Immune Reconstitution Inflammatory Syndrome

Exuberant inflammatory response towards previously undiagnosed or incubating opportunistic pathogens. It is frequently seen in AIDS patients following HAART.
Also Known As:
Immune Reconstitution Syndrome; Disease, Immune Reconstitution; Immune Reconstitution Syndromes; Reconstitution Disease, Immune; Reconstitution Syndrome, Immune; Reconstitution Syndromes, Immune; Restoration Syndrome, Immune; Syndrome, Immune Reconstitution; Syndrome, Immune Restoration; Syndromes, Immune Reconstitution; Immune Reconstitution Disease; Immune Restoration Syndrome
Networked: 547 relevant articles (9 outcomes, 23 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Kaposi Sarcoma (Kaposi's Sarcoma)
2. Disease Progression
3. Acquired Immunodeficiency Syndrome (AIDS)
4. Progressive Multifocal Leukoencephalopathy
5. HIV Infections (HIV Infection)


1. Meintjes, Graeme: 23 articles (01/2015 - 10/2006)
2. Wilkinson, Robert J: 17 articles (01/2015 - 11/2007)
3. Colebunders, Robert: 13 articles (01/2015 - 08/2008)
4. Sereti, Irini: 11 articles (02/2015 - 01/2010)
5. French, Martyn A: 11 articles (02/2015 - 08/2008)
6. Maartens, Gary: 10 articles (01/2015 - 08/2008)
7. Singh, Nina: 10 articles (01/2015 - 06/2005)
8. Lortholary, Olivier: 10 articles (01/2015 - 06/2005)
9. Swaminathan, Soumya: 9 articles (02/2015 - 07/2006)
10. Pepper, Dominique J: 9 articles (02/2013 - 11/2007)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Immune Reconstitution Inflammatory Syndrome:
1. AnthracyclinesIBA
2. Paclitaxel (Taxol)FDA LinkGeneric
3. pegylated liposomal doxorubicinIBA
4. Biological Markers (Surrogate Marker)IBA
5. maravirocFDA Link
6. Thalidomide (Thalomid)FDA Link
7. Azithromycin (Zithromax)FDA LinkGeneric
8. liposomal amphotericin BFDA Link
9. natalizumab (Tysabri)FDA Link
10. Carbon MonoxideIBA

Therapies and Procedures

1. Highly Active Antiretroviral Therapy (HAART)
2. Drug Therapy (Chemotherapy)
11/01/2014 - "Immune reconstitution syndrome and APB after high dose chemotherapy following PBSCT are discussed herein. "
08/01/2006 - "We considered that, in this case, disseminated tuberculosis and firstly administered steroid that might suppress immune function, and discontinuation of steroid therapy followed by the bactericidal antituberculous chemotherapy were associated with the development of the paradoxical reactions, by analogy with immune reconstitution syndrome frequently reported in HIV-related tuberculosis patients."
01/01/2015 - "[Severe inflammation during recovery from neutropenia: the immune reconstitution inflammatory syndrome following chemotherapy]."
01/01/2013 - "This 2 part review emphasizes a practical consultative approach to central and peripheral nervous system problems related to HCT or SOT with clinical and neuroimaging examples from the authors' institutional experience with the following conditions: the diversity of manifestations of common infections such as varicella zoster virus, Aspergillus, and progressive multifocal leukoencephalopathy (PML), drug therapy-related complications, stroke mechanisms, the spectrum of graft versus host disease (GVHD), and neurologically important syndromes of immune reconstitution inflammatory syndrome (IRIS), posterior reversible encephalopathy syndrome (PRES), and posttransplantation lymphoproliferative disorder (PTLD). "
11/01/2007 - "Combining drug therapies for dual infection by Mycobacterium tuberculosis and HIV-1 is made complex by high pill burdens, shared drug toxicities, drug-drug and drug-disease interactions, immune reconstitution inflammatory syndrome, co-morbid diseases and drug resistance in both bacillus and virus. "
3. Art Therapy
4. Transplantation (Transplant Recipients)
5. Plasma Exchange