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Interleukin Receptor Common gamma Subunit

An interleukin receptor subunit that was originally discovered as a component of the INTERLEUKIN 2 RECEPTOR. It was subsequently found to be a component of several other receptors including the INTERLEUKIN 4 RECEPTOR, the INTERLEUKIN 7 RECEPTOR, the INTERLEUKIN-9 RECEPTOR, the INTERLEUKIN-15 RECEPTOR, and the INTERLEUKIN-21 RECEPTOR. Mutations in the gene for the interleukin receptor common gamma chain have been associated with X-LINKED COMBINED IMMUNODEFICIENCY DISEASES.
Also Known As:
CD132 Antigen; Common Cytokine Receptor gamma Subunit; Common gamma-Chain Protein; Cytokine Receptor Common gamma Chain; Interleukin Receptor Common gamma-Chain; Interleukin-15 Receptor gamma Chain; Interleukin-2 Receptor gamma Chain; Interleukin-21 Receptor gamma Chain; Interleukin-4 Receptor gamma Chain; Interleukin-7 Receptor gamma Chain; Antigen, CD132; Common gamma Chain Protein; Interleukin 15 Receptor gamma Chain; Interleukin 15 Receptor gamma Subunit; Interleukin 2 Receptor gamma Chain; Interleukin 2 Receptor gamma Subunit; Interleukin 21 Receptor gamma Chain; Interleukin 21 Receptor gamma Subunit; Interleukin 4 Receptor gamma Chain; Interleukin 4 Receptor gamma Subunit; Interleukin 7 Receptor gamma Chain; Interleukin 7 Receptor gamma Subunit; Interleukin Receptor Common gamma Chain; gamma-Chain Protein, Common; Antigens, CD132; CD132 Antigens; Interleukin-15 Receptor gamma Subunit; Interleukin-2 Receptor gamma Subunit; Interleukin-21 Receptor gamma Subunit; Interleukin-4 Receptor gamma Subunit; Interleukin-7 Receptor gamma Subunit; Receptors, Interleukin Common gamma Chain
Networked: 42 relevant articles (1 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Ito, Mamoru: 3 articles (06/2014 - 02/2005)
2. Abe, Tomoyuki: 2 articles (04/2020 - 05/2018)
3. Hanazono, Yutaka: 2 articles (04/2020 - 05/2018)
4. Hara, Hiromasa: 2 articles (04/2020 - 05/2018)
5. Nureki, Osamu: 2 articles (04/2020 - 05/2018)
6. Shibata, Hiroaki: 2 articles (04/2020 - 05/2018)
7. Uosaki, Hideki: 2 articles (04/2020 - 05/2018)
8. Shultz, Leonard D: 2 articles (12/2009 - 10/2009)
9. Byambaa, Suvd: 1 article (04/2020)
10. Nagao, Yasumitsu: 1 article (04/2020)

Related Diseases

1. Nasal Polyps (Nasal Polyp)
2. Severe Combined Immunodeficiency (Bare Lymphocyte Syndrome)
04/22/2020 - "In the present study, we engrafted NPC biopsies in non-obese diabetic-severe combined immunodeficiency interleukin-2 receptor gamma chain-null (NSG) mice and established humanized mouse NPC-patient-derived xenograft (NPC-PDX) model successfully. "
01/01/2007 - "In this study, we constructed humanized nonobese diabetic/severe combined immunodeficiency (NOD/SCID)/interleukin-2 receptor gamma-chain knockout (IL2Rgamma(null)) (hNOG) mice by transplanting human cord blood-derived hematopoietic stem cells that eventually developed into human B cells, T cells, and other monocytes/macrophages and 4 dendritic cells associated with the generation of lymphoid follicle-like structures in lymphoid tissues. "
01/01/2022 - "Considering the absence of high-quality resources of immunodeficient rats, we used the CRISPR/Cas9 genome editing system to knock out the interleukin-2 receptor gamma chain gene (Il2rg) in F344/Jcl rats-alone or together with recombination activating gene 2 (Rag2)-to create a high-quality bioresource that researchers can freely use: severe combined immunodeficiency (SCID) rats. "
07/01/2015 - "Severe combined immunodeficiency (SCID) is most frequently caused by mutations in the cytokine receptor common gamma chain, CD132, encoded by the X-linked gene, IL2RG. "
06/01/2014 - "To prepare the relatively human bone marrow environment in mice, we generated nonobese diabetic/severe combined immunodeficiency/interleukin-2 receptor gamma chain null (NOG) mice expressing human Jagged1 (hJ1) in an osteoblast-specific manner (hJ1-NOG mice) to examine whether Notch signaling induced by hJ1 mediates hHSC proliferation and/or maintenance in mice. "
3. X-Linked Combined Immunodeficiency Diseases (X Linked Severe Combined Immunodeficiency)
4. Infections
5. Severe combined immunodeficiency due to adenosine deaminase deficiency

Related Drugs and Biologics

1. Cytokine Receptors (Cytokine Receptor)
2. Adenosine Deaminase
3. Janus Kinase 3
4. Hepatocyte Nuclear Factors
5. Intercellular Signaling Peptides and Proteins (Growth Factors)
6. Nonsense Codon (Nonsense Mutation)
7. Cytoplasmic and Nuclear Receptors (Nuclear Receptors)
8. Interleukin-2 Receptors (IL 2 Receptor)
9. Transcription Factors (Transcription Factor)
10. Messenger RNA (mRNA)

Related Therapies and Procedures

1. Heterologous Transplantation (Xenotransplantation)
2. Intravenous Injections