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Perforin

A calcium-dependent pore-forming protein synthesized in cytolytic LYMPHOCYTES and sequestered in secretory granules. Upon immunological reaction between a cytolytic lymphocyte and a target cell, perforin is released at the plasma membrane and polymerizes into transmembrane tubules (forming pores) which lead to death of a target cell.
Also Known As:
Perforin 1; Lymphocyte Pore Forming Protein; Pore-Forming Protein, Lymphocyte; Cytolysin; Lymphocyte Pore-Forming Protein
Networked: 2000 relevant articles (79 outcomes, 152 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Smyth, Mark J: 37 articles (01/2015 - 01/2002)
2. Trapani, Joseph A: 22 articles (01/2019 - 03/2002)
3. Voskoboinik, Ilia: 16 articles (01/2022 - 09/2004)
4. Froelich, Christopher J: 12 articles (02/2017 - 10/2002)
5. Yagita, Hideo: 9 articles (01/2018 - 01/2002)
6. Simon, Markus M: 9 articles (02/2017 - 10/2002)
7. Jordan, Michael B: 9 articles (07/2015 - 08/2004)
8. Hayakawa, Yoshihiro: 9 articles (01/2009 - 11/2002)
9. Smyth, M J: 9 articles (08/2001 - 04/2000)
10. Darcy, Phillip K: 8 articles (01/2019 - 01/2002)

Related Diseases

1. Neoplasms (Cancer)
2. Infections
3. Leukemia
4. Virus Diseases (Viral Diseases)
5. Retinitis

Related Drugs and Biologics

1. Granzymes (Granzyme)
2. Proteins (Proteins, Gene)
3. Interferon-gamma (Interferon, gamma)
4. Cytokines
5. Interleukin-2 (IL2)
6. Neutralizing Antibodies
7. Antigens
8. Interferons
9. T-Cell Antigen Receptors (T-Cell Receptor)
10. Messenger RNA (mRNA)

Related Therapies and Procedures

1. Immunotherapy
2. Drug Therapy (Chemotherapy)
3. Analgesia
4. Therapeutics
5. Transplantation