Chymases (Chymase)

A family of neutral serine proteases with CHYMOTRYPSIN-like activity. Chymases are primarily found in the SECRETORY GRANULES of MAST CELLS and are released during mast cell degranulation.

Also Known As:

Networked: 533 relevant articles (20 outcomes, 92 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Takai, Shinji: 57 articles (08/2014 - 02/2002)
2.	Miyazaki, Mizuo: 51 articles (08/2014 - 02/2002)
3.	Jin, Denan: 33 articles (08/2014 - 02/2002)
4.	Muramatsu, Michiko: 19 articles (06/2009 - 09/2002)
5.	Urata, Hidenori: 14 articles (12/2015 - 09/2002)
6.	Pejler, Gunnar: 11 articles (02/2014 - 03/2009)
7.	Fukuda, Yoshiaki: 11 articles (10/2011 - 02/2002)
8.	Takai, S: 10 articles (01/2013 - 07/2000)
9.	Tomimori, Yoshiaki: 10 articles (10/2011 - 02/2002)
10.	Sakaguchi, Masato: 10 articles (04/2005 - 05/2002)

Related Diseases

1.	Myocardial Infarction 05/01/2004 - "We recently found that cardiac chymase was activated significantly and survival rate markedly improved by treatment with chymase inhibitors after myocardial infarction (MI) in hamsters. " 04/01/2010 - "We found that combined chymase and ACE inhibition, relative to ACE inhibition alone, improved LV function, decreased adverse cardiac remodeling, and improved survival after myocardial infarction in hamsters. " 01/01/2010 - "Cardiac dysfunction after myocardial infarction was also attenuated by chymase inhibition. " 08/01/2004 - "For example, cardiac chymase was activated earlier than ACE and this activation lasted longer than that of ACE after myocardial infarction (MI) in hamsters. " 05/01/2004 - "An antiarrhythmic effect of a chymase inhibitor after myocardial infarction."
2.	Heart Failure 04/01/2010 - "These results suggest that chymase inhibitors could be a useful addition to ACE inhibitor therapy in the treatment of heart failure." 08/01/2008 - "In the group of heart failure patients, the odds ratio of chymase-1 GG genotype having a nonischemic etiology was 2.48 (95% CI 1.23-5.00). " 08/01/2008 - "The chymase-1 -1903 GG genotype was associated with a nonischemic heart failure etiology (chi = 6.67, P = 0.009). " 11/20/2005 - "A dual Ang II forming pathway from both ACE and chymase in the hamster hearts plays an important role during the development of heart failure. " 09/28/1999 - "Mast cells cause apoptosis of cardiomyocytes and proliferation of other intramyocardial cells via the activity of RMCP 1. Our results suggest that mast cell chymase may play a role in the progression of heart failure, because loss of cardiomyocytes and proliferation of nonmyocardial cells exaggerate its pathophysiology."
3.	Atopic Dermatitis (Atopic Eczema) 11/01/2002 - "Therapeutic potential of a specific chymase inhibitor in atopic dermatitis." 01/01/2001 - "Absence of association between a variant of the mast cell chymase gene and atopic dermatitis in an Italian population." 06/01/1999 - "Association between mast cell chymase genotype and atopic eczema: comparison between patients with atopic eczema alone and those with atopic eczema and atopic respiratory disease." 09/01/1998 - "No evidence for an association between a variant of the mast cell chymase gene and atopic dermatitis based on case-control and haplotype-relative-risk analyses." 04/01/2005 - "In this study we sought to determine the role of mast cell chymase in atopic dermatitis (AD) in comparison with its role in psoriasis and normal skin. "
4.	Fibrosis (Cirrhosis) 08/20/2012 - "Chymase inhibition prevents myocardial fibrosis through the attenuation of NOX4-associated oxidative stress in diabetic hamsters." 08/01/2012 - "The results indicate an important role for chymase in inducing fibrosis through TGF-β1 activation, parallel with Ang II effects." 08/01/2012 - "Similar to HG-stimulated RMCs, control RMCs treated with chymase responded with increased expression of TGF-β1, Smad 3 and fibrosis markers. " 08/01/2012 - "RMCs exposed to HG presented increases in chymase activity and expression, together with upregulation in fibrosis markers and in the TGF-β1 signaling pathway. " 10/01/2011 - "It may also attenuate fibrosis induced by activated chymase after AMI-R."
5.	Inflammation 10/01/2012 - "Such studies, to date, with respect to IBD at least, are descriptive in the clinical context; nonetheless, preclinical studies implicate chymase in the pathogenesis of gut inflammation. " 11/15/2009 - "However, in this study, we show that one of the substances stored within MC granule, chymase, in fact has a protective role in allergic airway inflammation, indicating that MCs may possess both harmful and protective activities in connection with this type of disease. " 04/01/2005 - "Recent studies have demonstrated that chymase inhibitors inhibit skin inflammation. " 03/27/2015 - "Since chymase is released from cardiac mast cells during stress (e.g., volume/pressure overload, inflammation), we hypothesized that GPR30-related cardioprotection after E2 loss might occur through its opposing actions on cardiac mast cell proliferation and chymase production. " 01/03/2014 - "Here we explored the contribution of MCPT4 and human chymase to the control of danger-induced inflammation. "

Related Drugs and Biologics

1.	Angiotensin II
2.	Tryptases (Tryptase)
3.	Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)
4.	6- (5- chloro- 2- methoxybenzyl)- 4- alarkylaminocarbonyl- 1,4- diazepane- 2,5- dione
5.	NK3201
6.	Cathepsin G
7.	Transforming Growth Factor beta (TGF-beta)
8.	TY 51469
9.	Proto-Oncogene Proteins c-kit (Proto-Oncogene Protein c-kit)
10.	Trichloroacetic Acid

Related Therapies and Procedures

1.	Surgical Instruments (Clip)
2.	Renal Dialysis (Hemodialysis)
3.	Catheters
4.	Angioplasty (Angioplasty, Transluminal)
5.	Oral Administration