Classical Lissencephalies and Subcortical Band Heterotopias

Disorders comprising a spectrum of brain malformations representing the paradigm of a diffuse neuronal migration disorder. They result in cognitive impairment; SEIZURES; and HYPOTONIA or spasticity. Mutations of two genes, LIS1, the gene for the non-catalytic subunit of PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE IB; and DCX or XLIS, the gene for doublecortin, have been identified as the most common causes of disorders in this spectrum. Additional variants of classical (Type I) lissencephaly have been linked to RELN, the gene for reelin, and ARX, the gene for aristaless related homeobox protein. (From Leventer, R.J., et al, Mol Med Today. 2000 Jul;6(7):277-84 and Barkovich, A.J., et al, Neurology. 2005 Dec 27;65(12):1873-87.)
Also Known As:
Agyria-Pachygyria-Band Spectrum; Chromosome 17p13.3 Deletion Syndrome; Classic Lissencephaly; Classical Lissencephaly Syndrome; Double Cortex Syndrome; Isolated Lissencephaly Sequence; Lissencephaly 1; Lissencephaly Sequence, Isolated; Lissencephaly Syndrome, Miller-Dieker; Lissencephaly Type 1; Lissencephaly, Classic; Lissencephaly, Miller-Dieker; Lissencephaly, X-Linked, 1; Miller-Dieker Lissencephaly Syndrome; Subcortical Laminar Heterotopia; Type 1 Lissencephaly; X-Linked Lissencephaly; 1, Lissencephaly; 1, Lissencephaly Type; 1s, Lissencephaly; 1s, Lissencephaly Type; Agyria Pachygyria Band Spectrum; Band Heterotopia, Lissencephaly-Subcortical; Classic Lissencephalies; Classical Lissencephalies; Classical Lissencephaly; Classical Lissencephaly Syndromes; Heterotopia, Lissencephaly-Subcortical Band; Heterotopia, Subcortical Laminar; Heterotopias, Lissencephaly-Subcortical Band; Heterotopias, Subcortical Band; Heterotopias, Subcortical Laminar; Lissencephalies, Classic; Lissencephalies, Type 1; Lissencephalies, X-Linked; Lissencephaly 1s; Lissencephaly Subcortical Band Heterotopia; Lissencephaly Syndrome, Classical; Lissencephaly Syndrome, Miller Dieker; Lissencephaly Syndromes, Classical; Lissencephaly Type 1s; Lissencephaly, Classical; Lissencephaly, Miller Dieker; Lissencephaly, X Linked; Lissencephaly-Subcortical Band Heterotopias; Miller Dieker Lissencephaly Syndrome; Miller Dieker Syndrome; Miller-Dieker Lissencephaly; Subcortical Band Heterotopias; Syndrome, Classical Lissencephaly; Syndrome, Double Cortex; Syndrome, Miller-Dieker; Syndrome, Miller-Dieker Lissencephaly; Syndromes, Classical Lissencephaly; Type 1 Lissencephalies; Type 1, Lissencephaly; Type 1s, Lissencephaly; X Linked Lissencephaly; X-Linked Lissencephalies; Heterotopia, Subcortical Band; Lissencephalies, Classical; Lissencephaly, Type 1; Lissencephaly, X-Linked; Lissencephaly-Subcortical Band Heterotopia; Miller-Dieker Syndrome; Subcortical Band Heterotopia
Networked: 126 relevant articles (1 outcomes, 4 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Seizures (Absence Seizure)
2. Neurodevelopmental Disorders
3. Classical Lissencephalies and Subcortical Band Heterotopias
4. Lissencephaly
5. Group II Malformations of Cortical Development


1. Cappello, Silvia: 3 articles (01/2014 - 03/2012)
2. Uyanik, G: 3 articles (11/2008 - 06/2004)
3. Fu, Xiaoqin: 2 articles (01/2021 - 01/2013)
4. Liu, Judy S: 2 articles (01/2021 - 01/2013)
5. Baraban, Scott C: 2 articles (01/2017 - 08/2009)
6. Melaragno, Maria I: 2 articles (01/2017 - 07/2006)
7. Shoubridge, Cheryl: 2 articles (05/2016 - 01/2010)
8. Kato, Mitsuhiro: 2 articles (01/2016 - 04/2005)
9. Itoh, Masayuki: 2 articles (01/2015 - 10/2008)
10. Götz, Magdalena: 2 articles (01/2014 - 03/2012)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Classical Lissencephalies and Subcortical Band Heterotopias:
1. Lamotrigine (Lamictal)FDA LinkGeneric
2. Proteins (Proteins, Gene)FDA Link
3. Nonsense Codon (Nonsense Mutation)IBA
4. Technetium-99IBA
5. Dyneins (Dynein)IBA
6. Platelet Activating FactorIBA
7. Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA
8. DNA (Deoxyribonucleic Acid)IBA
9. 1-Alkyl-2-acetylglycerophosphocholine Esterase (PAF Acetylhydrolase)IBA
10. TubulinIBA

Therapies and Procedures

1. Therapeutics
2. Vagus Nerve Stimulation
3. Central Venous Catheters
4. Deep Brain Stimulation
5. Ligation