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Neonatal Alloimmune Thrombocytopenia

A condition in newborns caused by immunity of the mother to PLATELET ALLOANTIGENS on the fetal platelets. The PLATELETS, coated with maternal ANTIBODIES, are destroyed and removed by the fetal MONONUCLEAR PHAGOCYTE SYSTEM. Affected infants may have INTRACRANIAL HEMORRHAGES.
Also Known As:
Thrombocytopenia, Neonatal Alloimmune; Alloimmune Thrombocytopenia, Neonatal; Alloimmune Thrombocytopenias, Neonatal; Neonatal Alloimmune Thrombocytopenias; Neonatal Thrombocytopenias; Thrombocytopenia, Neonatal; Thrombocytopenias, Neonatal; Thrombocytopenias, Neonatal Alloimmune; Neonatal Thrombocytopenia
Networked: 661 relevant articles (19 outcomes, 39 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Thrombocytopenia (Thrombopenia)
2. Intracranial Hemorrhages (Intracranial Hemorrhage)
3. Idiopathic Thrombocytopenic Purpura (Thrombocytopenic Purpura, Autoimmune)
4. Hemorrhage
5. Thrombasthenia (Glanzmann Thrombasthenia)

Experts

1. Santoso, Sentot: 32 articles (01/2022 - 02/2002)
2. Bein, Gregor: 19 articles (01/2022 - 02/2009)
3. Husebekk, Anne: 17 articles (07/2020 - 08/2005)
4. Sachs, Ulrich J: 15 articles (01/2022 - 11/2011)
5. Curtis, Brian R: 14 articles (02/2020 - 08/2004)
6. Kjeldsen-Kragh, Jens: 13 articles (05/2022 - 06/2008)
7. Skogen, Bjørn: 13 articles (01/2022 - 06/2008)
8. Ahlen, Maria Therese: 11 articles (01/2022 - 04/2009)
9. Aster, Richard H: 11 articles (11/2019 - 08/2004)
10. Bakchoul, Tamam: 10 articles (01/2020 - 02/2009)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Neonatal Alloimmune Thrombocytopenia:
1. Intravenous Immunoglobulins (IVIG)FDA Link
2. AntibodiesIBA
3. Inosine Triphosphate (ITP)IBA
4. human ITGB3 protein (HPA-1a)IBA
5. Immunoglobulin G (IgG)IBA
6. Prednisone (Sone)FDA LinkGeneric
10/01/2016 - "Specifically, we sought to determine whether intensive intravenous gammaglobulin-based regimens for the treatment of a subsequent fetal-neonatal alloimmune thrombocytopenia-affected pregnancy followed by empirically escalated intravenous gammaglobulin and prednisone treatment would increase the fetal platelet count and thus safely allow omission of fetal blood sampling in the antepartum management of these patients. "
10/01/2016 - "In this prospective, multicenter, randomized controlled study, 99 women with fetal-neonatal alloimmune thrombocytopenia whose prior affected child did not have an intracranial hemorrhage were randomized to receive an intensive intravenous gammaglobulin-based regimen: 2 g/kg per week or intravenous gammaglobulin 1 g/kg per week plus prednisone 0.5 mg/kg per day, starting at 20-30 weeks of gestation. "
01/01/2017 - "Low-dose prednisone and immunoglobulin G treatment for woman at risk for neonatal alloimmune thrombocytopenia and T helper 1 immunity."
07/01/2017 - "Background  Treatment for neonatal alloimmune thrombocytopenia (NAIT) primarily involves maternal administration of intravenous immunoglobulin (IVIG) therapy and prednisone according to protocols based on risk stratification. "
01/01/2021 - "Current management of fetal and neonatal alloimmune thrombocytopenia in a subsequent affected pregnancy involves antenatal administration of intravenous immune globulin and prednisone to the pregnant woman to prevent the development of severe fetal thrombocytopenia and secondary intracranial hemorrhage in utero. "
7. gamma-Globulins (gamma-Globulin)IBA
8. DNA (Deoxyribonucleic Acid)IBA
9. Prednisolone (Predate)FDA LinkGeneric
10. SuspensionsIBA

Therapies and Procedures

1. Therapeutics
2. Platelet Transfusion (Blood Platelet Transfusions)
3. Splenectomy
4. Transplantation
5. Cesarean Section (Caesarean Section)