Interleukin-3 Receptor alpha Subunit

A low affinity interleukin-3 receptor subunit that combines with the CYTOKINE RECEPTOR COMMON BETA SUBUNIT to form a high affinity receptor for INTERLEUKIN-3.

Also Known As:

CD123 Antigen; Interleukin-3 Receptor alpha Chain; alpha-Subunit, Receptor, Interleukin-3; Antigen, CD123; Interleukin 3 Receptor alpha Chain; Interleukin 3 Receptor alpha Subunit; Antigens, CD123; CD123 Antigens

Networked: 20 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Membrane Proteins: 10078
    - Cell Surface Receptors: 2125
      - Immunologic Receptors: 9
        Cytokine Receptors: 1620
        Interleukin Receptors: 114
        Interleukin-3 Receptors: 97
        Interleukin-3 Receptor alpha Subunit: 20
        human IL3RA protein

Experts

1.	Testa, Ugo: 3 articles (09/2019 - 08/2004)
2.	Uckun, Fatih M: 2 articles (01/2021 - 01/2021)
3.	Diverio, Daniela: 2 articles (10/2005 - 08/2004)
4.	Peschle, Cesare: 2 articles (10/2005 - 08/2004)
5.	Riccioni, Roberta: 2 articles (10/2005 - 08/2004)
6.	Cheng, Wei: 1 article (06/2021)
7.	He Young, Ken: 1 article (06/2021)
8.	Tang, Ai-Ping: 1 article (06/2021)
9.	Yu, Li: 1 article (06/2021)
10.	Yu, Tian-Tian: 1 article (06/2021)

Related Diseases

1.	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 08/01/2004 - "In a previous study we have shown that the interleukin-3 receptor alpha chain (IL-3Ralpha) is over expressed in about 45% of acute myeloid leukemias (AMLs) and this phenomenon was associated with high blast cell counts at diagnosis, high rate of cycling of leukemic blasts and with a worse prognosis. " 10/01/2005 - "Leukemic blasts from patients with acute myeloid leukemia (AML) frequently express high levels of the interleukin-3 receptor alpha chain (IL-3Ralpha). " 08/01/2004 - "Immunophenotypic features of acute myeloid leukemias overexpressing the interleukin 3 receptor alpha chain." 10/01/2000 - "The interleukin-3 receptor alpha chain is a unique marker for human acute myelogenous leukemia stem cells." 05/01/2019 - "Aberrant expression of the interleukin-3 receptor alpha chain (IL3RA or CD123) is frequently observed in patients with a subset of leukemic disorders, including acute myeloid leukemia (AML), particularly in leukemia stem cells. "
2.	Neoplasms (Cancer) 01/01/2018 - "Here, we report on the robust anti-tumor activity of a compound CAR (cCAR) T-cell possessing discrete scFv domains targeting two different AML antigens, CD123, and CD33, simultaneously. " 06/01/2004 - "The tumor cells share a great phenotypical homology and particularly the expression of the CD123 antigen. " 10/01/2018 - "We have, therefore, directly compared functional co-inhibition in engineered T cells identically targeted to the tumor-associated antigen CD123, but distinct in their mode of T-cell activation: via the endogenous T-cell receptor (ENG), or downstream of CD28 or 41BB-containing CARs. " 09/01/2007 - "The recent discovery of CD123 antigen expression by tumor cells has provided evidence for a relationship to immature dendritic cells (DCs), a group of myeloid and lymphoid early-committed progenitors capable of differentiating into antigen-presenting DCs. " 09/12/2019 - "The interleukin-3 receptor alpha chain (IL-3R), more commonly referred to as CD123, is widely overexpressed in various hematological malignancies, including acute myeloid leukemia (AML), B-cell acute lymphoblastic leukemia, hairy cell leukemia, Hodgkin lymphoma and particularly, blastic plasmacytoid dendritic neoplasm (BPDCN). "
3.	Leukemia 11/15/2016 - "Overexpressed interleukin-3 receptor alpha chain, CD123, on the surface of leukemia stem cells was reported to be a potential target in AML treatment. " 10/01/2003 - "The morphologic, cytochemical and immunophenotypic features were compatible with those described in DC2 acute leukemia, with co-expression of CD4, CD56 and CD123 antigens. " 05/01/2019 - "Aberrant expression of the interleukin-3 receptor alpha chain (IL3RA or CD123) is frequently observed in patients with a subset of leukemic disorders, including acute myeloid leukemia (AML), particularly in leukemia stem cells. " 12/19/2003 - "Promyelocytic leukemia zinc finger (PLZF) protein is a sequence-specific DNA-binding protein that represses the transcriptional activity of target genes such as those for cyclin A and the interleukin-3 receptor alpha chain. "
4.	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 01/01/2021 - "High Expression of Interleukin-3 Receptor Alpha Chain (CD123) Predicts Favorable Outcome in Pediatric B-Cell Acute Lymphoblastic Leukemia Lacking Prognosis-Defining Genomic Aberrations." 09/12/2019 - "The interleukin-3 receptor alpha chain (IL-3R), more commonly referred to as CD123, is widely overexpressed in various hematological malignancies, including acute myeloid leukemia (AML), B-cell acute lymphoblastic leukemia, hairy cell leukemia, Hodgkin lymphoma and particularly, blastic plasmacytoid dendritic neoplasm (BPDCN). "
5.	Hematologic Neoplasms (Hematological Malignancy) 12/01/2001 - "Interleukin-3 receptor alpha chain (CD123) is widely expressed in hematologic malignancies." 09/12/2019 - "The interleukin-3 receptor alpha chain (IL-3R), more commonly referred to as CD123, is widely overexpressed in various hematological malignancies, including acute myeloid leukemia (AML), B-cell acute lymphoblastic leukemia, hairy cell leukemia, Hodgkin lymphoma and particularly, blastic plasmacytoid dendritic neoplasm (BPDCN). "

Related Drugs and Biologics

1.	Antigens
2.	Cyclin A
3.	Biomarkers (Surrogate Marker)
4.	Transcription Factors (Transcription Factor)
5.	T-Cell Antigen Receptors (T-Cell Receptor)
6.	Proteins (Proteins, Gene)
7.	Interleukins
8.	DNA-Binding Proteins (DNA Binding Protein)
9.	Monoclonal Antibodies
10.	Chimeric Antigen Receptors