Asthenozoospermia

A condition in which the percentage of progressively motile sperm is abnormally low. In men, it is defined as <25% rapid motility or <50% progression in a semen sample (World Health Organization, 1992).

Networked: 226 relevant articles (15 outcomes, 40 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Oligospermia (Oligozoospermia)
2.	Male Infertility (Male Sterility)
3.	Infertility (Sterility)
4.	Hyperprolactinemia
5.	Chromosome Aberrations (Chromosome Abnormalities)

Experts

1.	Balercia, Giancarlo: 9 articles (06/2015 - 01/2004)
2.	Vignini, Arianna: 6 articles (06/2015 - 05/2009)
3.	Buldreghini, Eddi: 6 articles (06/2015 - 05/2009)
4.	Lenzi, Andrea: 6 articles (06/2015 - 06/2004)
5.	Tiano, Luca: 4 articles (06/2015 - 11/2005)
6.	Cai, Zhiming: 3 articles (01/2016 - 01/2011)
7.	Mazzanti, Laura: 3 articles (06/2015 - 09/2010)
8.	Salvolini, Eleonora: 3 articles (11/2014 - 03/2012)
9.	Di Primio, Roberto: 3 articles (11/2014 - 03/2012)
10.	Lucarini, Guendalina: 3 articles (11/2014 - 03/2012)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Asthenozoospermia:

