Ciliary Neurotrophic Factor Receptor alpha Subunit

A ciliary neurotrophic factor receptor subunit. It is anchored to the cell surface via GLYCOSYLPHOSPHATIDYLINOSITOL LINKAGE and has specificity for binding to CILIARY NEUROTROPHIC FACTOR. It lacks signal transducing domains which are found on the other two subunits of the receptor.

Also Known As:

Networked: 19 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Chun, M H: 3 articles (11/2000 - 04/2000)
2.	Hofmann, H D: 3 articles (11/2000 - 04/2000)
3.	Ju, W K: 3 articles (11/2000 - 04/2000)
4.	Kirsch, M: 3 articles (11/2000 - 04/2000)
5.	Lee, M Y: 3 articles (11/2000 - 04/2000)
6.	Oh, S J: 2 articles (11/2000 - 04/2000)
7.	Cronier, Samantha A: 1 article (06/2008)
8.	Dong, Feng: 1 article (06/2008)
9.	Ford, Stephen P: 1 article (06/2008)
10.	Karpman, Adam M: 1 article (06/2008)

Related Diseases

1.	Hepatocellular Carcinoma (Hepatoma) 04/01/2008 - "In this study, we demonstrate that CNTFRalpha is expressed heterogeneously in normal human liver and hepatocellular carcinoma (HCC) specimens but not in hepatoblastoma specimens. " 10/18/1996 - "Similarly, CNTFR3alpha specifically antagonizes the induction of gp130 and LIFRbeta tyrosine phosphorylation observed in response to CNTF and wild type soluble CNTFRalpha in the HepG2 hepatoma cell line, as well as the subsequent events leading to haptoglobin synthesis. "
2.	Overnutrition 06/01/2008 - "This study was designed to examine myocardial expression of ciliary neurotrophic factor receptor alpha (CNTFRalpha) and its downstream mediator signal transducer and activator of transcription 3 (STAT3) on maternal undernutrition- or overnutrition-induced changes in fetal heart weight. "
3.	Malnutrition (Nutritional Deficiencies) 06/01/2008 - "This study was designed to examine myocardial expression of ciliary neurotrophic factor receptor alpha (CNTFRalpha) and its downstream mediator signal transducer and activator of transcription 3 (STAT3) on maternal undernutrition- or overnutrition-induced changes in fetal heart weight. " 06/01/2008 - "These data suggested that, compared with maternal undernutrition, intrauterine overfeeding during early to mid gestation is associated with increases in fetal blood concentrations of cortisol and IGF-1, in association with ventricular hypertrophy where reduced expression of CNTFRalpha and STAT3 may play a role."
4.	Hepatoblastoma 04/01/2008 - "In this study, we demonstrate that CNTFRalpha is expressed heterogeneously in normal human liver and hepatocellular carcinoma (HCC) specimens but not in hepatoblastoma specimens. "
5.	Ganglion Cysts (Ganglion) 12/16/2003 - "In the neonatal retina, intense staining signals for gp130, CNTFRalpha, Jak2, Tyk2, STAT1, and STAT3 were present in the differentiated ganglion cell layer and the developing inner plexiform layer of the mouse retina. " 08/01/2003 - "In the retina, CNTFRalpha was highly expressed by photoreceptors, but both the transcript and protein were also found in the RPE, inner nuclear layer, and ganglion cells. " 02/28/2000 - "The highest CNTFRalpha mRNA signal was found in the ganglion cells of the adrenal medulla. " 04/07/2000 - "In the normal retina, the signal for CNTFRalpha mRNA was present in retinal cells in the inner nuclear layer (INL) and in the ganglion cell layer (GCL). "

Related Drugs and Biologics

1.	Ciliary Neurotrophic Factor Receptor
2.	STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)
3.	Ciliary Neurotrophic Factor (CNTF)
4.	Messenger RNA (mRNA)
5.	Cytokines
6.	Leukemia Inhibitory Factor
7.	Nerve Growth Factor (NGF)
8.	Brain-Derived Neurotrophic Factor (BDNF)
9.	Connexin 43 (Connexin43)
10.	Interleukin-6 (Interleukin 6)

Related Therapies and Procedures

1.	Castration