Human Immunodeficiency Virus tat Gene Products

Proteins encoded by the TAT GENES of the HUMAN IMMUNODEFICIENCY VIRUS.

Also Known As:

tat Gene Products, Human Immunodeficiency Virus; Trans Acting Transcription Factor, HIV; tat Protein, HIV; HIV Transacting Transcription Protein; HIV tat Protein; Trans-Acting Transcription Factor, HIV

Networked: 53 relevant articles (1 outcomes, 7 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843

Experts

1.	Nath, Avindra: 5 articles (11/2014 - 04/2003)
2.	McLaughlin, Jay P: 2 articles (06/2022 - 04/2012)
3.	Bai, Yunlong: 2 articles (12/2021 - 01/2018)
4.	Chai, Lu: 2 articles (12/2021 - 01/2018)
5.	Fasae, Moyondafoluwa Blessing: 2 articles (12/2021 - 01/2018)
6.	Buch, Shilpa: 2 articles (01/2021 - 01/2015)
7.	Niu, Fang: 2 articles (01/2021 - 01/2015)
8.	Moodley, Jagidesa: 2 articles (08/2020 - 01/2019)
9.	Naicker, Thajasvarie: 2 articles (08/2020 - 01/2019)
10.	Toborek, Michal: 2 articles (05/2009 - 02/2005)

Related Diseases

1.	Pancreatic Neoplasms (Pancreatic Cancer) 12/01/2005 - "Here we report that fusion of TK to an eight-amino acid peptide from the basic domain of the human immunodeficiency virus (HIV) Tat protein significantly increases the cytotoxic efficacy of the TK/GCV system in pancreatic cancer cells. "
2.	HIV Infections (HIV Infection) 11/01/2004 - "To study the effects of HIV Tat protein on CCR5 expression of monocytes and HIV infection in monocytes. " 11/01/2011 - "HIV Tat protein inhibits hERG K+ channels: a potential mechanism of HIV infection induced LQTs." 02/18/2005 - "The human immunodeficiency virus (HIV)-Tat protein has been implicated in the neuropathogenesis of HIV infection. " 02/01/2005 - "(3) The current review discusses the mechanisms of injury to brain endothelial cells and alterations of the BBB integrity in HIV-infection with focus on the vascular effects of HIV Tat protein. " 04/11/2003 - "The human immunodeficiency virus (HIV)-Tat protein has been implicated in the neuropathogenesis of HIV infection. "
3.	Acquired Immunodeficiency Syndrome (AIDS) 10/01/2014 - "The purpose of this study was to test the hypothesis that the sleep quality of patients with HIV/AIDS affected by an altered circadian rhythm correlates with cerebrospinal HIV Tat protein concentration. " 10/01/2000 - "The HIV Tat protein appears to be responsible for the highly aggressive nature of AIDS-KS. " 12/01/1998 - "CDK9 has been shown to associate with the HIV-Tat protein, suggesting a possible involvement in AIDS. " 10/01/2014 - "The HIV Tat protein affects circadian rhythmicity by interfering with the circadian system in patients with HIV/AIDS and further increases the melatonin excretion value. " 04/01/2008 - "We herein report that sulfated polymannuroguluronate (SPMG), a novel anti-acquired immunodeficiency syndrome drug candidate now in phase II clinical trial, significantly decreased vulnerability of PC12 cells to HIV Tat protein by protecting cells from apoptosis. "
4.	Neoplasms (Cancer) 10/31/2008 - "HIV-tat protein, HIV-induced immune suppression and a hyperinflammatory state facilitate the oncogenic activity of HHV-8.In this article we reviewed some aspects of HIV-KS pathogenesis and tried to establish, according to the available information in the literature, whether HIV-KS is a monoclonal neoplasm or a benign angioproliferative disorder.From" 03/01/2002 - "Herein we demonstrate that a bacterial recombinant model tumor-associated Ag (OVA) that contains the HIV TAT protein transduction domain (PTD) was readily engineered and purified, efficiently transduced murine lymphocytes and DC, and was processed by proteasomes for MHC class I-restricted presentation to CTL. " 05/15/2009 - "The feasibility of this technique has been validated by infusion of HIV Tat protein to induce permeability of the blood-brain barrier and by implantation of tumor cells to establish a brain metastasis model. " 01/01/2006 - "Further, we present the hypothesis that HIV-Tat protein might have a close relationship with meningioma pathogenesis and malignancy." 02/01/2007 - "HIV-Tat protein transduction domain specifically attenuates growth of polyamine deprived tumor cells."
5.	Kidney Neoplasms (Kidney Cancer) 03/01/2001 - "In the present study, the amino acid sequence (104-123) of the pVHL was conjugated to the protein transduction domain of HIV-TAT protein (TATFLAGVHL-peptide) to facilitate entry into cells, and we demonstrate that this amino acid region of VHL is sufficient to block proliferation and invasion of 786-O renal cancer cells in vitro. "

Related Drugs and Biologics

1.	Peptides (Polypeptides)
2.	Amino Acids
3.	Proteins (Proteins, Gene)
4.	Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)
5.	Peptide Hydrolases (Proteases)
6.	Carrier Proteins (Binding Protein)
7.	Trans-Activators (Trans-Acting Factor)
8.	Notch Receptors
9.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
10.	Transcription Factor AP-1 (Transcription Factor AP 1)

Related Therapies and Procedures

1.	Highly Active Antiretroviral Therapy (HAART)
2.	Therapeutics