Marchiafava-Bignami Disease

A neurodegenerative condition that is characterized by demyelination or necrosis of the CORPUS CALLOSUM. Symptoms include DEPRESSION; PARANOIA; DEMENTIA; SEIZURES; and ATAXIA which can progress to COMA and death in a few months. Marchiafava-Bignami syndrome is seen often in alcoholics but has been found in non-alcoholics as well.

Also Known As:

Networked: 18 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Wernicke Encephalopathy (Wernicke's Encephalopathy)
2.	Malnutrition
3.	Central Pontine Myelinolysis
4.	Pellagra
5.	Infection

Experts

1.	Tung, Alan: 1 article (05/2015)
2.	Henderson, Cynthia: 1 article (05/2015)
3.	Vaghadia, Himat: 1 article (05/2015)
4.	Ozbek, Damla: 1 article (01/2015)
5.	Kilinc, Ozden: 1 article (01/2015)
6.	Midi, Ipek: 1 article (01/2015)
7.	Ozkan, Esra: 1 article (01/2015)
8.	Shin, Dong Jae: 1 article (04/2014)
9.	Young, Jeong Bo: 1 article (04/2014)
10.	Kim, Tae Eun: 1 article (04/2014)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Marchiafava-Bignami Disease:

1.	Vitamin B Complex (B Vitamins)IBA 03/01/2013 - "The present article is a case report of a severe acute form of Marchiafava-Bignami disease in an alcohol-dependent male patient who improved after the administration of parenteral B vitamins. "
2.	VitaminsIBA 02/01/2003 - "The first MR imaging study showed extensive abnormal signal intensity of the corpus callosum without macroscopic changes; a diagnosis of Marchiafava-Bignami disease was made, and vitamin therapy was initiated. "
3.	Ethanol (Ethyl Alcohol)IBA 03/01/2013 - "Marchiafava-Bignami disease is a rare affliction characterized by primary degeneration of the corpus callosum associated with chronic consumption of ethanol. " 08/01/1996 - "Marchiafava-Bignami disease is a complication of chronic ethanol intoxication. " 02/01/1993 - "Distinguishing ethanol neurotoxicity from nutritional deficiency can be facilitated by magnetic resonance imaging, which can visualize some of the specific macroscopic lesions of Wernicke's encephalopathy, central pontine myelinolysis, cerebellar degeneration, and Marchiafava-Bignami syndrome. " 04/01/2014 - "This review provides an overview of Wernicke encephalopathy and other ethanol-related brain changes, such as chronic brain atrophy, Marchiafava-Bignami disease, osmotic demyelination syndrome, chronic hepatic encephalopathy, and acute alcohol withdrawal. " 02/01/1993 - "Ethanol neurotoxicity, Wernicke's encephalopathy, hepatocerebral degeneration, head trauma, central pontine myelinolysis, Marchiafava-Bignami syndrome, pellagra, and premorbid pathological conditions, such as fetal alcohol syndrome, may all contribute to cognitive dysfunction in alcoholics. "
4.	Thiamine (Aneurin)FDA Link 01/01/2011 - "A case of marchiafava bignami disease: complete recovery with thiamine." 05/01/2004 - "[Rapid improvement of callosal edema by thiamine administration in Marchiafava-Bignami disease: a case report]."
5.	Glucose (Dextrose)FDA LinkGeneric 08/01/1999 - "Regional cerebral glucose metabolism and blood flow in a patient with Marchiafava-Bignami disease." 01/01/1994 - "The Cerebral Metabolic Rate of Glucose (CMRGlu) was measured with positron emission tomography and 18F-FDG in a patient with Marchiafava-Bignami Disease (MBD)-related dementia. "
6.	Fluorodeoxyglucose F18 (Fludeoxyglucose F 18)FDA Link 01/01/1994 - "The Cerebral Metabolic Rate of Glucose (CMRGlu) was measured with positron emission tomography and 18F-FDG in a patient with Marchiafava-Bignami Disease (MBD)-related dementia. "
7.	Hemoglobins (Hemoglobin)IBA 09/01/2010 - "Marchiafava-Bignami disease complicating SC hemoglobin disease and Plasmodium falciparum infection."
8.	CortisoneIBA 06/01/2003 - "Use of high-dose cortisone in a patient with Marchiafava-Bignami disease."
9.	Contrast MediaIBA 10/01/1994 - "Marchiafava-Bignami disease: use of contrast media in CT and MRI."
10.	Blood Glucose (Blood Sugar)IBA 01/01/2015 - "Neurological and psychiatric findings of marchiafava-bignami disease in a nonalcoholic diabetic patient with high blood glucose levels."

Therapies and Procedures

1.	Split-Brain Procedure (Split-Brain) 01/01/2011 - "Acute, non-lethal Marchiafava-Bignami disease with reversible posterior leucoencephalopathy and split-brain syndrome." 10/20/1994 - "Incomplete split-brain syndrome in a patient with chronic Marchiafava-Bignami disease."
2.	Spinal Anesthesia 05/01/2015 - "Spinal anesthesia in a patient with Marchiafava-Bignami disease."