Classical Lissencephalies and Subcortical Band Heterotopias

Disorders comprising a spectrum of brain malformations representing the paradigm of a diffuse neuronal migration disorder. They result in cognitive impairment; SEIZURES; and HYPOTONIA or spasticity. Mutations of two genes, LIS1, the gene for the non-catalytic subunit of PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE IB; and DCX or XLIS, the gene for doublecortin, have been identified as the most common causes of disorders in this spectrum. Additional variants of classical (Type I) lissencephaly have been linked to RELN, the gene for reelin, and ARX, the gene for aristaless related homeobox protein. (From Leventer, R.J., et al, Mol Med Today. 2000 Jul;6(7):277-84 and Barkovich, A.J., et al, Neurology. 2005 Dec 27;65(12):1873-87.)
Also Known As:
Agyria-Pachygyria-Band Spectrum; Double Cortex Syndrome; Isolated Lissencephaly Sequence; Lissencephaly Syndrome, Miller-Dieker; Lissencephaly, Miller-Dieker; Subcortical Laminar Heterotopia; Type 1 Lissencephaly; X-Linked Lissencephaly; Agyria Pachygyria Band Spectrum; Band Heterotopia, Lissencephaly-Subcortical; Classical Lissencephalies; Classical Lissencephaly; Heterotopia, Lissencephaly-Subcortical Band; Heterotopia, Subcortical Laminar; Heterotopias, Lissencephaly-Subcortical Band; Heterotopias, Subcortical Band; Heterotopias, Subcortical Laminar; Lissencephalies, Type 1; Lissencephalies, X-Linked; Lissencephaly Subcortical Band Heterotopia; Lissencephaly Syndrome, Miller Dieker; Lissencephaly, Classical; Lissencephaly, Miller Dieker; Lissencephaly, X Linked; Lissencephaly-Subcortical Band Heterotopias; Miller Dieker Syndrome; Miller-Dieker Lissencephaly; Miller-Dieker Lissencephaly Syndrome; Subcortical Band Heterotopias; Syndrome, Double Cortex; Syndrome, Miller-Dieker; Syndrome, Miller-Dieker Lissencephaly; Type 1 Lissencephalies; X Linked Lissencephaly; X-Linked Lissencephalies; Heterotopia, Subcortical Band; Lissencephalies, Classical; Lissencephaly, Type 1; Lissencephaly, X-Linked; Lissencephaly-Subcortical Band Heterotopia; Miller-Dieker Syndrome; Subcortical Band Heterotopia
Networked: 101 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Seizures (Seizure)
2. Classical Lissencephalies and Subcortical Band Heterotopias
3. Lissencephaly
4. Epilepsy (Aura)
5. Mental Retardation (Idiocy)


1. Itoh, Masayuki: 3 articles (01/2015 - 10/2008)
2. Cappello, Silvia: 3 articles (01/2014 - 03/2012)
3. Miyata, Rie: 2 articles (01/2015 - 09/2010)
4. Hayashi, Masaharu: 2 articles (01/2015 - 09/2010)
5. Akashi, Takumi: 2 articles (01/2015 - 09/2010)
6. Scheffer, Ingrid E: 2 articles (08/2014 - 04/2003)
7. Berkovic, Samuel F: 2 articles (08/2014 - 04/2003)
8. Sugai, Kenji: 2 articles (08/2014 - 02/2009)
9. Sasaki, Masayuki: 2 articles (08/2014 - 02/2009)
10. Sato, Noriko: 2 articles (08/2014 - 02/2009)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Classical Lissencephalies and Subcortical Band Heterotopias:
1. lamotrigine (Lamictal)FDA LinkGeneric
2. Double cortexIBA
3. Nonsense Codon (Nonsense Mutation)IBA
4. Platelet Activating FactorIBA
5. DNA (Deoxyribonucleic Acid)IBA
6. Genetic Markers (Genetic Marker)IBA
7. X-linked infantile spasm syndromeIBA
8. Partington X-linked mental retardation syndromeIBA
9. Transcription Factors (Transcription Factor)IBA
10. Dyneins (Dynein)IBA

Therapies and Procedures

1. Vagus Nerve Stimulation
2. Ligation
3. Anesthesia