Vascular Malformations

A spectrum of congenital, inherited, or acquired abnormalities in BLOOD VESSELS that can adversely affect the normal blood flow in ARTERIES or VEINS. Most are congenital defects such as abnormal communications between blood vessels (fistula), shunting of arterial blood directly into veins bypassing the CAPILLARIES (arteriovenous malformations), formation of large dilated blood blood-filled vessels (cavernous angioma), and swollen capillaries (capillary telangiectases). In rare cases, vascular malformations can result from trauma or diseases.

Also Known As:

Networked: 890 relevant articles (65 outcomes, 64 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Hemangioma (Angioma)
2.	Hemorrhage
3.	Neoplasms (Cancer)
4.	Port-Wine Stain (Nevus Flammeus)
5.	Pain (Aches)

Experts

1.	Fishman, Steven J: 7 articles (06/2014 - 02/2005)
2.	Redondo, Pedro: 6 articles (08/2015 - 12/2005)
3.	Mulliken, John B: 6 articles (03/2014 - 07/2005)
4.	Aguado, Leyre: 5 articles (08/2015 - 12/2010)
5.	Nagy, Janice A: 5 articles (10/2012 - 08/2006)
6.	Dvorak, Harold F: 5 articles (10/2012 - 08/2006)
7.	Burrows, Patricia E: 5 articles (12/2008 - 05/2004)
8.	Waner, Milton: 4 articles (12/2014 - 11/2006)
9.	Greene, Arin K: 4 articles (03/2014 - 03/2007)
10.	Dvorak, Ann M: 4 articles (04/2010 - 01/2005)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Vascular Malformations:

