisions of the PVN and receive direct monosynaptic projections from two, separate, populations of leptin-responsive neurons in the hypothalamic arcuate nucleus containing either alpha-melanocyte-stimulating hormone (alpha-MSH) and cocaine- and amphetamine-regulated transcript (CART), peptides that promote weight loss and increase energy expenditure, or neuropeptide Y (NPY) and agouti-related protein (AGRP), peptides that promote weight gain and reduce energy expenditure. "
07/01/2022 - "During weight loss therapy, a decrease in energy stores activates appetite signaling pathways under the regulation of neuropeptides, including anorexigenic [corticotropin-releasing hormone, proopiomelanocortin (POMC), cholecystokinin (CCK), and cocaine- and amphetamine-regulated transcript] and orexigenic [agouti-related protein (AgRP), neuropeptide Y (NPY), and melanin-concentrating hormone] neuropeptides, which increase food intake and lead to failure in attaining weight loss goals. "
4. Obesity
5. AIDS-Related Complex (ARC)

Related Drugs and Biologics

1. Non-Receptor Type 1 Protein Tyrosine Phosphatase
2. Complementary DNA (cDNA)
3. Leptin
4. Neuropeptide Y
5. Messenger RNA (mRNA)
6. Pro-Opiomelanocortin (Proopiomelanocortin)
7. Cocaine (Cocaine HCl)
8. Amphetamine (Amfetamine)
9. Neuropeptides
10. Insulin (Novolin)

Related Therapies and Procedures

1. Therapeutics
2. Electroacupuncture
3. Spinal Injections