Interleukin-23 (Interleukin 23)

A heterodimeric cytokine that plays a role in innate and adaptive immune responses. Interleukin-23 is comprised of a unique 19 kDa subunit and 40 kDa subunit that is shared with INTERLEUKIN-12. It is produced by DENDRITIC CELLS; MACROPHAGES and a variety of other immune cells

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Networked: 1162 relevant articles (51 outcomes, 165 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Cua, Daniel J: 23 articles (01/2014 - 02/2003)
2.	Kastelein, Robert A: 23 articles (07/2012 - 02/2003)
3.	Iwakura, Yoichiro: 20 articles (10/2013 - 04/2004)
4.	Krueger, James G: 12 articles (11/2015 - 01/2004)
5.	Powrie, Fiona: 12 articles (07/2015 - 08/2006)
6.	Kolls, Jay K: 11 articles (10/2015 - 05/2003)
7.	Yoshimura, Akihiko: 10 articles (09/2015 - 08/2009)
8.	Bowman, Edward P: 10 articles (05/2015 - 06/2006)
9.	Rostami, Abdolmohamad: 10 articles (06/2011 - 02/2003)
10.	Zhang, Guang-Xian: 10 articles (06/2011 - 02/2003)

Related Diseases

1.	Psoriasis (Pustulosis Palmaris et Plantaris) 07/01/2015 - "BI 655066 was well tolerated and associated with rapid, substantial, and durable clinical improvement in patients with moderate-to-severe psoriasis, supporting a central role for IL-23 in psoriasis pathogenesis." 05/14/2015 - "Evidence suggests that specific inhibition of IL-23 would result in improvement in psoriasis. " 05/14/2015 - "Clinical improvement in psoriasis with specific targeting of interleukin-23." 09/01/2007 - "Sequence variants in the genes for the interleukin-23 receptor (IL23R) and its ligand (IL12B) confer protection against psoriasis." 10/01/2015 - "The results of the phase II trials support IL-23 as an essential target in psoriasis treatment. "
2.	Infection 12/15/2009 - "IL-23 is required for protection against systemic infection with Listeria monocytogenes." 04/01/2015 - "The aim of this study was to explore the function of IL-23 in determining the distribution of Th lymphocyte subsets (Th1, Th2, and Th17) after RSV infection in vitro. " 04/01/2013 - "Our study showed that Histoplasma infection induced gal3(-/-) dendritic cells to produce significantly higher levels of IL-23, TGF-β1, and IL-1β than did gal3(+/+) cells. " 11/15/2002 - "In the present study we demonstrate that human monocyte-derived macrophages are able to produce IL-23 in response to virus infection. " 08/01/2015 - "Attenuated TNFα and IL-23 release from CD macrophages was found after infection with all E. "
3.	Inflammation 04/30/2011 - "In addition, knockdown of IL-23 expression dramatically reduced the numbers of eosinophils and neutrophils in BALF and mitigated inflammation in the lungs of asthmatic mice. " 02/15/2010 - "IL-23 plays an important role in autoimmune tissue inflammation and induces the generation of not fully characterized effector cells that mediate protection against pathogens. " 07/01/2012 - "Future studies are expected to fully uncover the cytokine-related mechanisms mediating HBV-induced liver inflammation, and to determine the yet unknown cell source of IL-23. " 04/01/2012 - "Recent studies have shown that IL-23 also acts on cells of the innate immune system that can contribute to inflammatory cytokine production and tissue inflammation. " 01/01/2012 - "Our studies demonstrate that IL-23 is a homeostatic regulator of IL-12-dependent, IFN-γ-mediated intestinal inflammation."
4.	Crohn Disease (Crohn's Disease) 01/01/2015 - "Studies investigating the association between Interleukin-23 receptor (IL-23R) gene polymorphisms and Crohn's disease (CD) report conflicting results. " 12/01/2013 - "Associations presented in this study give potentially important insight into the roles of specific Interleukin-23 receptor polymorphisms in Crohn's disease pathogenesis in the Croatian population." 08/01/2010 - "This study was designed to evaluate whether interleukin-23 receptor (IL-23R) polymorphisms were associated with Crohn's disease (CD) susceptibility. " 10/01/2009 - "An association of variants in the genes encoding the interleukin 23 receptor (IL23R, p.Arg381Gln, rs11209026), and the autophagy-related gene 16-like 1 (ATG16L1, p.Ala197Thr, rs2241880) with Crohn disease (CD) was identified by whole genome association studies, and subsequently confirmed by other works. " 09/01/2008 - "Multiple studies have now established the contribution of the interleukin 23 receptor gene (IL23R) to Crohn's disease (CD) risk in general and of the IL23R R381Q variant in particular. "
5.	Neoplasms (Cancer) 10/01/2009 - "IL-23 has been shown to possess potent antitumor activities in several establishment models of cancer and a few therapeutic models, but the efficacy of local, adenoviral-mediated expression of IL-23 in established tumors has yet to be investigated. " 06/01/2012 - "In this study, we demonstrated for the first time that human primary FL and DLBCL cells expressed complete and functional IL-23 and IL-27 receptors (R) and that IL-23 and IL-27 exerted anti-tumor activities in vitro and in vivo through different and complementary mechanisms. " 11/01/2011 - "Although the endogenous IL-23 expression has been reported to promote tumor development and growth, the studies using local and systemic administration of IL-23 have shown that its application at the excessive amount induces antitumor immune responses. " 09/01/2008 - "To study the antitumor effect of IL-23 in mouse mammary cancer and the change of its immune function. " 06/15/2007 - "In this study, we examined the antitumor effects associated with systemic administration of IL-23 and their mechanisms in mouse tumor system. "

Related Drugs and Biologics

1.	Interleukin-12 (IL 12)
2.	Interleukin-17 (Interleukin 27)
3.	monoclonal antibody CNTO 1275 (CNTO 1275)
4.	adjuvant P40 (P 40)
5.	Cytokines
6.	Interleukin-18 (Interleukin 18)
7.	Interleukins
8.	interleukin-22 (IL-22)
9.	Antibodies
10.	Interleukin-6 (Interleukin 6)

Related Therapies and Procedures

1.	Aftercare (After-Treatment)
2.	Injections
3.	Intradermal Injections
4.	Drug Therapy (Chemotherapy)
5.	Electroacupuncture