Interleukin-13 Receptor alpha1 Subunit

An interleukin receptor subunit with specificity for INTERLEUKIN-13. It dimerizes with the INTERLEUKIN-4 RECEPTOR ALPHA SUBUNIT to form the TYPE II INTERLEUKIN-4 RECEPTOR which has specificity for both INTERLEUKIN-4 and INTERLEUKIN-13. Signaling of this receptor subunit occurs through the interaction of its cytoplasmic domain with JANUS KINASES such as the TYK2 KINASE.

Also Known As:

Networked: 23 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Joshi, Bharat H: 3 articles (01/2006 - 06/2004)
2.	Puri, Raj K: 3 articles (01/2006 - 12/2003)
3.	Ahmad, A S: 1 article (01/2011)
4.	El-Shal, A S: 1 article (01/2011)
5.	Elsherbeny, H M: 1 article (01/2011)
6.	Hussein, Y M: 1 article (01/2011)
7.	Ibrahem, M M: 1 article (01/2011)
8.	Sabbah, N A: 1 article (01/2011)
9.	Shalaby, S M: 1 article (01/2011)
10.	Bandeira, Angela: 1 article (09/2010)

Related Diseases

1.	Asthma (Bronchial Asthma) 07/01/2007 - "Genetic association studies of interleukin-13 receptor alpha1 subunit gene polymorphisms in asthma and atopy." 07/01/2007 - "The genetic diversity at the IL-13Ralpha1 gene (IL13RA1) locus on chromosome Xq24 was characterised and the association of identified polymorphisms with asthma and atopy phenotypes examined. " 07/01/2007 - "These findings indicate that the interleukin-13 receptor alpha1 subunit gene -281T>G and 1365A>G polymorphisms do not contribute to asthma susceptibility or severity, although the interleukin-13 receptor alpha1 subunit gene locus might be involved in the control of immunoglobulin E production." 03/01/2000 - "A non-coding variant of IL-13Ralpha1, A1398G, on chromosome Xq13, associated primarily with high IgE levels (OR = 3. 38 in males, 1.10 in females) rather than asthma. " 01/01/2011 - "We genotyped the 1398A>G polymorphism in the IL-13Ralpha1 gene using restriction fragment length polymorphism for causal genetic diversity and measured serum levels of IL-13Ralpha2 in 105 atopic patients suffering from atopic asthma, atopic dermatitis, and atopic rhinitis (35 each). "
2.	Hyperoxia 04/15/2007 - "In this study, we demonstrate that hyperoxia significantly augments the expression of the components of the IL-13R, IL-13Ralpha1, and IL-4Ralpha. "
3.	Neoplasms (Cancer) 12/15/2003 - "Extensive analysis demonstrated that the majority of SCCHN tumors uniformly expressed low levels of IL-13Ralpha1 chain; however, 77% of the tumors expressed moderate to high levels of IL-4Ralpha, which forms a signaling complex with IL-13Ralpha1 chain. " 11/19/1999 - "The characterization of both the IL-13Ralpha1 promoter and the transcription factors binding to it may contribute to our understanding of IL-13Ralpha1 regulation in cancer cells." 01/01/2006 - "The IL-13Ralpha2 but not IL-13Ralpha1 chain binds IL-13 with high affinity and is overexpressed in a variety of human cancer cells derived from glioma, squamous cell carcinoma of head and neck, and AIDS-associated Kaposi's sarcoma. "
4.	Infections 09/01/2005 - "Epithelial cells expressed the IL-13 signaling receptor, IL-13Ralpha1, and after infection, IL-4Ralpha. " 10/01/2004 - "Results indicated that within 14 days following infection, overall mRNA levels for IL-4Ralpha and IL-13Ralpha1 were elevated in T. "
5.	Vascular Remodeling 09/01/2010 - "In addition, gain-of-function IL-13Ralpha2(-/-) mice had exacerbated vascular remodeling and PH. Mice with loss of IL-13Ralpha1 function did not develop PH and had reduced pulmonary vascular remodeling. "

Related Drugs and Biologics

1.	Interleukin-13
2.	Interleukin-4 (Interleukin 4)
3.	Immunoglobulin E (IgE)
4.	Messenger RNA (mRNA)
5.	Proto-Oncogene Proteins c-kit (Proto-Oncogene Protein c-kit)
6.	IgE Receptors (Fc epsilon RI)
7.	Transforming Growth Factor beta (TGF-beta)
8.	Cytokines
9.	Transcription Factors (Transcription Factor)
10.	RNA (Ribonucleic Acid)

Related Therapies and Procedures

1.	Resistance Training