Large Granular Lymphocytic Leukemia

A spectrum of disorders characterized by clonal expansions of the peripheral blood LYMPHOCYTE populations known as large granular lymphocytes which contain abundant cytoplasm and azurophilic granules. Subtypes develop from either CD3-negative NATURAL KILLER CELLS or CD3-positive T-CELLS. The clinical course of both subtypes can vary from spontaneous regression to progressive, malignant disease.
Also Known As:
Leukemia, Large Granular Lymphocytic; LGL Leukemia; Large Granular Lymphocyte Leukemia; Leukemia, LGL; Leukemia, NK-LGL; Leukemia, T-LGL; Lymphoproliferative Disease of Granular Lymphocytes; Lymphoproliferative Disease of Large Granular Lymphocytes; NK-Cell Large Granular Lymphocytic Leukemia; NK-LGL Leukemia; T-Cell Large Granular Lymphocyte Leukemia; T-LGL Leukemia; LGL Leukemias; Leukemia, NK LGL; Leukemia, T Cell Large Granular Lymphocytic; Leukemia, T LGL; Leukemias, LGL; Leukemias, NK-LGL; Leukemias, T-LGL; NK Cell Large Granular Lymphocytic Leukemia; NK LGL Leukemia; NK-LGL Leukemias; T Cell Large Granular Lymphocyte Leukemia; T Cell Large Granular Lymphocytic Leukemia; T LGL Leukemia; T-LGL Leukemias; Leukemia, Lymphocytic, Large Granular; Leukemia, Natural Killer Cell Large Granular Lymphocytic; Leukemia, T-Cell Large Granular Lymphocytic; Natural Killer Cell Large Granular Lymphocytic Leukemia; T-Cell Large Granular Lymphocytic Leukemia
Networked: 227 relevant articles (16 outcomes, 18 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Neoplasms (Cancer)
2. Rare Diseases (Rare Disease)
3. Pure Red-Cell Aplasia
4. Infection
5. Rheumatoid Arthritis


1. Loughran, Thomas P: 33 articles (03/2015 - 12/2002)
2. Maciejewski, Jaroslaw P: 11 articles (12/2013 - 10/2005)
3. Epling-Burnette, P K: 9 articles (04/2011 - 05/2000)
4. Sokol, Lubomir: 8 articles (10/2013 - 08/2003)
5. Liu, Xin: 7 articles (12/2013 - 08/2008)
6. Lamy, Thierry: 6 articles (04/2014 - 07/2003)
7. Clemente, Michael J: 6 articles (12/2013 - 10/2009)
8. Kothapalli, Ravi: 6 articles (08/2008 - 12/2002)
9. Loughran, T P: 5 articles (04/2015 - 05/2000)
10. Zambello, Renato: 5 articles (12/2014 - 03/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Large Granular Lymphocytic Leukemia:
1. alemtuzumab (Campath)FDA Link
2. Cyclosporine (Ciclosporin)FDA LinkGeneric
3. fludarabineIBA
4. AntibodiesIBA
5. AntigensIBA
6. Methotrexate (Mexate)FDA LinkGeneric
7. Sirolimus (Rapamycin)FDA Link
8. T-Cell Antigen Receptors (T-Cell Receptor)IBA
9. Mitoxantrone (Novantrone)FDA LinkGeneric
10. Dexamethasone (Maxidex)FDA LinkGeneric

Therapies and Procedures

1. Splenectomy
2. Photopheresis
3. Therapeutics
4. Kidney Transplantation
5. Intravenous Infusions