1.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 02/01/2011 - "Immunohistochemical study revealed higher level of VEGF expression in vascular malformations compared to that in normal vessels of the adjacent tissue. " 02/01/2011 - "Vascular endothelial growth factor and type 2 receptor for this factor in vascular malformations." 05/01/2010 - "Vascular endothelial growth factor concentrations in serum of patients with extensive slow-flow vascular malformations." 02/01/2008 - "The subsequent vascular malformation and rarefaction may be a function of systemic angiogenic dysregulation, with over expression of vascular endothelial growth factor but a lack of proper interactions with smooth muscle cells needed to stabilize and organize blood vessels." 07/01/2003 - "Based on these findings, we suggest that production of VEGF by vascular malformations may play a role in the neoplastic transformation of adjacent tissue."
2.	ProgesteroneFDA LinkGeneric 01/01/1993 - "The aim of our studies is to test the hypothesis that oestrogen-progesterone is an effective treatment for bleeding gastrointestinal vascular malformations in patients with a very high transfusion need and in whom surgical or endoscopic treatment failed or could not be performed. " 04/21/1990 - "The findings indicate that oestrogen-progesterone is an effective treatment for severely bleeding gastrointestinal vascular malformations." 01/01/1993 - "Oestrogen-progesterone, a new therapy of bleeding gastrointestinal vascular malformations." 04/21/1990 - "Treatment of bleeding gastrointestinal vascular malformations with oestrogen-progesterone." 10/01/1999 - "In the present study, we evaluated the efficacy of estrogen-progesterone therapy, which has been reported to control chronic bleeding in gastrointestinal vascular malformations, such as Osler-Weber Rendu disease or angiodysplasia, in GAVE-related chronic bleeding. "
3.	glucuronyl glucosamine glycan sulfate (Vessel)IBA 01/01/1996 - "It is suggested that appendages of this kind probably represent secondary vascular malformations, that they are likely to develop in reaction to abnormal hemodynamic strains upon the vessel walls, and that they might be thrombogenic and, therefore, potentially beneficial for patients with arteriovenous shunts." 01/01/2016 - "MT is subclassified as type 1 arising within a histologically normal vessel, type 2 associated with a ruptured vascular malformation, and extravascular. " 10/01/2013 - "Histologically, the mass was determined to be an intramuscular vascular malformation of the small vessel arteriovenous subtype. " 03/01/2013 - "Vascular malformations can further be subdivided by their flow characteristics and vessel type. " 02/15/2011 - "Cerebral angiography resulted normal, excluding the presence of vascular malformations or signs of vessel abnormalities. "
4.	Ethanol (Ethyl Alcohol)IBA 02/01/2014 - "Ethanol embolization of vascular malformations produces good outcomes, with control or relief of symptoms in a majority of patients." 09/01/2014 - "Anhydrous ethanol is a commonly used sclerotic agent for treating vascular malformations. " 02/01/2014 - "To retrospectively evaluate the results of endovascular therapy of vascular malformations principally treated with ethanol embolization at a single center. " 11/01/2013 - "To present our experience in treating vascular malformations in the oral cavity solely by injecting ethanol into the lesions. " 08/01/2013 - "Foot drop after ethanol embolization of calf vascular malformation: a lesson on nerve injury."
5.	bevacizumabFDA Link 01/01/2016 - "Further studies need to be conducted to confirm the efficacy of bevacizumab injections to treat vascular malformation; however, this form of management does seem promising." 11/01/2013 - "Twenty-nine patients with brain tumors or vascular malformations developed clinical and/or imaging evidence of ARE after SRS and were treated using bevacizumab. " 11/01/2008 - "Bevacizumab to treat complicated liver vascular malformations in hereditary hemorrhagic telangiectasia: a word of caution." 03/07/2012 - "In this preliminary study of patients with HHT associated with severe hepatic vascular malformations and high cardiac output, administration of bevacizumab was associated with a decrease in cardiac output and reduced duration and number of episodes of epistaxis. " 07/01/2013 - "Bevacizumab: finding its niche in the treatment of heart failure secondary to liver vascular malformations in hereditary hemorrhagic telangiectasia."
6.	polidocanol (Laureth)FDA Link 01/01/2014 - "We have reviewed our experience (15 patients during the period 2008-2012) in the treatment of low flow vascular malformations (LFVMs) of the face and oral cavity with polidocanol foam sclerotherapy. " 03/01/2011 - "Treatment of low-flow vascular malformations by ultrasound-guided sclerotherapy with polidocanol foam: 24 cases and literature review." 09/01/2002 - "The aim of this prospective study was to assess the safety and efficacy of sonographically guided percutaneous injection of 1% polidocanol for sclerosis of peripheral vascular malformations. " 03/01/2011 - "This study reports our experience in treating low-flow vascular malformations by ultrasound-guided sclerosis with polidocanol foam at the Vascular Medicine Department in Grenoble, France. " 07/01/2015 - "We describe in detail a patient who received treatment with ultrasound-guided laser interruption of feeding vessels combined with polidocanol sclerotherapy after the recurrence of forearm high-flow vascular malformation. "
7.	Adrenal Cortex Hormones (Corticosteroids)IBA 04/01/1998 - "To evaluate the efficacy of interstitial Nd:YAG photocoagulation as an adjunct to intralesional and systemic corticosteroids for treatment of hemangiomas and vascular malformations that had failed to respond to other therapies. " 12/01/2001 - "Corticosteroids are widely used in patients with raised intracranial pressure associated with cerebral neoplasms, cerebral vascular malformations, cerebral ischaemia and benign intracranial hypertension. " 07/01/2005 - "The majority of vascular anomalies can be diagnosed accurately based on natural history and physical examination; however, there is no convenient, noninvasive, and objective method to (1) differentiate hemangioma from vascular malformation; (2) determine whether a hemangioma is in the proliferating or involuting phase; (3) tell whether or not corticosteroids or interferon alfa-2a is effective for hemangioma; or (4) follow up hemangioma. "
8.	Melanins (Melanin)IBA 01/01/1997 - "Epidermal melanin is a limiting factor for obtaining beneficial results in dermatological treatment of vascular malformations. " 01/01/1995 - "Melanin is a limiting factor for obtaining beneficial results in dermatological treatment of vascular malformations. "
9.	Doxycycline (Vibramycin)FDA LinkGeneric 12/01/2007 - "Endoscopic injection sclerotherapy with doxycycline for lymphatic and low-flow vascular malformations in the GI tract is feasible, easy, safe, and effective." 12/01/2007 - "To evaluate the feasibility and efficacy of endoscopic injection sclerotherapy with doxycycline for low-flow vascular malformations in the GI tract. " 03/01/2015 - "Intramuscular vascular malformations: a rare cause of exertional leg pain and a novel treatment approach with ultrasound-guided doxycycline sclerotherapy."
10.	Thalidomide (Thalomid)FDA Link 05/01/2012 - "[The potential pathogenesis of gastrointestinal vascular malformation and the potential mechanism of thalidomide in the treatment of gastrointestinal vascular malformation]." 11/01/2011 - "Thalidomide is an effective and relatively safe treatment for patients with refractory bleeding from gastrointestinal vascular malformations. " 11/01/2011 - "Efficacy of thalidomide for refractory gastrointestinal bleeding from vascular malformation." 05/01/2012 - "To study the pathogenesis of gastrointestinal vascular malformation (GIVM) and the potential mechanism of thalidomide in the treatment of gastrointestinal bleeding due to GIVM. " 11/01/2011 - "We investigated the long-term efficacy and safety of thalidomide for refractory bleeding from gastrointestinal vascular malformations in an open-label, randomized study. "

