Glypicans

A family of GLYCOSYLPHOSPHATIDYLINOSITOL-anchored, cell-surface heparan sulfate proteoglycans that may play a role in CELL GROWTH PROCESSES and CELL DIFFERENTIATION by modulating ligand-receptor interactions.

Also Known As:

Networked: 413 relevant articles (4 outcomes, 42 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Nakatsura, Tetsuya: 27 articles (01/2016 - 06/2003)
2.	Filmus, Jorge: 13 articles (08/2013 - 07/2003)
3.	Yoshikawa, Toshiaki: 11 articles (01/2016 - 07/2009)
4.	Ho, Mitchell: 11 articles (06/2015 - 02/2011)
5.	Nishimura, Yasuharu: 10 articles (04/2009 - 06/2003)
6.	Yao, Min: 9 articles (08/2015 - 06/2011)
7.	Motomura, Yutaka: 9 articles (07/2012 - 06/2003)
8.	Aburatani, Hiroyuki: 9 articles (06/2009 - 02/2003)
9.	Gao, Wei: 8 articles (06/2015 - 05/2012)
10.	Yang, Ximing J: 8 articles (01/2015 - 12/2006)

Related Diseases

1.	Hepatocellular Carcinoma (Hepatoma) 07/01/2014 - "This study determined the prognostic impact of infiltrating tumour-associated macrophages and the expression of monocarboxylate transporter 4 (MCT4) and glypican 3 (GPC3) in hepatocellular carcinoma (HCC) clinical specimens. " 04/01/2014 - "Japanese phase I study of GC33, a humanized antibody against glypican-3 for advanced hepatocellular carcinoma." 02/01/2014 - "Many individual studies have evaluated the diagnostic efficiency of serum glypican-3 (GPC-3) for diagnosing hepatocellular carcinoma (HCC), but the results have been inconsistent. " 02/15/2013 - "First-in-man phase I study of GC33, a novel recombinant humanized antibody against glypican-3, in patients with advanced hepatocellular carcinoma." 10/01/2012 - "Glypican-3 as a potential differential diagnosis marker for hepatocellular carcinoma: a tissue microarray-based study."
2.	Neoplasms (Cancer) 07/01/2015 - "Recently, Arginase-1 (ARG-1) and Glypican-3 (GPC-3) have been introduced for differentiation of these tumors. " 02/01/2015 - "The expression of glypican-1 is differentially altered among different types of malignancies, suggesting a possible role in the tumorigenesis and biological behavior of these neoplasms. " 02/01/2015 - "Glypican 3 expression in pediatric malignant solid tumors." 01/01/2015 - "Glypican 3 overexpression in primary and metastatic Wilms tumors." 01/01/2015 - "A vaccine that induces cytotoxic T lymphocytes (CTLs) is an ideal strategy for cancer, and glypican-3 (GPC3) is a potential option for HCC. "
3.	Carcinoma (Carcinomatosis) 08/01/2015 - "The tumour was diffusely and strongly positive for hepatocyte paraffin-1 (Hep Par-1) and glypican-3 leading to the diagnosis of hepatoid carcinoma. " 04/01/2015 - "Glypican-3 was immunoexpressed in 97% of cases of HCC while all cases of metastatic carcinoma were negative. " 04/01/2015 - "Fourty eight cell blocks prepared from FNA from the liver ( 30 cases HCC, 18 cases metastatic carcinoma in liver) stained by Glypican -3 and HepPar-1 immunohistochemical markers. " 01/01/2015 - "Expression of Glypican 3 in low and high grade urothelial carcinomas." 03/01/2014 - "IMP3, MAGE-A, glypican-3 and TPBG were expressed in 39.5%, 45%, 6% and 85% of urothelial bladder carcinomas, respectively. "
4.	Endodermal Sinus Tumor (Endodermal Sinus Tumors) 07/01/2014 - "More recently this variant has been found to occasionally produce bile in canalicular-like structures and to stain strongly for both SALL4 and glypican 3, 2 recently described markers of yolk sac tumor. " 05/01/2010 - "OCT4 marked the nuclei of 6 cases, among which 5 cases also showed glypican 3 expression indicative of an admixed yolk sac tumor component. " 12/01/2009 - "All yolk sac tumors showed positive glypican-3 staining (1+ in 6, 2+ in 6, 3+ in 7, and 4+ in 8). " 10/01/2009 - "Yolk sac tumor (YST) was identified by morphology and glypican 3 staining in 20 testicular mixed GCTs. " 06/01/2009 - "All six ovarian yolk sac tumors showed diffuse immunoreactivity for glypican-3. "
5.	Germ Cell and Embryonal Neoplasms (Germ Cell Tumor) 11/01/2014 - "Clinically, we recommend that glypican 3 be used as part of a panel of markers in subtyping testicular germ cell tumors. " 05/01/2012 - "Diagnostic utility of CD117, CD133, SALL4, OCT4, TCL1 and glypican-3 in malignant germ cell tumors of the ovary." 08/01/2008 - "Expression of glypican 3 in ovarian and extragonadal germ cell tumors." 12/01/2006 - "Glypican 3: a novel marker in testicular germ cell tumors." 09/01/2006 - "Oncofetal protein glypican-3 in testicular germ-cell tumor."

Related Drugs and Biologics

1.	Cadherins (E-Cadherin)
2.	Mitoxantrone (Novantrone)
3.	alpha-Fetoproteins (AFP)
4.	Antigens
5.	Proteoglycans (Proteoglycan)
6.	Syndecan-1 (Syndecan 1)
7.	Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)
8.	Syndecan-4
9.	Paraffin
10.	Antibodies

Related Therapies and Procedures

1.	Immunotherapy
2.	Liver Transplantation
3.	Lasers (Laser)
4.	Hepatectomy
5.	Drug Therapy (Chemotherapy)