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Tryptases (Tryptase)

A family of neutral serine proteases with TRYPSIN-like activity. Tryptases are primarily found in the SECRETORY GRANULES of MAST CELLS and are released during mast cell degranulation.

Also Known As:

Tryptase; Mast Cell Tryptase; Skin Tryptase; alpha-Tryptase; alpha-Tryptases; beta-Tryptase; delta-Tryptase; delta-Tryptases; gamma-Tryptase; gamma-Tryptases; Tryptase, Skin; alpha Tryptase; alpha Tryptases; beta Tryptase; beta Tryptases; delta Tryptase; delta Tryptases; gamma Tryptase; gamma Tryptases; beta-Tryptases

Networked: 1357 relevant articles (29 outcomes, 168 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Valent, Peter: 20 articles (01/2015 - 06/2002)
2.	Schwartz, Lawrence B: 19 articles (03/2015 - 01/2002)
3.	Ranieri, Girolamo: 15 articles (10/2015 - 07/2009)
4.	Valent, P: 15 articles (10/2014 - 05/2000)
5.	Sperr, Wolfgang R: 14 articles (01/2015 - 06/2002)
6.	Stevens, Richard L: 13 articles (06/2014 - 06/2007)
7.	Metcalfe, Dean D: 12 articles (12/2015 - 01/2002)
8.	Ammendola, Michele: 12 articles (10/2015 - 07/2009)
9.	Horny, Hans-Peter: 12 articles (09/2015 - 06/2002)
10.	Akin, Cem: 12 articles (10/2014 - 01/2002)

Related Diseases

1.	Anaphylaxis (Anaphylactic Shock) 06/01/2006 - "Thus pro- and mature beta tryptase measurements are useful but associated with false-negative and false-positive results, which need to be considered in drawing clinical conclusions in cases of suspected anaphylaxis." 06/01/2008 - "The gold standard was the results of drug challenges and serum tryptase in cases of anaphylaxis. " 11/01/1997 - "We conclude that serum tryptase determinations are helpful in the diagnosis of anaphylactic shock and anaphylaxis, but serial measurements may be needed to confirm mast-cell participation in milder reactions." 07/01/2014 - "This study investigates the utility of serum tryptase for the confirmation of shrimp-induced anaphylaxis. " 01/01/2013 - "It was the aim of this study to determine sequential serum tryptase concentrations during anaphylaxis and to evaluate its potential as a diagnostic marker. "
2.	Hypersensitivity (Allergy) 01/01/2012 - "The objective of this study was to measure tryptase levels in subjects with respiratory allergy and analyze the results in the light of tolerance/intolerance to injection SIT. " 07/01/2010 - "To study the role of the serum tryptase as a diagnostic parameter for individual risk evaluation and its impact on the severity of allergic reactions in elderly people. " 07/01/2000 - "The clinical utility of beta-tryptase determinations in the evaluation of acute allergic reactions needs further study." 09/01/2015 - "Our results collectively suggest that tryptase and PAR2 are involved in OVA allergy-induced scratching behavior. " 03/01/2015 - "Presence or absence of elevated acute total serum tryptase by itself is not a definitive marker for an allergic reaction."
3.	Mastocytosis (Mast-Cell Disease) 04/01/2014 - "We highlight a recent study on IL-31 in mastocytosis, which reports on elevated serum levels of IL-31 in adults correlating with the severity of disease categories, tryptase levels and percentage of bone marrow infiltration. " 06/01/2002 - "In the present study, serum tryptase levels were measured in patients with mastocytosis by fluoroenzyme immunoassay and compared with the extent of infiltration of the bone marrow (BM) by neoplastic MC, determined by tryptase immunohistochemistry. " 01/01/2016 - "A normal value of tryptase (≤11.4 ng/ml) in these patients does not exclude a diagnosis of mastocytosis. " 12/01/2015 - "We sought to examine clinical aspects of pediatric mastocytosis in relationship to serum tryptase levels and bone marrow pathology to provide practical guidance for management. " 12/01/2015 - "Assessment of clinical findings, tryptase levels, and bone marrow histopathology in the management of pediatric mastocytosis."
4.	Atopic Dermatitis (Atopic Eczema) 08/01/2006 - "Oral antihistamine therapy influences plasma tryptase levels in adult atopic dermatitis." 07/16/2003 - "The endogenous PAR-2 agonist tryptase was increased up to fourfold in atopic dermatitis (AD) patients. " 02/01/2007 - "This observation was seen in only psoriatic lesions, even in almost cured lesions, while in atopic dermatitis or chronic eczema only mast cells doubly positive for bikunin and tryptase were seen. " 04/01/2009 - "Serum mast cell tryptase is not a useful marker for disease severity in psoriasis or atopic dermatitis." 09/01/2015 - "The aim of the current study was to investigate the involvement of tryptase and protease-activated receptor-2 (PAR2) in the pathogenesis of itch using a recently developed murine model of atopic dermatitis (AD) elicited by epicutaneous sensitization with ovalbumin (OVA). "
5.	Food Hypersensitivity (Food Allergy) 01/01/2013 - "The objective of this study was to investigate whether mast cell tryptase (T), a typical mast cell-associated marker, may help to detect patients with food allergy. " 01/01/2011 - "Our aim was to examine whether measurement of the saliva mast cell tryptase (MCT) concentrations before and after a mucosal challenge test with the offending food would be helpful in diagnosing food allergy. " 01/01/2007 - "However, several factors, including food exposure, may account for the increase in fecal tryptase and further studies are necessary to elucidate the role of mast cells in food hypersensitivity." 01/01/2007 - "The aim of this study was to explore whether locally released tryptase could be detected in stool samples from patients with food hypersensitivity. " 01/01/2013 - "Mast cell tryptase levels in gut mucosa in patients with gastrointestinal symptoms caused by food allergy."

Related Drugs and Biologics

1.	Venoms
2.	Chymases (Chymase)
3.	Histamine (Histamine Dihydrochloride)
4.	Tryptases (Tryptase)
5.	Eosinophil-Derived Neurotoxin
6.	Immunoglobulin E (IgE)
7.	Eosinophil Cationic Protein
8.	Peroxidase (Myeloperoxidase)
9.	Cetirizine (Zyrtec)
10.	Interleukin-2 (IL2)

Related Therapies and Procedures

1.	Immunotherapy
2.	Anesthesia
3.	Renal Dialysis (Hemodialysis)
4.	Gastrectomy
5.	Activities of Daily Living (ADL)