Agouti Signaling Protein

A secreted protein of approximately 131 amino acids (depending on species) that regulates the synthesis of eumelanin (brown/black) pigments in MELANOCYTES. Agouti protein antagonizes the signaling of MELANOCORTIN RECEPTORS and has wide distribution including ADIPOSE TISSUE; GONADS; and HEART. Its overexpression in agouti mice results in uniform yellow coat color, OBESITY, and metabolic defects similar to type II diabetes in humans.

Also Known As:

Networked: 69 relevant articles (0 outcomes, 4 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Leibel, Rudolph L: 3 articles (05/2011 - 11/2002)
2.	Bazhan, N M: 2 articles (03/2016 - 09/2004)
3.	Barsh, Gregory S: 2 articles (02/2015 - 01/2012)
4.	David, Victor A: 2 articles (02/2015 - 01/2012)
5.	Eizirik, Eduardo: 2 articles (02/2015 - 01/2012)
6.	Menotti-Raymond, Marilyn: 2 articles (02/2015 - 01/2012)
7.	O'Brien, Stephen J: 2 articles (02/2015 - 01/2012)
8.	Schneider, Alexsandra: 2 articles (02/2015 - 01/2012)
9.	Wolff, George L: 2 articles (11/2007 - 10/2005)
10.	Nonogaki, Katsunori: 2 articles (05/2007 - 12/2006)

Related Diseases

1.	Melanoma (Melanoma, Malignant) 11/01/1995 - "This study demonstrates that murine agouti protein causes both a time- and concentration-dependent suppression of melanogenesis in B16 F1 murine melanoma cells. " 01/01/2013 - "Agouti signaling protein (ASIP) locus on chromosome 20q11 is implicated, as shown by genome-wide association studies, in phenotype variation and melanoma risk. " 03/01/2002 - "We sought to characterize the agouti signaling protein gene (ASIP) in a group of white subjects, to assess whether ASIP was a determinant of human pigmentation and whether this gene may be associated with increased melanoma risk. " 05/03/2016 - "Inhibition of MC1R by its physiologically relevant competitive inhibitor, agouti signaling protein (ASIP), reduced melanin synthesis and morphological heterogeneity in murine B16-F10 melanoma cells. " 08/01/2008 - "Gray horses carrying a loss-of-function mutation in ASIP (agouti signaling protein) had a higher incidence of melanoma, implying that increased melanocortin-1 receptor signaling promotes melanoma development in Gray horses. "
2.	Neoplasms (Cancer) 11/01/2007 - "In the present study, we ascertained whether agouti signaling protein (ASIP) levels in A(vy)/a or a/a livers are associated with hepatocyte proliferation as a possible factor in promotion of hepatocellular tumor formation. " 02/01/1996 - "Ectopic expression of the agouti protein results in enhanced susceptibility to tumor formation in tissues which are already sensitized to neoplastic transformation by their strain genome. " 05/01/1994 - "This review seeks to summarize the current state of knowledge regarding the obesity, stimulation of somatic growth, and enhancement of tumor formation caused by the A(vy) mutation, and to interpret these pleiotropic effects in terms of the normal function of the agouti protein."
3.	Bacterial Infections (Bacterial Infection) 04/12/2023 - "The aim of our study was to determine the impact of the severity of the disease and the type of bacterial infection in 38 CF patients on the serum level of appetite-regulating hormones including leptin, ghrelin, neuropeptide Y, agouti-signaling protein, proopiomelanocortin, kisspeptin, putative protein Y, and α-melanocyte-stimulating hormone. "
4.	Obesity 03/01/2016 - "It is assumed that the ectopic expression of agouti protein in Ay males may be involved in the protection of the testicular function from the negative impact of obesity." 01/01/2012 - "Beside its role in melanogenesis, the agouti signaling protein (ASIP) has been related to obesity. " 05/27/2011 - "The ubiquitous overexpression of agouti-signaling protein (ASP), a paracrine-signaling molecule that regulates pigment-type switching in the hair follicle of the mouse, is responsible for the obesity and yellow pelage of the Yellow mouse (A(y)). " 06/01/2007 - "Avy/agouti (Avy) mice have late onset obesity related to overexpression of agouti signaling protein (ASP) in the hypothalamus. " 09/01/2006 - "The hypomorphic allele suppresses the yellow pigmentation and obesity of the A(y) mouse that ubiquitously overexpresses agouti signaling protein (ASP). "
5.	Body Weight (Weight, Body) 06/01/1999 - "The larger mean brain weight and retention, during caloric restriction, of the somewhat greater prerestriction Avy/A mean body weight compared with prerestriction A/a mice were consonant with the hypothesis that ectopic agouti protein affects somatic growth directly or indirectly. " 12/01/2020 - "Overexpression of inverse agonists, agouti-signaling protein (ASIP), and agouti-related protein (AGRP) results in increased food intake, linear growth, and body weight. " 05/01/2007 - "Milnacipran suppressed food intake and body weight in wild-type mice and in A(y) mice, which have ectopic expression of the agouti protein. " 02/01/1998 - "Agouti protein and Agouti-related protein (Agrp) are paracrine-signaling molecules that normally regulate pigmentation and body weight, respectively. " 05/28/1999 - "Agouti protein and Agouti-related protein (Agrp) regulate pigmentation and body weight, respectively, by antagonizing melanocortin receptor signaling. "

Related Drugs and Biologics

1.	Melanocyte-Stimulating Hormones (MSH)
2.	Proteins (Proteins, Gene)
3.	Leptin
4.	Hormones (Hormone)
5.	Kisspeptins
6.	Neuropeptide Y
7.	Ghrelin
8.	Pro-Opiomelanocortin (Proopiomelanocortin)
9.	Ligands
10.	Melanocortin Receptors (Melanocortin Receptor)

Related Therapies and Procedures

1.	Therapeutics
2.	Caloric Restriction