Therapies and Procedures

1.	Sclerotherapy 11/01/2012 - "Treatment with 3% STD sclerotherapy is effective in venous and some lymphatic vascular malformations. " 06/01/2011 - "Sclerotherapy was effective in the treatment of vascular malformations, and the method chosen was adequate for lesion resolution without complications." 01/01/2009 - "Sclerotherapy is effective in the treatment of vascular malformations. " 02/01/2014 - "Sclerotherapy is a safe and effective treatment for head and neck vascular malformations in children. " 07/01/2012 - "Sclerotherapy is useful for the treatment of arteriovenous vascular malformations. "
2.	Lasers (Laser) 01/01/2005 - "The aim of the study was to present a prospective analysis of the efficacy of treatment of PWS vascular malformations by means of KTP 532 nm laser. " 01/01/2000 - "The study was to determine the efficacy of the flashlamp-pumped dye (FLPD) laser in the treatment of vascular malformations in African-American patients. " 07/01/2006 - "Modern lasers allow different parameters to be altered in an effort to gain further improvement in otherwise resistant capillary vascular malformations (CMs). " 01/01/2014 - "In last few years, thanks to laser technology with minimally invasive approach, there was a growing need for treatment of oral vascular malformations inside the dental offices. " 02/01/2013 - "The authors conclude that ultrasound-guided ILP with a laser is a promising technique for less-invasive treatment of a vascular malformation in the oral cavity."
3.	Dye Lasers 01/01/2013 - "The pulsed dye laser (PDL) is recognized both as an effective treatment for vascular malformations and the as first treatment of choice for these lesions. " 04/01/1996 - "Treatment with the 585 nm flashlamp pulsed dye laser is safe and effective in the management of superficial vascular malformations. " 01/01/2013 - "Histological study on the treatment of vascular malformations resistant to pulsed dye laser." 04/01/2015 - "Currently, there are no standardized, objective, and clinically applicable methods to predict the outcome of pulsed dye laser (PDL) therapy on capillary vascular malformation (CVM) patients. " 11/01/2013 - "To use our assessment tool to analyze results from pulsed-dye laser therapy used for pediatric facial vascular malformations, and to determine interrater reliability of our assessment tool in a standard clinical environment without the use of professional photography. "
4.	Solid-State Lasers 02/01/2014 - "These results suggest that the Nd:YAG laser is effective for the treatment of vascular malformations in the oral region." 01/01/1999 - "The Nd:YAG-laser radiation at 1064 nm presents an effective treatment of vascular malformations due to its deep penetration into the tissue. " 11/01/2015 - "Fifteen patients diagnosed with oral vascular malformations were treated with Nd:YAG laser followed by three sessions of biostimulation. " 03/01/2013 - "One patient was treated electively with the Nd:YAG laser owing to a vascular malformation. " 10/01/2012 - "Vascular malformation of the glans penis successfully treated with Nd:YAG laser."
5.	Light Coagulation 11/01/2012 - "Ultrasound-guided intralesional photocoagulation of intramuscular vascular malformation in the masseter muscle." 11/01/1991 - "Nd-YAG laser photocoagulation has proved safe and effective for treatment of low-flow vascular malformations of the head and neck." 02/01/2014 - "The purpose of this study is to make a clinical evaluation of vascular malformations in the oral region treated by photocoagulation with an Nd:YAG laser, to determine its effectiveness. " 11/01/2015 - "The aim of the present paper was to report a case series of oral vascular malformations treated with Nd:YAG laser photocoagulation, highlighting the clinical evolution and post-surgical complications. " 02/01/2014 - "The subjects were 67 patients (69 cases) with vascular malformations in the oral region who visited our hospital from 2004 to 2011, and were treated by photocoagulation using an Nd:YAG laser. "