Syndecan-2

A syndecan that is predominantly expressed during EMBRYONIC DEVELOPMENT. It may play a role in mediating cellular interactions with the EXTRACELLULAR MATRIX and may modulate the signaling activity of certain INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS.

Also Known As:

Networked: 129 relevant articles (1 outcomes, 20 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Oh, Eok-Soo: 24 articles (05/2022 - 08/2002)
2.	Choi, Sojoong: 8 articles (01/2019 - 10/2009)
3.	Jang, Bohee: 7 articles (05/2022 - 12/2016)
4.	Modrowski, Dominique: 7 articles (01/2017 - 08/2005)
5.	Chung, Heesung: 6 articles (01/2017 - 10/2009)
6.	Marie, Pierre J: 6 articles (01/2017 - 08/2005)
7.	Han, Inn-Oc: 6 articles (05/2014 - 10/2009)
8.	Park, Haein: 6 articles (12/2009 - 08/2002)
9.	Rosas, Ivan O: 5 articles (01/2022 - 10/2013)
10.	Tzanakakis, George N: 5 articles (12/2017 - 10/2008)

Related Diseases

1.	Carcinoma (Carcinomatosis) 02/13/2003 - "In contrast, syndecan-2 expression was dramatically reduced and it was correlated with the morphological changes of colon carcinoma cells. " 03/01/2004 - "New insights into syndecan-2 expression and tumourigenic activity in colon carcinoma cells." 08/16/2002 - "Therefore, increased syndecan-2 expression appears to be a critical for colon carcinoma cell behavior, and syndecan-2 regulates tumorigenic activity through regulation of adhesion and proliferation in colon carcinoma cells." 08/16/2002 - "Syndecan-2 mediates adhesion and proliferation of colon carcinoma cells." 03/01/2010 - "Several studies investigated the role of syndecan-2 (SDC2) in different carcinomas; however, only one being focused on SDC2 in prostate cancer. "
2.	Neoplasms (Cancer) 11/01/2017 - "Emerging roles of syndecan 2 in epithelial and mesenchymal cancer progression." 01/01/2014 - "Syndecan 2 levels were very low or undetectable in healthy tissues, increasing significantly in well-differentiated tumors, and decreasing in poorly differentiated NETs, and its expression levels showed a positive correlation with patient survival. " 05/01/2013 - "Syndecan-2 expression in non-malignant stroma was higher in CSCC than in OSCC tumors. " 06/01/2012 - "Here, we show that syndecan-2 has a stronger tumor suppressor activity in vivo. " 05/01/2011 - "First, we assessed the selectivity of AG73-Dox for cancer cells, including syndecan-2 over-expressing cells, using flow cytometry and confocal microscopy. "
3.	Colorectal Neoplasms (Colorectal Cancer) 06/26/2022 - "Some studies on methylated Syndecan 2 (SDC2) have shown that it has a great diagnostic ability in colorectal cancer. " 01/01/2020 - "In this study, we aimed to elucidate the biological roles of Syndecan-2 (SDC2) in colorectal cancer (CRC), thereby further understanding its clinical role. " 10/01/2023 - "Syndecan-2 modulates the YAP pathway in epithelial-to-mesenchymal transition-related migration, invasion, and drug resistance in colorectal cancer." 01/01/2023 - "To explore the clinical value of human fecal Syndecan-2 (SDC2) gene methylation in colorectal cancer screening. " 01/01/2022 - "The Application Value of Syndecan-2 Gene Methylation for Colorectal Cancer Diagnosis: A Clinical Study and Meta-Analyses."
4.	Colonic Neoplasms (Colon Cancer) 08/16/2002 - "Cell biological studies using the extracellular domain of recombinant syndecan-2 (2E) or spreading assay with syndecan-2 antibody-coated plates showed that syndecan-2 mediated adhesion and cytoskeletal organization of colon cancer cells. " 08/16/2002 - "In this study, we examined the function of syndecan-2 in colon cancer cell lines. " 01/01/2022 - "Using an orthotopic mouse model of colon cancer, we show that shed syndecan-2 increases colon cancer progression by cooperatively promoting angiogenesis. " 01/01/2022 - "Although shed syndecan-2 potentiated the tumorigenic activities of colon cancer cells, how shed syndecan-2 increases this tumorigenic potential remains unclear. " 01/01/2022 - "Shed syndecan-2 enhances colon cancer progression by increasing cooperative angiogenesis in the tumor microenvironment."
5.	Osteosarcoma (Osteogenic Sarcoma) 08/01/2005 - "In this study, we examined the role of syndecan-2 in osteosarcoma cell proliferation and apoptosis. " 07/01/2010 - "Our results identify syndecan-2 as a Wnt target and bring new insights into a possible pathologic role of Wnt signaling in osteosarcoma." 07/01/2010 - "The high activity of the canonical Wnt pathway in the different osteosarcoma cells induces a constitutive repression of syndecan-2 transcription, whereas Wnt/RhoA signaling blocks the amplification loop of syndecan-2 expression. " 07/01/2010 - "The alteration of syndecan-2 expression in osteosarcoma cell lines also seemed to be related to a higher shedding, controlled by Wnt/RhoA. " 07/01/2010 - "We compared the regulatory activity of cis-acting DNA sequences of the syndecan-2 gene in osteosarcoma and osteoblastic cell lines. "

Related Drugs and Biologics

1.	Heparan Sulfate Proteoglycans (Heparan Sulfate Proteoglycan)
2.	Proteoglycans (Proteoglycan)
3.	Syndecan-1 (Syndecan 1)
4.	Liposomes (Liposome)
5.	Heparitin Sulfate (Heparan Sulfate)
6.	Proteins (Proteins, Gene)
7.	Syndecan-4
8.	Fibronectins (Fibronectin)
9.	Catenins
10.	Glycosaminoglycans

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Operative Surgical Procedures
4.	Punctures
5.	Ligation