1.	Kallikreins (Kallikrein)IBA 01/01/1985 - "Infertile men with sperm count below 20 X 10(6)/ml had greater improvement in sperm count than men with sperm count over 20 X 10(6)/ml. This study emphasizes that kallikrein is a relatively good drug for restoring sperm motility in idiopathic oligoasthenozoospermia and asthenozoospermia." 01/01/1985 - "A randomised group of 75 men with idiopathic oligoasthenozoospermia and asthenozoospermia were subjected to control study with kallikrein. " 01/01/1992 - "An application of Kallikrein in the swim-up preparation resulted in a higher motility in patients with asthenozoospermia, whereas the patients belonging to the group of oligoasthenozoospermia showed a lower progressive motility compared to the control. " 01/01/1991 - "While the groups normo-, oligo-, and asthenozoospermia reached a higher fertilizing capacity under Kallikrein-treatment (probability of error 2.5%), a Kallikrein application in case of oligo-asthenozoospermia had no significant influence on fertilizing capacity. " 10/13/1989 - "147 patients with isolated asthenozoospermia treated by means of 600 IU kallikrein daily showed a resultant significant elevation (p less than 0.002) in sperm motility only. "
2.	coenzyme Q10 (CoQ10)IBA 03/01/2010 - "CoQ(10) has been found to improve sperm count and motility on asthenozoospermia. " 09/01/2011 - "After the first in vitro observations CoQ(10) was administered to infertile patients affected by idiopathic asthenozoospermia, originally in an open label study and then in three randomized placebo-controlled trials; doses were around 200-300 mg/day and treatment lasted 6 months. " 05/01/2009 - "Coenzyme Q10 treatment in infertile men with idiopathic asthenozoospermia: a placebo-controlled, double-blind randomized trial." 09/01/2011 - "Administration of CoQ(10) may play a positive role in the treatment of asthenozoospermia, possibly related to not only to its function in the mitochondrial respiratory chain but also to its antioxidant properties. " 11/01/2005 - "Finally, the effect of coenzyme Q10 was evaluated in the treatment of asthenozoospermia. "
3.	UbiquinoneIBA 01/01/2004 - "Coenzyme Q(10) supplementation in infertile men with idiopathic asthenozoospermia: an open, uncontrolled pilot study." 05/01/2009 - "The exogenous administration of coenzyme Q(10) increases the level of the same and ubiquinol in semen and is effective in improving sperm kinetic features in patients affected by idiopathic asthenozoospermia." 01/01/2004 - "To clarify a potential therapeutic role of coenzyme Q(10) (CoQ(10)) in infertile men with idiopathic asthenozoospermia. " 07/01/2009 - "In conclusion, the exogenous administration of CoQ10 increases both ubiquinone and ubiquinol levels in semen and can be effective in improving sperm kinetic features in patients affected by idiopathic asthenozoospermia."
4.	ubiquinolIBA 05/01/2009 - "The exogenous administration of coenzyme Q(10) increases the level of the same and ubiquinol in semen and is effective in improving sperm kinetic features in patients affected by idiopathic asthenozoospermia." 07/01/2009 - "In conclusion, the exogenous administration of CoQ10 increases both ubiquinone and ubiquinol levels in semen and can be effective in improving sperm kinetic features in patients affected by idiopathic asthenozoospermia."
5.	Carnitine (L-Carnitine)FDA LinkGeneric 05/01/2010 - "L-carnitine, capable of significantly improving sperm motility and raising the rate of pregnancy, is a safe and effective therapeutic option for asthenozoospermia." 05/01/2010 - "[L-carnitine: safe and effective for asthenozoospermia]." 05/01/2010 - "The authors explored the clinical effect of L-carnitine for infertile males with asthenozoospermia. " 02/01/2005 - "To clarify the role of carnitine supplementation in idiopathic asthenozoospermia and to look for a rationale for its use in asthenozoospermic patients. " 05/01/1994 - "L-carnitine in idiopathic asthenozoospermia: a multicenter study. "
6.	TamoxifenFDA LinkGeneric 01/01/1990 - "Because of the good results achieved with tamoxifen in the treatment of oligozoospermia and with kallikrein in the treatment of asthenozoospermia, a randomized study of the combined treatment of oligoasthenozoospermia suggested itself. "
7.	Clomiphene (Clomifene)FDA LinkGeneric 10/01/2001 - "In those men whose seminal vesicle function improved after clomiphene treatment, a reduction in the prevalence of asthenozoospermia from 50 to 28.6% (z=3.10, p < 0.002) was observed whereas in those whose seminal vesicles did not respond to clomiphene the prevalence of asthenozoospermia was not reduced (z=1.05; p: NS). " 10/01/2001 - "Asthenozoospermia improves with clomiphene treatment if seminal vesicle function improves after treatment." 05/01/1980 - "76 men with idiopathic oligozoospermia mostly in addition to terato-asthenozoospermia, whose FSH level was in the middle or below the middle of the normal range, were treated with 50 mg clomiphene citrate daily for three months. " 03/01/1984 - "The effects of TSUMURA HACHIMIJIOHGAN (TJ-7) and TSUMURA NINJINTOH (TJ-32) on patients with the complaint of male sterility due to both or either oligozoospermia or asthenozoospermia were evaluated in comparison with the effects of clomiphene citrate. "
8.	Aspartic Acid (Aspartate)FDA Link 06/01/2015 - "Protective effects of coenzyme Q10 and aspartic acid on oxidative stress and DNA damage in subjects affected by idiopathic asthenozoospermia." 03/01/1979 - "Analytical data indicate that there were differences in the amino acid composition between oligo- or azoospermia and terato- or asthenozoospermia by aspartic acid, glutamic acid, threonine, glycine, alanine and isoleucine."
9.	Sulpiride (neogama)IBA 01/01/2013 - "He was diagnosed with oligozoospermia, asthenozoospermia and hyperprolactinemia probably induced by sulpiride for depression, because semen quality gradually improved after cessation of sulpiride administration. "
10.	Ketotifen (Ketotifene)FDA Link 11/01/1986 - "Treatment of idiopathic oligo- and asthenozoospermia by the mast cell blocker Ketotifen leads to a very moderate, but statistical significant improvement of sperm count and sperm motility. " 11/01/1986 - "The use of ketotifen, a mast cell blocker, for treatment of oligo- and asthenozoospermia."

