De Quervain Disease

Stenosing tenosynovitis of the abductor pollicis longus and extensor pollicis brevis tendons in the first dorsal wrist compartment. The presenting symptoms are usually pain and tenderness at the radial styloid. The cause is almost always related to OVERUSE INJURY or is associated with RHEUMATOID ARTHRITIS.

Also Known As:

Networked: 34 relevant articles (4 outcomes, 5 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	De Quervain Disease
2.	Ulnar Neuropathies (Ulnar Neuropathy)
3.	Tenosynovitis
4.	Metaplasia
5.	Carpal Tunnel Syndrome

Experts

1.	Kerckhove, Diederick: 2 articles (08/2015 - 02/2015)
2.	Goubau, Jean F: 2 articles (08/2015 - 02/2015)
3.	van Hoonacker, Petrus: 2 articles (08/2015 - 02/2015)
4.	Berghs, Bart: 2 articles (08/2015 - 02/2015)
5.	Vanmierlo, Bert: 2 articles (08/2015 - 02/2015)
6.	Wu, Kuo-Chen: 2 articles (05/2015 - 01/2015)
7.	Wu, Po-Ting: 2 articles (05/2015 - 01/2015)
8.	Jou, I-Ming: 2 articles (05/2015 - 01/2015)
9.	Bhargava, S K: 1 article (09/2015)
10.	Kumar, Sudhir: 1 article (09/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to De Quervain Disease:

1.	Triamcinolone (Aristocort)FDA Link 04/01/2007 - "The accurate injection of triamcinolone into the sheath of both the extensor pollicis brevis and abductor pollicis longus tendon was considered very effective for de Quervain's disease." 04/01/2007 - "De Quervain's disease: efficacy of intra-sheath triamcinolone injection." 12/01/2013 - "The purpose of this study was to describe the technique and usefulness of ultrasound-guided intrasheath injection of triamcinolone in the treatment of de Quervain's disease (dQD). " 12/01/2013 - "The role of ultrasound-guided triamcinolone injection in the treatment of de Quervain's disease: treatment and a diagnostic tool?" 04/01/2007 - "The methods and clinical outcomes of intra-sheath triamcinolone injection in the treatment of de Quervain's disease are described. "
2.	nimesulide (Aulin)IBA 12/01/2004 - "The symptoms of de Quervain disease recurred in 33% of the patients in the nimesulide group and in 37% of those in the placebo group. " 12/01/2004 - "Treatment of de Quervain disease with triamcinolone injection with or without nimesulide. " 07/01/2009 - "For De Quervain's disease (2 RCTs), we found no efficacy of Nimesulide as addition to a Triamcinolone injection, and no clear differences between a corticosteroid injection and a splint in pregnant patients or patients breast-feeding. " 12/01/2004 - "Supplemental oral administration of the nonsteroidal anti-inflammatory drug nimesulide does not improve the effectiveness of a single injection of triamcinolone acetonide in the treatment of de Quervain disease. " 12/01/2004 - "In a randomized, double-blind trial, 160 patients with de Quervain disease received an injection of 10 mg of triamcinolone acetonide and either 200 mg of oral nimesulide for seven days (eighty patients) or placebo tablets for seven days (eighty patients). "
3.	CortisoneIBA 03/01/2002 - "de Quervain's disease of pregnancy and lactation is self-limited and can be treated successfully with cortisone injection. "
4.	Lidocaine (Xylocaine)FDA LinkGeneric 07/01/1994 - "This study compared the use of a mixed steroid/lidocaine injection alone, an immobilization splint alone, and the simultaneous use of both in improving symptoms in de Quervain's disease. " 12/16/1972 - "Thirty patients with de Quervain's disease were treated by injection of hydrocortisone acetate and lignocaine. "
5.	Triamcinolone Acetonide (Azmacort)FDA LinkGeneric 12/01/2004 - "Supplemental oral administration of the nonsteroidal anti-inflammatory drug nimesulide does not improve the effectiveness of a single injection of triamcinolone acetonide in the treatment of de Quervain disease. " 12/01/2004 - "In a randomized, double-blind trial, 160 patients with de Quervain disease received an injection of 10 mg of triamcinolone acetonide and either 200 mg of oral nimesulide for seven days (eighty patients) or placebo tablets for seven days (eighty patients). "
6.	Technetium (Technetium 99m)IBA 06/01/1984 - "In seven consecutive patients with de Quervain's disease, six had evidence of osseous involvement of the radial styloid as demonstrated by roentgenographic studies and/or technetium bone scanning. "
7.	TabletsIBA 12/01/2004 - "In a randomized, double-blind trial, 160 patients with de Quervain disease received an injection of 10 mg of triamcinolone acetonide and either 200 mg of oral nimesulide for seven days (eighty patients) or placebo tablets for seven days (eighty patients). "
8.	Bupivacaine (Bupivacaine Hydrochloride)FDA LinkGeneric 11/01/2009 - "The aim of this study was to describe the technique and usefulness of ultrasound-guided intrasynovial injection of triamcinolone and bupivacaine in treatment of de Quervain's disease. " 11/01/2009 - "Ultrasound-guided injection of triamcinolone and bupivacaine is safe and useful in controlling symptoms of De Quervain's disease. " 11/01/2009 - "Ultrasound-guided injection of triamcinolone and bupivacaine in the management of De Quervain's disease."
9.	SteroidsIBA 01/01/1990 - "It is concluded that injection of steroids is the preferred initial treatment in de Quervain's disease, giving complete and lasting relief in 80% of cases. " 06/01/2009 - "Tenosynovitis of the first dorsal compartment of the wrist, commonly known as de Quervain disease, is most of the time amenable to conservative treatment in form of splinting and injection of steroids into the compartment. "
10.	CollagenIBA 01/01/1985 - "The results seem to indicate that thickening and hardening of the EPB and APL tendon sheaths in de Quervain's disease is caused by increased synthesis of the extracellular matrix, increased thickness of the collagen fibrils and areas of myxomatous and chondroid metaplasia." 05/01/2015 - "Neutrophil elastase and cyclooxygenase occur in the de Quervain disease retinaculum and increased with the grade of collagen structure. "

