Syndecans

A family of transmembrane glycoproteins that contain a short cytoplasmic domain, a single-span transmembrane domain, and an extracellular domain with heparin sulfate and CHONDROITIN SULFATE chains. Syndecans interact with a variety of heparin-binding INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS and may play a role in modulating cellular signaling during EMBRYONIC DEVELOPMENT, tumorigenesis, and angiogenesis.

Also Known As:

Networked: 263 relevant articles (5 outcomes, 21 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Fisher, Paul B: 8 articles (01/2021 - 11/2004)
2.	Sarkar, Devanand: 8 articles (01/2021 - 11/2004)
3.	Couchman, John R: 8 articles (01/2017 - 01/2007)
4.	Rapraeger, Alan C: 7 articles (01/2022 - 06/2003)
5.	Das, Swadesh K: 7 articles (01/2021 - 10/2017)
6.	Emdad, Luni: 7 articles (01/2021 - 10/2017)
7.	Karamanos, Nikos K: 6 articles (01/2017 - 11/2002)
8.	Multhaupt, Hinke A B: 6 articles (01/2017 - 01/2007)
9.	Beauvais, DeannaLee M: 5 articles (01/2022 - 06/2003)
10.	Oh, Eok-Soo: 5 articles (01/2022 - 03/2011)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2011 - "Our study provides new insights into better understanding of the role of syndecans in tumor progression." 08/01/2005 - "Studies in cancer cells suggest that syndecans may also modulate cell viability. " 01/07/2004 - "However, several emerging studies point to critical roles for the syndecans' extracellular protein domains in tumor cell behavior to include cell adhesion and invasion. " 07/01/2023 - "HSPGs, particularly the syndecans (SDCs), have been linked to cancers, making them an exciting target for anticancer treatments. " 01/01/2023 - "Since syndecans have potential as diagnostic and prognostic markers as well as possible targets in some forms of cancer, it remains important to unravel structure/function relationships in the four mammalian syndecans."
2.	Fibrosis (Cirrhosis) 01/01/2016 - "Graphical Abstract Graphical abstract summarizing the contents of the current review on syndecans in cardiac fibrosis. " 01/01/2016 - "We review the current literature concerning syndecans in cardiac fibrosis. " 01/01/2016 - "Syndecans in heart fibrosis." 12/01/2012 - "These data provide an additional dimension to syndecan function related to tension at the cell-matrix interface, wound healing and potentially fibrosis." 01/01/2016 - "The signaling and cellular processes governed by syndecans in the heart in response to pathological stimuli regulate important aspects of extracellular matrix remodeling and fibrosis and have mainly been studied in cardiac remodeling in response to cardiac infarction and pressure overload. "
3.	Wounds and Injuries (Trauma) 01/01/1993 - "Because changes in syndecan expression enable cells to become more or less responsive to their microenvironment, understanding these regulatory mechanisms can lead to an improved understanding of how cellular behavior is controlled during development and wound repair." 08/01/2022 - "Endotheliopathy of trauma (EoT), as defined by circulating levels of syndecan-1 ≥ 40 ng/mL, has been reported to be associated with significantly increased transfusion requirements and a doubled 30-day mortality. " 03/31/2009 - "Syndecans influence a wide range of physiological processes, but their contribution is most apparent during wound repair. " 05/08/1998 - "Thus, syndecans are shed into acute wound fluids, where they can modify the proteolytic balance of the fluid. " 06/06/1997 - "Therefore, we examined (i) whether physiological agents active during wound repair influence syndecan shedding, and (ii) whether wound fluids contain shed syndecan ectodomains. "
4.	Infections 12/01/2005 - "aeruginosa infection of thermal injury and that syndecan 1-neutralizing agents may be effective supplements to current P. " 05/01/2005 - "hermsii and up-regulate the activation markers syndecan I and B7.1 within 16 h of infection. " 09/01/2015 - "Conversely, during the luteal phase there were factors overexpressed (including moesins, syndecans, and integrins, among others) that could play direct or indirect roles in enhancing HIV-1 infection. " 12/01/2008 - "The liver response to infection demonstrated strain-specific compensatory increases of antithrombin and syndecan gene transcription. " 04/10/2008 - "All together, our results confirm the essential role of HS in MHV68 infection and identify the syndecans as a major source of HSPG used by the virus as coreceptors to infect CHO cells."
5.	Heart Diseases (Heart Disease) 01/01/2016 - "Syndecan expression is up-regulated in response to pro-inflammatory stimuli in various forms of heart disease with fibrosis. " 01/01/2016 - "Improved understanding of syndecans and their modifying enzymes in cardiac fibrosis might contribute to the development of compounds with therapeutic potential, and enzymatically shed syndecan ectodomains might constitute a future prognostic tool for heart diseases with fibrosis. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Syndecans
3.	Enzymes
4.	Peptides (Polypeptides)
5.	Membrane Proteins (Integral Membrane Proteins)
6.	Type C Phospholipases
7.	heparitinsulfate lyase
8.	Heparan Sulfate Proteoglycans (Heparan Sulfate Proteoglycan)
9.	Carrier Proteins (Binding Protein)
10.	Integrins

Related Therapies and Procedures

1.	Induction Chemotherapy
2.	Therapeutics
3.	Vitrectomy
4.	Radiotherapy
5.	Ligation