Neuronal Migration Disorders

Disorders resulting from defects in migration of neuronal cells during neurogenesis. Developing nerve cells either fail to migrate or they migrate to incorrect positions resulting in formation of heterotopias, lissencephaly, or other malformations and dysfunctions of the nervous system.

Also Known As:

Networked: 67 relevant articles (0 outcomes, 5 trials/studies)

Disease Context: Research Results

Related Diseases

1.	Epilepsy (Aura)
2.	Seizures (Seizure)
3.	Classical Lissencephalies and Subcortical Band Heterotopias
4.	Lissencephaly
5.	Mental Retardation (Idiocy)

Experts

1.	Blake, Derek J: 3 articles (08/2012 - 11/2002)
2.	Luhmann, Heiko J: 2 articles (01/2015 - 03/2005)
3.	Brown, Susan C: 2 articles (08/2012 - 11/2002)
4.	Kim, Myeong-Kyu: 2 articles (08/2005 - 06/2004)
5.	Lee, Min-Cheol: 2 articles (08/2005 - 06/2004)
6.	Kim, Jin-Hee: 2 articles (08/2005 - 06/2004)
7.	Leroux, Philippe: 2 articles (02/2005 - 02/2005)
8.	Hennebert, Olivier: 2 articles (02/2005 - 02/2005)
9.	Laudenbach, Vincent: 2 articles (02/2005 - 02/2005)
10.	Marret, Stéphane: 2 articles (02/2005 - 02/2005)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Neuronal Migration Disorders:

1.	Double cortexIBA 08/15/1997 - "This study describes a novel neurologically mutant rat exhibiting a forebrain anomaly resembling the human neuronal migration disorder of double cortex. " 09/01/2009 - "Cranial magnetic resonance and diffusion tensor imaging detected a severe neuronal migration disorder with double cortex formation and pronounced reduction of the fronto-occipital tract system. " 12/01/1996 - "During migration of supragranular neurons, newborn hamsters intracerebrally injected at PO with ibotenate display neuronal migration disorders graded from nodular heterotopias to extensive laminar heterotopias mimicking some aspects of lissencephalic and double-cortex syndromes. " 01/01/1992 - "Band heterotopia, or "double cortex," is a neuronal migration disorder that consists of a symmetrical subcortical neuronal band. " 11/01/2011 - "When the chemotactants of our cells are not numerous enough, subcortical cell heterotopias will occur, at the level of the corona radiata, double cortex and other neuronal migration disorders which may generate epilepsy. "
2.	Glutamic Acid (Glutamate)FDA Link 12/01/1996 - "This study emphasizes the dramatic role played by glutamate in brain development, in the occurrence of neuronal migration disorders in the cortex, and in grey and white matter damage." 01/01/2015 - "Pharmacological or genetic manipulation of glutamate or GABA receptors during early corticogenesis induce heterotopic cell clusters in upper layers and loss of cortical lamination, i.e., neuronal migration disorders which can be associated with neurological or neuropsychiatric diseases. " 10/01/1998 - "Characterization of neuronal migration disorders in neocortical structures: quantitative receptor autoradiography of ionotropic glutamate, GABA(A) and GABA(B) receptors."
3.	VimentinIBA 02/01/2004 - "Radial and tangential neuronal migration disorder in ibotenate-induced cortical lesions in hamsters: immunohistochemical study of reelin, vimentin, and calretinin." 02/01/2004 - "To investigate the mechanisms of radial and tangential neuronal migration disorders, immunohistochemical expressions of reelin, vimentin, and calretinin were examined in brain lesions induced by ibotenate (an agonist of the N-methyl-D-aspartate [NMDA] complex receptor) in hamsters. "
4.	NeurotoxinsIBA 02/01/2005 - "The aim of the study was to determine the effects of in utero alcohol exposure on excitotoxin-induced neuronal migration disorders. "
5.	Anticonvulsants (Antiepileptic Drugs)IBA 03/01/2014 - "We recruited 69 patients in a prospective, open-label, add-on treatment study from six Italian and one German centers for pediatric and adolescent epilepsy care according to the following criteria: age 3 or above; focal or generalized seizures refractory to at least three previous antiepileptic drugs (AEDs), alone or in combination, secondary to neuronal migration disorders; two or more seizures per month in the last 6 months; use of another AED, but no more than three, at baseline. "
6.	calretininIBA 02/01/2004 - "Radial and tangential neuronal migration disorder in ibotenate-induced cortical lesions in hamsters: immunohistochemical study of reelin, vimentin, and calretinin." 02/01/2004 - "To investigate the mechanisms of radial and tangential neuronal migration disorders, immunohistochemical expressions of reelin, vimentin, and calretinin were examined in brain lesions induced by ibotenate (an agonist of the N-methyl-D-aspartate [NMDA] complex receptor) in hamsters. "
7.	N-Methylaspartate (NMDA)IBA 12/01/2015 - "Various CNS disease models, such as Alzheimer's disease (AD), Parkinson's disease (PD), multiple sclerosis (MS), epilepsy, N-methyl-D-aspartate receptor (NMDAR) encephalitis, migraine, diffuse axonal injury, and neuronal migration disorders, have been successfully established on microplatforms. " 03/01/2005 - "Morphologically identified pyramidal neurons recorded in MK801-treated cortex revealed late NMDA receptor-mediated synaptic inputs and fragile monosynaptic responses at stimulation frequencies >0.2 Hz. Our data indicate that impairment of NMDA receptors during early corticogenesis induces neuronal migration disorders and delays the functional maturation of the developing cortical network." 03/01/2004 - "High molecular weight microtubule-associated protein 2 over-expression in neuronal migration disorders caused by N-methyl-D-aspartate receptor activation in hamsters." 02/01/2004 - "To investigate the mechanisms of radial and tangential neuronal migration disorders, immunohistochemical expressions of reelin, vimentin, and calretinin were examined in brain lesions induced by ibotenate (an agonist of the N-methyl-D-aspartate [NMDA] complex receptor) in hamsters. "
8.	Dystroglycans (Dystroglycan)IBA 04/01/2003 - "This is thought to disrupt the link between alpha-dystroglycan and components of the extracellular matrix, and result in muscle disease and, in many cases, a neuronal-migration disorder." 11/02/2002 - "The investigators also showed that a neuronal migration disorder occurs in both the myd mouse and in a brain-restricted alpha-dystroglycan knock-out mouse that is similar to that seen in patients with MEB and FCMD. " 01/13/2004 - "Defects in O-mannosylation of alpha-dystroglycan are thought to cause certain types of congenital muscular dystrophies with neuronal migration disorders. " 11/02/2002 - "Abnormal glycosylation of alpha-dystroglycan may underlie other as yet uncharacterised forms of muscular dystrophy and neuronal migration disorders."
9.	Glutamate Receptors (Glutamate Receptor)IBA 06/01/2004 - "Upregulation of glutamate receptors in rat cerebral cortex with neuronal migration disorders." 09/01/2000 - "Neuronal migration disorder in Zellweger mice is secondary to glutamate receptor dysfunction." 02/10/2005 - "In hamsters, intrapallial injection of the glutamate receptor agonist ibotenic acid (100ng) on the day of birth (P0) induced neuronal migration disorders. "
10.	gamma-Aminobutyric Acid (GABA)IBA 04/01/2007 - "We suggest that AEDs that increase the extracellular concentration of GABA might induce severe neuronal migration disorders. " 11/16/2001 - "We analyzed the GABA(A) subunit distribution in experimentally induced subcortical heterotopia which are a subgroup of neuronal migration disorders. " 10/01/1998 - "Characterization of neuronal migration disorders in neocortical structures: quantitative receptor autoradiography of ionotropic glutamate, GABA(A) and GABA(B) receptors."

