HOME PRODUCTS SERVICES COMPANY CONTACT FAQ

Interferon alpha-beta Receptor (Receptor, Interferon alpha beta)

Subscribe to New Research on Interferon alpha-beta Receptor

A ubiquitously expressed heterodimeric receptor that is specific for both INTERFERON-ALPHA and INTERFERON-BETA. It is composed of two subunits referred to as IFNAR1 and IFNAR2. The IFNAR2 subunit is believed to serve as the ligand-binding chain; however both chains are required for signal transduction. The interferon alpha-beta receptor signals through the action of JANUS KINASES such as the TYK2 KINASE.

Also Known As:

Receptor, Interferon alpha beta; Receptor, Interferon alpha-beta; IFN-alphaR; IFN-alphabetaR; IFNAR1 Subunit, Interferon alpha-beta Receptor; IFNAR2 Subunit, Interferon alpha-beta Receptor; IFNAR2.1 Subunit, Interferon alpha-beta Receptor; IFNAR2.2 Subunit, Interferon alpha-beta Receptor; Interferon alpha Receptor; Interferon alpha Receptors; Interferon alpha-beta Receptor Chain 1; Interferon alpha-beta Receptor Chain 2; Interferon alpha-beta Receptor IFNAR1 Subunit; Interferon alpha-beta Receptor IFNAR2 Subunit; Interferon alpha-beta Receptor-1; Interferon alpha-beta Receptor-2; Interferon alphabeta Receptors; Receptor, Interferon alpha; Type I Interferon Receptor; IFN alphabetaR; IFNAR1 Subunit, Interferon alpha beta Receptor; IFNAR2 Subunit, Interferon alpha beta Receptor; IFNAR2.1 Subunit, Interferon alpha beta Receptor; IFNAR2.2 Subunit, Interferon alpha beta Receptor; Interferon alpha beta Receptor; Interferon alpha beta Receptor 1; Interferon alpha beta Receptor 2; Interferon alpha beta Receptor Chain 1; Interferon alpha beta Receptor Chain 2; Interferon alpha beta Receptor IFNAR1 Subunit; Interferon alpha beta Receptor IFNAR2 Subunit; Receptor-1, Interferon alpha-beta; Receptor-2, Interferon alpha-beta; Receptors, Interferon alpha; Receptors, Interferon alphabeta; alpha Receptor, Interferon; alpha Receptors, Interferon; alpha-beta Receptor-1, Interferon; alpha-beta Receptor-2, Interferon

Networked: 130 relevant articles (5 outcomes, 10 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins
- Proteins: 90489
  - Membrane Proteins: 5300
    - Cell Surface Receptors: 753
      - Immunologic Receptors: 8
        Cytokine Receptors: 788
        Interferon Receptors: 67
        Interferon alpha-beta Receptor: 130
        human IFNAR1 protein
        human IFNAR2 protein
        mouse Ifnar1 protein
        mouse Ifnar2 protein

Experts

1.	Calvo-Pinilla, Eva: 4 articles (04/2015 - 11/2010)
2.	Kalinke, Ulrich: 4 articles (03/2015 - 11/2006)
3.	Ortego, Javier: 3 articles (04/2015 - 11/2010)
4.	Castillo-Olivares, Javier: 3 articles (04/2015 - 02/2014)
5.	Gubbins, Simon: 3 articles (04/2015 - 02/2014)
6.	Yanai, Yoshiaki: 3 articles (06/2011 - 01/2007)
7.	Mertens, Peter Paul Clement: 2 articles (04/2015 - 02/2014)
8.	de la Poza, Francisco: 2 articles (04/2015 - 02/2014)
9.	Volz, Asisa: 2 articles (09/2014 - 04/2011)
10.	Sutter, Gerd: 2 articles (09/2014 - 04/2011)

Related Diseases

1.	Chronic Hepatitis C 01/01/2010 - "Quantitative analysis of interferon alpha receptor subunit 1 and suppressor of cytokine signaling 1 gene transcription in blood cells of patients with chronic hepatitis C." 07/01/2002 - "Expression of type I interferon receptor in liver and peripheral blood mononuclear cells in chronic hepatitis C patients." 11/01/1998 - "Expression of interferon alpha/beta receptor in the liver of chronic hepatitis C patients." 01/01/2003 - "The concentration of type I interferon receptor (IFN-Rc) in the liver is a crucial factor in determining the efficacy of interferon (IFN) therapy in patients with chronic hepatitis C. " 01/01/2005 - "Promoter polymorphisms of the interferon-alpha receptor gene and development of Interferon-induced depressive symptoms in patients with chronic hepatitis C: preliminary findings."
2.	Renal Cell Carcinoma (Grawitz Tumor) 05/01/2000 - "Serum soluble interferon alpha/beta receptor (s-IFN-receptor) levels were determined in renal cell carcinoma (RCC) patients to study the clinical significance of the measurement. " 05/01/1999 - "Expression of type I interferon receptor in renal cell carcinoma." 01/01/2007 - "Increased interferon alpha receptor 2 mRNA levels is associated with renal cell carcinoma metastasis." 06/01/2011 - "Serum interferon alpha receptor 2 mRNA may predict efficacy of interferon alpha with/without low-dose sorafenib for metastatic clear cell renal cell carcinoma."
3.	Multiple Sclerosis 11/01/2011 - "Complex association analysis of copaxone (glatiramer acetate) immunotherapy efficacy with allelic polymorphism in the number of immune response genes, which encode interferone beta (IFNB1), transforming growth factor beta1 (TGFB1), interferone gamma (IFNG), tumor necrosis factor (TNF), interferon alpha/beta receptor 1 (IFNAR1), CC chemokine receptor 5 (CCR5), interleukin 7 receptor alpha subunit (IL7RA), cytotoxic T-lymphocyte antigen 4 (CTLA4) and HLA class II histocompatibility antigen beta chain (DRB1) was performed with APSampler algorithm for 285 multiple sclerosis patients of Russian ethnicity. "
4.	Fibrosis (Cirrhosis) 03/01/1997 - "Logistic analysis and multiple regression analysis showed that the amount of interferon-alpha receptor mRNA was significantly associated with the efficacy of interferon (p=0.0275), but not with fibrosis of the liver (p= 0.2726). "
5.	Bacterial Infections (Bacterial Infection) 11/01/2012 - "Moreover, mice deficient in type I interferon receptor (IFNAR knockout [KO] mice) effectively cleared the secondary bacterial infection from their lungs, increased the recruitment of neutrophils, and demonstrated an enhanced innate expression of interleukin-17 (IL-17) relative to wild-type (WT) mice. "

Related Drugs and Biologics

1.	Interferons
2.	Messenger RNA (mRNA)
3.	Interferon-alpha (Interferon Alfa)
4.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
5.	Transforming Growth Factor beta1 (TGF beta 1)
6.	Interleukin-7 Receptor alpha Subunit
7.	Interleukin-17 (Interleukin 27)
8.	CCR5 Receptors (CCR5 Receptor)
9.	Histocompatibility Antigens (Histocompatibility Antigen)
10.	sorafenib (BAY 43-9006)

Related Therapies and Procedures

1.	Immunotherapy
2.	Transplantation (Transplant Recipients)