HIV Reverse Transcriptase

A reverse transcriptase encoded by the POL GENE of HIV. It is a heterodimer of 66 kDa and 51 kDa subunits that are derived from a common precursor protein. The heterodimer also includes an RNAse H activity (RIBONUCLEASE H, HUMAN IMMUNODEFICIENCY VIRUS) that plays an essential role the viral replication process.

Also Known As:

Networked: 79 relevant articles (4 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Ng, T B: 4 articles (02/2009 - 03/2000)
2.	Ye, X Y: 3 articles (04/2001 - 03/2000)
3.	Aravantinou, Meropi: 2 articles (09/2012 - 09/2008)
4.	Blanchard, James: 2 articles (09/2012 - 09/2008)
5.	Gettie, Agegnehu: 2 articles (09/2012 - 09/2008)
6.	Kenney, Jessica: 2 articles (09/2012 - 09/2008)
7.	Lifson, Jeffrey D: 2 articles (09/2012 - 09/2008)
8.	Piatak, Michael: 2 articles (09/2012 - 09/2008)
9.	Robbiani, Melissa: 2 articles (09/2012 - 09/2008)
10.	Douglas, Steven D: 2 articles (11/2010 - 03/2007)

Related Diseases

1.	HIV Infections (HIV Infection) 05/02/2019 - "Compounds 6a-c, characterized by the presence of an ethereal group at C-3, show HIV reverse transcriptase (RT) inhibitor activity in the nanomolar range as well as HIV-infection inhibitor activity in the low micromolar with no toxicity. " 06/01/2010 - "Following HIV infection with NL4-3 or AD8 in hepatic cell lines, we observed a significant increase in HIV reverse transcriptase activity which was infectious. " 06/01/2001 - "Inhibitors of human immunodeficiency virus (HIV) reverse transcriptase (RT) are widely used in the treatment of HIV infection. " 12/16/1996 - "Both drugs are potent inhibitors of the human immunodeficiency virus (HIV) reverse transcriptase and are used in the therapy of HIV infection. " 08/28/2008 - "Owing to the emergence of resistant virus, next generation non-nucleoside HIV reverse transcriptase inhibitors (NNRTIs) with improved drug resistance profiles have been developed to treat HIV infection. "
2.	Infections 12/01/2014 - "HIV reverse-transcriptase drug resistance mutations during early infection reveal greater transmission diversity than in envelope sequences." 01/01/2014 - "Drugs licensed for inhibition of HIV reverse transcriptase lower the viral load of chronic HBV patients, but they do not cure the infection. " 09/08/2008 - "Since dendritic cells (DCs) are believed to be important in HIV transmission, the formulations were tested for the ability to limit DC-driven infection in vitro versus vaginal infection of macaques with RT-SHIV (SIVmac239 bearing HIV reverse transcriptase). " 10/01/2003 - "Live MAC (infection) consistently increased HIV reverse transcriptase (RT) activity by more than 3-fold. " 12/10/2000 - "HIV reverse transcriptase (RT) is immunologically recognized by the host after natural infection with HIV. "
3.	AIDS-Related Complex (ARC) 12/01/1995 - "To evaluate the efficacy of 3TC (lamivudine), a synthetic nucleoside analogue that inhibits HIV reverse transcriptase in vitro, as treatment for HIV-positive, asymptomatic or mild AIDS-related complex patients. "
4.	Acquired Immunodeficiency Syndrome (AIDS) 10/01/2015 - "HIV reverse transcriptase gene mutations in anti-retroviral treatment naïve rural people living with HIV/AIDS." 12/01/2009 - "HIV reverse transcriptase (RT) is a primary target for drug intervention in the treatment of AIDS. " 08/01/1999 - "Inhibitors of HIV reverse transcriptase (RT) are important drugs for the treatment of acquired immuno-deficiency syndrome (AIDS). " 08/01/1993 - "The application of this new method of drug targeting is macrophage selective inhibition of HIV-reverse transcriptase in AIDS." 07/02/1991 - "HIV reverse transcriptase (RT) is the target of the most widely used treatments for AIDS. "
5.	Neoplasms (Cancer) 08/01/2012 - "The HIV reverse transcriptase inhibitor tenofovir induces cell cycle arrest in human cancer cells." 02/15/2011 - "Yet none of these tested compounds have obvious inhibition against glycosidases or HIV reverse transcriptase, or show cancer cell growth inhibition." 03/01/2004 - "To test the effect of 2'-deoxyisoguanosine as a specific substrate of HIV reverse transcriptase on the growth of cultured normal and cancer cells. " 08/01/2012 - "Here, we show that the HIV reverse transcriptase inhibitor Truvada, a combination drug of the cytidine analogue emtricitabine and the adenosine analogue tenofovir, induces DNA damage and cell cycle arrest in human cancer cells. " 09/01/1998 - "beta, human immunodeficiency virus type 1 reverse transcriptase (HIV-RT), and calf thymus terminal deoxynucleotidyl transferase (TdT) in vitro, and did not influence the activities of prokaryotic DNA polymerases such as Klenow Fragment of DNA polymerase I, or the DNA-metabolic enzyme DNase I. HMI was found to be able to prevent the growth of human cancer cell lines originating from patients with leukemia or various solid tumors; its IC50 values ranged from 7.5 to 12 microM. "

Related Drugs and Biologics

1.	Nucleosides
2.	HIV Protease Inhibitors
3.	Nucleotides
4.	Lamivudine (Epivir)
5.	efavirenz (Sustiva)
6.	calanolide A
7.	Tenofovir (Viread)
8.	Peptide Hydrolases (Proteases)
9.	Enzymes
10.	Zidovudine (Retrovir)

Related Therapies and Procedures

1.	Low-Level Light Therapy (LLLT)
2.	Therapeutics
3.	Highly Active Antiretroviral Therapy (HAART)
4.	Drug Therapy (Chemotherapy)