Nanocapsules

Nanometer-sized, hollow, spherically-shaped objects that can be utilized to encapsulate small amounts of pharmaceuticals, enzymes, or other catalysts (Glossary of Biotechnology and Nanobiotechnology, 4th ed).

Also Known As:

Networked: 862 relevant articles (93 outcomes, 152 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Pohlmann, Adriana R: 29 articles (01/2018 - 05/2008)
2.	Benoit, Jean-Pierre: 28 articles (08/2022 - 12/2007)
3.	Passirani, Catherine: 25 articles (08/2022 - 09/2008)
4.	Pohlmann, Adriana Raffin: 22 articles (12/2021 - 02/2013)
5.	Cruz, Letícia: 21 articles (12/2022 - 12/2013)
6.	Guterres, Silvia S: 18 articles (12/2020 - 12/2010)
7.	Guterres, Sílvia Stanisçuaski: 13 articles (12/2021 - 02/2013)
8.	Bernardi, Andressa: 13 articles (05/2021 - 05/2008)
9.	Mosqueira, Vanessa Carla Furtado: 12 articles (01/2022 - 02/2008)
10.	Beck, Ruy Carlos Ruver: 12 articles (06/2020 - 02/2013)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2023 - "In addition, the in vivo tumor accumulation of HSA/CAT@Ce6 nanocapsules is significantly larger than that of rigid nanoparticles and Ce6, meaning they are highly effective in tumor cell ablation. " 03/07/2015 - "The results show that the bio SiO2 nanocapsules synthesized with CPMV present an effective cargo and are suitable for nanoformulating with DOX, with the resultant nanoformulation showing good promise for killing cancer specific cells." 02/21/2017 - "This strategy is effective for inhibiting growth and inducing death in several types of xenograft tumors, and the nanocapsule elicits no safety concerns in animals. " 05/01/2015 - "Hence, we conclude that this magnetic field assisted nanocapsule system can be used for delivery of chemotherapeutics for potential therapeutic efficacy at minimal dose in multidrug resistant cancers. " 01/01/2015 - "In vivo anticancer activity of GEM-loaded PEG-AcPLA nanocapsules using two xenograft murine models of human solid tumors further supported the efficacy of this nano-drug, thus providing preliminary results about the potential clinical application of this innovative nanotherapeutic."
2.	Breast Neoplasms (Breast Cancer) 01/01/2020 - "The study's aim is to design novel PEGylated-PLGA polymeric nanocapsules (NCs) for HK delivery to breast tumor-bearing mice after systemic administration. " 04/01/2015 - "In vitro studies of the prepared nanocapsules were conducted in MDA-MB-231 breast cancer cells. " 11/11/2022 - "MTT and flow cytometry analysis showed that a synergistic anti-proliferation and promoting apoptosis effect was achieved when the nanocapsules were added into breast cancer cell lines. " 02/01/2022 - "Moreover, the nanocapsules displayed active targeting and selectivity to metastatic breast cancer cells. " 01/01/2022 - "Further, the mitochondrial membrane potential and apoptosis assay were performed to analyze the therapeutic significance of these nanocapsules to kill breast cancer. "
3.	Glioblastoma (Glioblastoma Multiforme) 01/01/2022 - "Blood-brain barrier-penetrating single CRISPR-Cas9 nanocapsules for effective and safe glioblastoma gene therapy." 01/01/2017 - "Characterization of the distribution, retention, and efficacy of internal radiation of 188Re-lipid nanocapsules in an immunocompromised human glioblastoma model." 03/01/2023 - "Cascade-Responsive 2-DG Nanocapsules Encapsulate aV-siCPT1C Conjugates to Inhibit Glioblastoma through Multiple Inhibition of Energy Metabolism." 01/07/2019 - "The developed DIM-loaded nanocapsules were further evaluated regarding the in vitro release profile and cytotoxicity against a human glioblastoma cell line (U87 cells). " 01/01/2022 - "We designed a unique nanocapsule for efficient single CRISPR-Cas9 capsuling, noninvasive brain delivery and tumor cell targeting, demonstrating an effective and safe strategy for glioblastoma gene therapy. "
4.	Melanoma (Melanoma, Malignant) 08/29/2023 - "Incorporating DIM into nanocapsules increased its antitumor potential against human melanoma cells (A-375) (IC50 > 24.00 µg/mL free DIM × 2.89 µg/mL nanocapsules). " 01/01/2022 - "We report the synthesis of plasmonic nanocapsules and the cellular responses they induce in 3D melanoma models for their perspective use as a photothermal therapeutic agent. " 01/01/2022 - "Multiphoton imaging of melanoma 3D models with plasmonic nanocapsules." 01/01/2022 - "The aim of this work was to investigate the in vitro cytotoxic effect of previously developed nanocapsules, nanoemulsion, and microemulsion based on bullfrog oil (BFO) against human melanoma cells (A2058). " 12/01/2015 - "Moreover, we evaluated the effects of these new nanocapsules on a three-dimensional human reconstructed model of skin melanoma. "
5.	Glioma (Gliomas) 01/01/2013 - "The hybrid bio-nanocapsules were effective for delivering 7-propionyltaxol 2″-O-α-D-glucoside to human brain glioma cells. " 01/01/2022 - "Glioma-derived exosomes hijack the blood-brain barrier to facilitate nanocapsule delivery via LCN2." 08/01/2014 - "The results demonstrate that the dual (Dox+Cur)-drug-loaded nanocapsule can be effectively delivered into RG2 glioma cells to enhance the cytotoxicity against the cells through a synergistic effect. " 08/01/2014 - "Magnetic core-shell nanocapsules with dual-targeting capabilities and co-delivery of multiple drugs to treat brain gliomas." 04/01/2013 - "Finally, when such nanocapsules were injected in mice bearing a glioma tumour, they are preferentially targeted to the tumour and reduce its progression. "

Related Drugs and Biologics

1.	Lipids
2.	Curcumin
3.	Chitosan
4.	caprolactone
5.	Paclitaxel (Taxol)
6.	Docetaxel (Taxotere)
7.	Enzymes
8.	Cisplatin (Platino)
9.	Resveratrol
10.	Peptides (Polypeptides)

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Intravenous Administration
4.	Lasers (Laser)
5.	Immunotherapy