Therapies and Procedures

1.	Aftercare (After-Treatment) 01/01/1981 - "They all gave improved findings, which were most unambiguous with regard to the number of spermia.--Findings were at least temporarily normal after treatment in 58 per cent of the patients with asthenozoospermia. " 03/01/2003 - "Although no histopathologic lesions or significant changes in the quantitative histologic examination were observed, semen quality examination revealed transient oligospermia (60, 90, 120, and 240mg/kg groups), teratozoospermia (120 and 240mg/kg groups), and asthenozoospermia (240mg/kg group), which returned to normal by the 6th (60 and 90mg/kg groups), 7th (120mg/kg group), or 8th week after treatment (240mg/kg group). " 09/01/1982 - "When comparing semen analyses done before and after treatment with M., a small but distinct reduction of hyperspermia as well as an augmentation of hypospermia were evident, an increase of sperm density in oligozoospermia grade I (20-40 kx 10(6) sperm/ml) was revealed, and an improvement of sperm motility in asthenozoospermia was seen. " 10/01/2001 - "Asthenozoospermia improves with clomiphene treatment if seminal vesicle function improves after treatment." 02/01/2000 - "Changes in plasma testosterone and testicular transferrin concentration, testicular histology and semen quality after treatment of testosterone-depot plus PMSG to 3 dogs with asthenozoospermia."
2.	Contraception (Birth Control) 01/01/2015 - "Thus, this study provides the first preliminary insight into the mechanism leading to the reduced CRISP2 expression in asthenozoospermia, offering a potential therapeutic target for treating male infertility or for male contraception."
3.	Oral Administration 05/01/1994 - "The authors conclude that oral administration of L-carnitine may improve sperm quality at least in patients with idiopathic asthenozoospermia." 05/01/1980 - "Pentoxifylline (BL 191) by oral administration in the treatment of asthenozoospermia." 04/01/1980 - "31 men with idiopathic oligozoospermia and 23 men with idiopathic asthenozoospermia were treated three months by oral administration of daily 600 units kallikrein. "
4.	Vasectomy (Vas Occlusion) 04/01/1996 - "The mean concentration of S-Tf-R in cases with normozoospermia was 10.4 IU/ml (95% confidence interval: 9.5-11.3) and it was significantly lower in patients with oligozoospermia (6.6, 95% CI: 5.8-7.5, P < 0.001), asthenozoospermia (8.5, 95% CI: 5.5-10.7, P < 0.05), azoospermia of primary testicular origin (7.9, 95% CI: 6.1-9.6, P<0.05) and post-vasectomy samples (5.9, 95% CI: 5.4-6.9, P < 0.001). " 07/01/1995 - "Also the mean (+/- SD) neutral alpha-glucosidase activity in patients with asthenozoospermia (11.7 +/- 9.2) oligozoospermia (11.3 +/- 7.2), and post vasectomy azoospermia (5.3 +/- 3.4) was significantly (p < .05) less than ejaculate from controls (21.2 +/- 14). "
5.	Chinese Traditional Medicine (Traditional Chinese Medicine) 02/01/2013 - "To determine the expression of CatSper1 channel in epididymal spermatozoa in a rat model of asthenozoospermia, induced by cyclophosphamide (CP), and further examine the effects of soluble granules of Sheng-Jing-San (SJS), a traditional Chinese medicine recipe, on CatSper1 expression and sperm motility in the CP-induced asthenozoospermic rats. " 02/01/2013 - "Based on the differential types in traditional Chinese medicine, 121 asthenozoospermia patients received at our clinic of andrology were divided into groups A (kidney-yin deficiency), B (kidney-yang deficiency) and C (spleen and kidney deficiency), and treated with Yougui Decoction plus Wuziyanzong Pills, Jinkuishenqi Pills plus Wuziyanzong Pills, and Shizi Decoction plus Liujunzi Decoction, respectively, all given once daily for 4 weeks. "