Lethargy

A general state of sluggishness, listless, or uninterested, with being tired, and having difficulty concentrating and doing simple tasks. It may be related to DEPRESSION or DRUG ADDICTION.

Networked: 1425 relevant articles (62 outcomes, 47 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Fatigue
2.	Vomiting
3.	Anorexia
4.	Diarrhea
5.	Ataxia (Dyssynergia)

Experts

1.	Akhondzadeh, Shahin: 5 articles (04/2020 - 02/2010)
2.	Klein-Schwartz, Wendy: 5 articles (01/2018 - 01/2005)
3.	Adelman, James S: 4 articles (01/2019 - 12/2010)
4.	Mohammadi, Mohammad-Reza: 4 articles (07/2014 - 02/2010)
5.	Harden, Lois M: 4 articles (06/2013 - 03/2009)
6.	Araujo, Andre B: 3 articles (10/2008 - 11/2007)
7.	Clark, Richard V: 3 articles (10/2008 - 11/2007)
8.	Esche, Gretchen R: 3 articles (10/2008 - 11/2007)
9.	McKinlay, John B: 3 articles (10/2008 - 11/2007)
10.	Travison, Thomas G: 3 articles (10/2008 - 11/2007)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Lethargy:

1.	Glucose (Dextrose)FDA LinkGeneric 07/09/2021 - "Neonatal hypoglycaemia, defined as either capillary or venous glucose ≤ 2.0 mmol/L and/or clinical signs of neonatal hypoglycaemia requiring oral or intravenous dextrose (lethargy, abnormal feeding behaviour or seizures). " 01/01/1985 - "Reductions of plasma glucose from 7.7 mM (control) to 2.5-1.7 mM (moderate hypoglycemia associated with decreased motor activity) or 1.5 mM (severe hypoglycemia with lethargy progressing to stupor) decreased glucose concentrations in the cerebral cortex, striatum, and hippocampus to less than 10% of control. " 11/01/2021 - "Six triggers (serum glucose >110 mg/dL, abrupt cessation of medication, oversedation/lethargy, hypotension, adverse reaction recorded and constipation) accounted for 69.8% of the ADEs identified. " 09/11/2004 - "In comparison with 1993-1994, there were less frequent lethargy or dehydration; lower average serum-glucose values, a better blood pH and less frequent ketonuria at the time of diagnosis. " 01/01/2015 - "Hypoglycaemia caused characteristic behavioural alterations including lethargy, dullness, sitting quietly but appearing alert, followed by aesthesia and then muscular weakness with characteristic postural changes starting from drooping of head and torticollis, Rabbits recovered following glucose therapy. "
2.	CreatinineIBA 09/13/2013 - "After adjustment for covariates, higher creatinine-corrected urinary concentrations of diethylphosphate metabolites were associated with improved attention and reduced lethargy and hypotonia in young infants. " 04/21/1993 - "Treatment was discontinued in 28 patients because of dose-limiting toxicity consisting of a syndrome of malaise, fatigue, and lethargy; recurrent reduction in creatinine clearance of 50% or more; or axonal neuropathy. " 07/01/2007 - "In contrast, at the dose of 150 mg/kg, adverse events such as lethargy, weight loss, and elevated BUN (p < 0.01) and serum creatinine (p < 0.001) levels were recorded. " 01/01/1991 - "Severe confusion and lethargy associated with rising creatinine developed in 2 patients. " 01/01/2020 - "The data of four relevant syndromic components: elevated serum creatinine concentration, vomiting, anorexia, and lethargy from July 28, 2006 to May 31, 2007 were prospectively analyzed using the PDOR algorithm. "
3.	Omega-3 Fatty Acids (Omega 3 Fatty Acids)IBA 01/01/2017 - "Meta-analysis showed that supplementation of omega 3 fatty acids improved hyperactivity (difference in means =-2.692, 95% confidence interval [CI] =-5.364 to -0.020, P=0.048, studies =4, n=109), lethargy (difference in means =-1.969, 95% CI =-3.566 to -0.372, P=0.016, studies =4, n=109), and stereotypy (difference in means =-1.071, 95% CI =-2.114 to -0.029, P=0.044, studies =4, n=109). " 01/01/2017 - "Our preliminary meta-analysis suggests that supplementation of omega 3 fatty acids may improve hyperactivity, lethargy, and stereotypy in ASD patients. " 01/01/2017 - "Supplementation of omega 3 fatty acids may improve hyperactivity, lethargy, and stereotypy in children with autism spectrum disorders: a meta-analysis of randomized controlled trials." 04/01/1997 - "Dietary n-3 fatty acids prevented fever and attenuated the decrease in body weight caused by LPS but did not affect the LPS-induced lethargy and anorexia. " 01/01/2023 - "(Add-on) treatment with prednisolone, pregnenolone, celecoxib, minocycline, NAC, SFN, and/or omega-3 fatty acids was also associated with a significantly higher improvement in other symptoms, such as irritability, hyperactivity, and/or lethargy when compared with placebo. "