Therapies and Procedures

1.	Injections 03/01/2004 - "The cortical lesions observed after intracerebral ibotenate injections strongly resembled the following neuronal migration disorders: (1) microgyria; (2) focal subcortical heterotopia; (3) focal subependymal heterotopia; and (4) leptomeningeal glioneuronal heterotopia. " 02/01/2004 - "The cortical lesions observed after ibotenate injections had a strong resemblance to the following neuronal migration disorders: (1) microgyria, (2) focal subcortical heterotopia, and (3) leptomeningeal glioneuronal heterotopia. "
2.	Hemispherectomy 05/01/1999 - "Five of 12 children with seizures secondary to a neuronal migration disorder had reoperations, including three who ultimately underwent complete hemispherectomy. "
3.	Neurosurgical Procedures 07/01/1995 - "Application of the convulsant drug 4-aminopyridine (50 to 100 microM) induced spontaneous seizure-like discharges (duration = 76.3 +/- 46.8 sec, mean +/- SD; interval of occurrence = 225.2 +/- 87.9 sec) in slices of neocortex obtained from patients with a diagnosis of focal neuronal migration disorders during neurosurgical procedures for relief of drug-resistant seizures. "
4.	Induced Hyperthermia (Thermotherapy) 09/01/1996 - "Neuronal migration disorders increase susceptibility to hyperthermia-induced seizures in developing rats."
5.	Electrodes (Electrode) 05/01/1998 - "Intracellular recordings were obtained using biocytin-filled electrodes from 78 neurones located in both dysplastic neocortex and subcortical heterotopic aggregates in a model of neuronal migration disorder induced in rats by means of a double methylazoxymethanol injection given on embryonic day 15. "