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Interleukin-13 Receptors (Interleukin 13 Receptor)

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Cell surface receptors for INTERLEUKIN-13. Included under this heading are the INTERLEUKIN-13 RECEPTOR ALPHA2 which is a monomeric receptor and the INTERLEUKIN-4 RECEPTOR TYPE II which has specificity for both INTERLEUKIN-4 and INTERLEUKIN-13.

Also Known As:

Interleukin 13 Receptor; Receptors, Interleukin-13; IL-13 Receptor; Interleukin-13 Receptor; Receptor, Interleukin-13; IL 13 Receptor; IL 13 Receptors; Interleukin 13 Receptors; Receptor, IL-13; Receptor, Interleukin 13; Receptors, IL-13; Receptors, Interleukin 13; IL-13 Receptors

Networked: 151 relevant articles (6 outcomes, 15 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins
- Proteins: 90489
  - Membrane Proteins: 5300
    - Cell Surface Receptors: 753
      - Immunologic Receptors: 8
        Cytokine Receptors: 788
        Interleukin Receptors: 68
        Interleukin-13 Receptors: 151
        Interleukin-13 Receptor alpha2 Subunit: 46
        Type II Interleukin-4 Receptors: 1

Experts

1.	Puri, Raj K: 27 articles (09/2015 - 02/2002)
2.	Kawakami, Koji: 11 articles (09/2005 - 02/2002)
3.	Joshi, Bharat H: 9 articles (09/2015 - 06/2002)
4.	Husain, Syed R: 9 articles (01/2013 - 08/2002)
5.	Kawakami, Mariko: 9 articles (09/2006 - 02/2002)
6.	Debinski, Waldemar: 7 articles (01/2013 - 08/2003)
7.	Gibo, Denise M: 7 articles (01/2013 - 08/2003)
8.	Puri, R K: 7 articles (05/2004 - 03/2000)
9.	Leland, Pamela: 5 articles (09/2015 - 06/2002)
10.	Kioi, Mitomu: 5 articles (03/2009 - 05/2004)

Related Diseases

1.	Neoplasms (Cancer) 10/20/2015 - "IL-13 receptor subunit alpha-2 (IL13Rα2) is associated with poor prognosis in some cancers. " 07/01/2015 - "Eligible patients had confirmed IL-13 receptor alpha 2 (IL-13Rα2) expressions in their tumors. " 08/01/2014 - "Targeting a heterogeneous tumor: the promise of the interleukin-13 receptor α2." 04/01/2012 - "The human interleukin-13 receptor α2 (IL-13Rα2) is uniquely overexpressed in many different human tumors, making it an attractive target for cancer therapy. " 05/01/2010 - "Expression of IL-13 receptor chains on IECs obtained from control or chronically inflamed mucosa and colonic tumors was quantified by flow cytometry and immunoblot. "
2.	Glioma (Gliomas) 01/01/2015 - "Based on interleukin-13 receptor α2 (IL-13Rα2) over-expression on glioma cell, it was demonstrated to be a potential receptor for glioma targeting. " 07/01/2014 - "Nanoparticles functionalized with Pep-1 as potential glioma targeting delivery system via interleukin 13 receptor α2-mediated endocytosis." 07/01/2012 - "Interleukin-13 receptor α2: glioma's unlucky receptor?" 01/01/2010 - "Decreasing expression of the interleukin-13 receptor IL-13Ralpha2 in treated recurrent malignant gliomas." 12/15/2007 - "The interleukin-13 receptor alpha 2 (IL-13R alpha 2) is a glioma-restricted cell-surface epitope not otherwise detected within the central nervous system. "
3.	Asthma (Bronchial Asthma) 01/01/2000 - "Novel polymorphism in the coding region of the IL-13 receptor alpha' gene: association study with atopic asthma in the Japanese population." 10/01/2013 - "IL-13 receptor α2 contributes to development of experimental allergic asthma." 06/15/2011 - "IL-13 receptor subunits are differentially expressed in asthma. " 06/15/2011 - "At baseline, in airway tissue, IL-13 receptors were expressed in significantly higher levels in asthma, compared with normal control subjects. " 01/01/2010 - "Upregulation of interleukin-13 receptor chains in bronchial smooth muscle tissues of mouse experimental asthma."
4.	Brain Neoplasms (Brain Tumor) 01/01/2013 - "We have taken a bioinformatics approach towards understanding the biological context of IL-13 receptor α2 (IL13Rα2) expression in brain tumors, and its functional significance for patient survival. " 01/01/2012 - "Interleukin 13 receptor α 2 (IL-13Rα2) is a glioblastoma multiforme (GBM)-associated plasma membrane receptor, a brain tumor of dismal prognosis. " 03/01/2009 - "Efficacy of interleukin-13 receptor-targeted liposomal doxorubicin in the intracranial brain tumor model." 02/01/2007 - "However, malignant brain tumors have been found to overexpress a glioma-associated receptor, interleukin-13 receptor alpha2 chain (IL-13Ralpha2), a marker of both glial transformation and tumor grade. " 03/01/2009 - "Recent studies show that interleukin-13 receptor [alpha]2 chain (IL-13Ra2), a brain tumor-associated receptor for IL-13, may play a role in immunotherapy for glioblastoma. "
5.	Infection 07/01/2011 - "Because murine lymphocytes do not have IL-13 receptors, we examined the ability of macrophage/neutrophil-specific IL-4Rα(-/-) mice to control primary infection with L. " 10/01/2004 - "mansoni infection, and succumb to the disease at an accelerated rate; thus, identifying the 'decoy' IL-13 receptor as a critical life sustaining 'off' switch for tissue damaging egg-induced inflammation." 04/01/2008 - "Addition of the point mutations stabilized the weak subunit association observed in some IL-13L-modified Env proteins, but infection via the target IL-13 receptor still did not occur. " 10/01/2004 - "Molecular cloning of the swine IL-4 receptor alpha and IL-13 receptor 1-chains: effects of experimental Toxoplasma gondii, Ascaris suum and Trichuris suis infections on tissue mRNA levels." 08/15/2001 - "Separate groups of BALB/c mice were drug-cured of initial infection and later reinfected and treated with anti-IL-4R mAb, an antagonist of IL-4 and IL-13 receptor binding, or with a control mAb. Segments of jejunum were mounted in Ussing chambers, and short circuit current responses to acetylcholine, histamine, serotonin, PGE2, and glucose were determined. "

Related Drugs and Biologics

1.	Interleukin-4 (Interleukin 4)
2.	IL13-PE38QQR
3.	Dinoprostone (PGE2)
4.	Serotonin (5 Hydroxytryptamine)
5.	Histamine (Histamine Dihydrochloride)
6.	Glucose (Dextrose)
7.	Doxorubicin (Adriamycin)
8.	Acetylcholine (Acetylcholine Chloride)
9.	Interleukin-13
10.	Exotoxins

Related Therapies and Procedures

1.	Heterologous Transplantation (Xenotransplantation)
2.	Immunotherapy