Microsatellite Instability

The occurrence of highly polymorphic mono- and dinucleotide MICROSATELLITE REPEATS in somatic cells. It is a form of genome instability associated with defects in DNA MISMATCH REPAIR.
Also Known As:
Replication Error Phenotype; Error Phenotype, Replication; Error Phenotypes, Replication; Instability, Microsatellite; Phenotype, Replication Error; Phenotypes, Replication Error; Replication Error Phenotypes
Networked: 3512 relevant articles (40 outcomes, 331 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Colorectal Neoplasms (Colorectal Cancer)
2. Neoplasms (Cancer)
3. Colonic Neoplasms (Colon Cancer)
4. Hereditary Nonpolyposis Colorectal Neoplasms (Hereditary Nonpolyposis Colorectal Cancer)
5. Carcinoma (Carcinomatosis)


1. Ogino, Shuji: 68 articles (09/2015 - 01/2006)
2. Fuchs, Charles S: 64 articles (09/2015 - 01/2006)
3. Nosho, Katsuhiko: 47 articles (09/2015 - 05/2005)
4. Thibodeau, Stephen N: 43 articles (10/2015 - 02/2002)
5. Boland, C Richard: 37 articles (06/2015 - 07/2002)
6. Goel, Ajay: 37 articles (05/2015 - 01/2003)
7. Shima, Kaori: 34 articles (07/2013 - 01/2008)
8. Lee, Sug Hyung: 30 articles (11/2015 - 12/2006)
9. Yoo, Nam Jin: 30 articles (11/2015 - 12/2006)
10. Baba, Yoshifumi: 30 articles (09/2015 - 01/2009)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Microsatellite Instability:
1. N-methylsuccinimideIBA
2. Fluorouracil (Carac)FDA LinkGeneric
3. DNA (Deoxyribonucleic Acid)IBA
4. Calcibiotic Root Canal SealerIBA
5. Thymidylate SynthaseIBA
6. irinotecan (Camptosar)FDA LinkGeneric
7. Leucovorin (Folinic Acid)FDA Link
8. Proteins (Proteins, Gene)IBA
9. Aspirin (Acetylsalicylic Acid)FDA LinkGeneric
10. AntigensIBA

Therapies and Procedures

1. Adjuvant Chemotherapy
2. Drug Therapy (Chemotherapy)
3. Transplantation (Transplant Recipients)
4. Colectomy
01/01/2014 - "Metachronous serrated neoplasia is uncommon after right colectomy in patients with methylator colon cancers with a high degree of microsatellite instability."
06/01/1999 - "Sites of cancer, dysplasia, and nondysplasia from 14 UC colectomy cases containing cancer were analyzed for chromosomal alterations by comparative genomic hybridization (CGH) and for microsatellite instability using a series of 10 microsatellite markers. "
09/01/2004 - "A subtotal colectomy was performed and the subsequent microsatellite instability (MSI) analysis revealed high MSI in the resected tumor tissue. "
07/20/2000 - "To search for a genetic basis for this predisposition, we studied the incidence of microsatellite instability (MSI) in paraffin-embedded colectomy specimens of 124 young (<50 years old) Chinese colorectal cancer patients referred to the Hong Kong Hereditary Gastrointestinal Cancer Registry from 1995 to 1998. "
12/01/2004 - "The clinical research advances included the efficacy of infliximab in the treatment of fistulizing Crohn's disease, survival after isolated intestinal transplantation, the role of endoscopic treatment of bleeding peptic ulcers and Barrett's esophagus, the recurrence of cancer after laparoscopic colectomy, the impact of microsatellite instability on the response to adjuvant chemotherapy with 5-fluorouracil (5-FU), the epidemiology of obesity and its response to low-carbohydrate diets, the potential role of gastrointestinal factors in the development of obesity, and, the newly appreciated condition, autoimmune pancreatitis with associated cholangitis. "
5. Neoadjuvant Therapy