Therapies and Procedures

1.	Splints 10/01/1998 - "My doctor has diagnosed De Quervain's disease and has prescribed a splint. " 07/01/1994 - "This study compared the use of a mixed steroid/lidocaine injection alone, an immobilization splint alone, and the simultaneous use of both in improving symptoms in de Quervain's disease. " 07/01/2009 - "For De Quervain's disease (2 RCTs), we found no efficacy of Nimesulide as addition to a Triamcinolone injection, and no clear differences between a corticosteroid injection and a splint in pregnant patients or patients breast-feeding. "
2.	Surgical Decompression 03/01/2000 - "Although surgical decompression for de Quervain's disease is effective in curing the symptoms in most patients, using a longitudinal incision is associated with poor wound healing and damage to the terminal branches of the radial nerve." 09/01/2005 - "The objective of this paper is to contrast the use of a longitudinal incision in surgical decompression of De Quervain disease with a transverse incision. " 10/01/2001 - "An intra-operative "passive gliding" maneuver was performed to identify the extensor pollicis brevis tendon during surgical decompression for de Quervain's disease in 40 involved wrists. "
3.	Decompression 08/01/2015 - "Background Simple decompression of the first extensor compartment is commonly used for treating de Quervain disease, with the possible complication of subluxation of the tendons of the abductor pollicis longus (APL) and extensor pollicis brevis (EPB) over the radial styloid. " 06/01/2011 - "Excision of aberrant abductor pollicis longus tendon slips for decompression of de Quervain's disease." 10/01/2001 - "By performing this intra-operative maneuver surgeons can prevent incomplete decompression in de Quervain's disease, regardless of the anatomical variation of the first extensor compartment." 09/01/1998 - "Limited surgical treatment of de Quervain's disease: decompression of only the extensor pollicis brevis subcompartment." 07/01/1986 - "These features might readily result in inadequate decompression of the compartment in the treatment of de Quervain disease. "
4.	Injections 12/01/2004 - "There is uncertainty as to whether supplemental oral nonsteroidal anti-inflammatory medication improves the effectiveness of steroid injections in the treatment of de Quervain disease. " 05/01/1986 - "A review of 171 such cases treated with steroid injections indicates that injection for trigger finger and de Quervain's disease can be quite successful. " 03/01/2003 - "SUBJECTS AND METHODS Patients with de Quervain's disease who did not respond to conservative treatment with analgesics, splintage and local steroid injections were operated under local anesthesia and the tendons of abductor pollicis longus and extensor pollicis brevis were released. " 05/01/2015 - "• Ultrasound guidance allows for safe injection procedures to treat de Quervains' disease • Steroid injections allow prompt recovery in de Quervain's disease with short-term recurrence • Addition of hyaluronic acid allows recurrence rate reduction compared to simple steroid injections."
5.	Low-Level Laser Therapy (LLLT) 09/01/2015 - "versus LLLT in de Quervain's disease. "