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CXCR3 Receptors

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CXCR receptors that are expressed on the surface of a number of cell types, including T-LYMPHOCYTES; NK CELLS; DENDRITIC CELLS; and a subset of B-LYMPHOCYTES. The receptors are activated by CHEMOKINE CXCL9; CHEMOKINE CXCL10; and CHEMOKINE CXCL11.

Also Known As:

Receptors, CXCR3; CMKBR3 Chemokine Receptors; CXC Chemokine Receptors 3; CXCR3 Receptor; Chemokine (C-C Motif) Receptor 3; Chemokine Receptors, CMKBR3; Receptor, CXCR3; Receptors, CMKBR3 Chemokine; Antigens, CD183; CD183 Antigens; CXC Chemokine Receptor 3

Networked: 215 relevant articles (2 outcomes, 18 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Lu, Bao: 12 articles (02/2011 - 12/2002)
2.	Gerard, Craig: 8 articles (04/2009 - 12/2002)
3.	Satoskar, Abhay R: 5 articles (01/2015 - 02/2005)
4.	Datta, Dipak: 5 articles (08/2012 - 10/2006)
5.	Strieter, Robert M: 5 articles (01/2010 - 06/2002)
6.	Oghumu, Steve: 4 articles (01/2015 - 01/2013)
7.	Waaga-Gasser, Ana Maria: 4 articles (08/2012 - 10/2006)
8.	Pal, Soumitro: 4 articles (08/2012 - 10/2006)
9.	Wasmuth, Hermann E: 4 articles (05/2012 - 07/2009)
10.	Trautwein, Christian: 4 articles (05/2012 - 07/2009)

Related Diseases

1.	Infection 02/15/2008 - "In the current study we used mice deficient for the CXCL10 receptor, CXCR3, to evaluate its role in leukocyte-mediated viral clearance of WNV infection within various CNS compartments. " 12/01/2008 - "Previous studies have implicated the chemokine receptor CXCR3 and its ligand CXCL10 in CD8(+) T cell trafficking in the brain and in the lethal disease following intracranial infection of mice with the LCMV-Traub strain. " 12/01/2015 - "Recently, it was shown that the chemokine receptor CXCR3 on T cells has an important role in their ability to localize infected cells and to control vaccinia virus infection. " 08/01/2013 - "However, expression of chemokine-receptor CXCR3 was significantly higher on total peripheral CD8(+) T-cells of CHB or CHC patients compared to HC (p<0.005) which may reflect the pervasive influence of a persistent viral infection, even when restricted to the liver. " 01/01/2013 - "Chemokine receptor CXCR3 is associated with Th1 responses, and here we use bicistronic CXCR3-eGFP knock-in reporter mice to demonstrate upregulation of this chemokine receptor on CD4⁺ and CD8⁺ T lymphocytes during Toxoplasma infection. "
2.	Exanthema (Rash) 06/01/1998 - "Moreover, by examining virus expression in sequential skin biopsies from the same animal, the clearance of virus and the resolution of rash were associated with an increase in the percentage of cells expressing CD8, the chemokine receptor CXCR3, and GMP-17, a marker of cytotoxic granules. "
3.	Neoplasms (Cancer) 08/01/2015 - "Inhibition of DPP4 enzymatic activity enhanced tumor rejection by preserving biologically active CXCL10 and increasing trafficking into the tumor by lymphocytes expressing the counter-receptor CXCR3. " 11/15/2014 - "Moreover, ATC cell lines produced high levels of CXCL10 and stimulated migration of expanded NK cells and ATC tumors were enriched for NK cells expressing the cognate chemokine receptor CXCR3. " 07/01/2012 - "Neutralizing CXCL10 antibody reduced migration of cancer cells expressing the CXCL10 receptor CXCR3, and loss of CXCR3 or CXCL10 decreased bone tumor burden in vivo. " 01/01/2012 - "The frequencies of cells expressing α4β7 and the Th1 associated chemokine receptor CXCR3 were significantly decreased among CD4⁺ T cells in the tumor, while frequencies of CD4⁺CCR4⁺ lymphocytes were significantly increased. " 10/01/2007 - "More lymphocytes were recruited to the site of tumor inoculated by 4T1-ITAC and more than 80% of these T cells expressed the ITAC receptor, CXCR3. "
4.	Inflammation 01/01/2016 - "CXC chemokine receptor 3 (CXCR3) is involved in virus-related chronic liver inflammation. " 06/01/2014 - "This chemokine is a ligand for the CXCR3 receptor and regulates immune responses by activating and recruiting leukocytes such as T cells, eosinophils, monocytes, and NK cells to sites of inflammation. " 03/20/2012 - "Chemokine receptor CXCR3 agonist prevents human T-cell migration in a humanized model of arthritic inflammation." 12/01/2011 - "Because the chemokine receptor CXCR3 participates in lymphocyte trafficking during hepatic inflammation, it may participate in the escalated liver disorders of coinfected patients. " 08/01/2011 - "Collectively, these results demonstrate that the peripheral homing receptor CXCR3 is expressed on subset(s) of circulating human Tregs and suggest a role for CXCR3 in their recruitment into peripheral sites of inflammation."
5.	Multiple Sclerosis 04/01/2002 - "Selective suppression of chemokine receptor CXCR3 expression by interferon-beta1a in multiple sclerosis." 03/20/2015 - "The CXC chemokine receptors 3 and 4 (CXCR3, CXCR4), which are investigated in this study, are linked to severe diseases such as cancer, multiple sclerosis, and HIV infections. " 01/01/2012 - "Recent studies strongly support that the CXCR3 receptor is a very attractive therapeutic target for treating autoimmune diseases, such as rheumatoid arthritis, multiple sclerosis and psoriasis, and to prevent transplant rejection. " 04/01/2000 - "Expression of the interferon-gamma-inducible chemokines IP-10 and Mig and their receptor, CXCR3, in multiple sclerosis lesions." 01/01/2005 - "The chemokines (CXCL9, CXCL10 and CXCL11) and associated CXCR3 receptor are expressed during the inflammatory process from multiple sclerosis, atherosclerosis or organ transplantation resulting in the recruitment of lymphocytes leading to tissue damage. "

Related Drugs and Biologics

1.	Ligands
2.	Chemokine CXCL10
3.	Chemokines
4.	Interferon-gamma (Interferon, gamma)
5.	CXC Chemokines
6.	Chemokine CXCL11
7.	Staphylococcal Protein A (A, Protein)
8.	Interleukin-16 (Interleukin 16)
9.	Nitric Oxide Synthase (NO Synthase)
10.	imiquimod (Aldara)

Related Therapies and Procedures

1.	Ligation
2.	Homologous Transplantation (Allograft)
3.	Transplantation (Transplant Recipients)
4.	Organ Transplantation
5.	Kidney Transplantation