4.	Insulin (Novolin)FDA Link 01/01/1989 - "Each of the possible causes of lethargy or somnolence needs to be evaluated with the understanding that a multitude of factors may be present in the patient whose condition precludes a thorough history; the depressed diabetic may have taken an overdose of medications in addition to his insulin. " 07/01/1983 - "Lethargy and vomiting after the insulin thawed." 01/01/1977 - "Hypothyroidism was diagnosed after a 3 month history of lethargy, constipation, dryness of skin and decreasing insulin requirement to 10 units NPH per day. " 01/01/2022 - "A 58-year-old male with a history of hypertension and non-insulin dependent type 2 diabetes mellitus (DM) was brought in by ambulance and admitted to the intensive care unit for weakness, lethargy, and altered mental status and was found to be hypotensive and subsequently diagnosed with severe diabetic ketoacidosis (DKA). " 06/01/1987 - "[Regulation of endocrine pancreas secretions (insulin and glucagon) during the periodic lethargy-waking cycle of the hibernating mammal]."
5.	Antidepressive Agents (Antidepressants)IBA 01/01/2009 - "Ninety-nine percent of those with sleep problems also reported daytime symptoms including lack of concentration, exhaustion and lethargy, no energy and feeling sleepy; 40% admitted napping during the day; 59% indicated that poor sleep greatly affected their quality of life (QOL); 34% considered it to be "very distressing"; 69% of respondents were taking antidepressant medication at the time (44% said it improved their sleep, 56% said it had no effect or worsened their sleep); 69% had sought extra treatment for their sleep problems. " 01/01/2022 - "These substances have an impact on the human body in many ways, including having a thymoleptic effect (reducing emotional stress, irritability, anxiety, eliminating lethargy, apathy, melancholy, anxiety) and regulating cognitive activity. " 04/01/2011 - "A comparison of the associated symptoms for each of the antidepressants found that the prevalence of the combined factor of fatigue, drowsiness, tiredness or lethargy ranged from 6.4±0.8% down to 2.9±0.15% of the mentions, where the S.E. " 07/01/2010 - "Serotonergic antidepressant drugs are sometimes associated with a distinct discontinuation syndrome characterized by dizziness, weakness, nausea, headache, lethargy, insomnia, anxiety, poor concentration, and paresthesias. " 02/14/1992 - "Various classes of antidepressant drugs with distinct pharmacologic actions are differentially effective in the treatment of classic melancholic depression--characterized by pathological hyperarousal and atypical depression--associated with lethargy, hypersomnia, and hyperphagia. "
6.	Risperidone (Risperdal Consta)FDA LinkGeneric 08/01/2002 - "Risperidone was also associated with significantly greater improvement than placebo on all other Nisonger Child Behavior Rating Form subscales at endpoint, as well as on the Aberrant Behavior Checklist subscales for irritability, lethargy/social withdrawal, and hyperactivity; the Behavior Problems Inventory aggressive/destructive behavior subscale; a visual analogue scale of the most troublesome symptom; and the Clinical Global Impression change score. " 01/01/2021 - "In conclusion, it was possible to suggest the efficacy of risperidone for the treatment of lethargy and inadequate speech. " 02/01/2016 - "Parents may expect benefits of risperidone on irritability and lethargy with moderate to severe symptoms of ASD. " 02/01/2016 - "Greater magnitudes of the differences between risperidone and placebo were observed from moderate to very severe baseline severity on irritability and lethargy. " 01/01/2021 - "Although risperidone is effective for the treatment of lethargy and inadequate speech, concerns about the association between weight gain, waist circumference and risperidone require a need for evaluation of the risk-benefit ratio in its use. "
7.	Prednisolone (Predate)FDA LinkGeneric 11/01/1999 - "Marked improvement of the arthralgia, fever and lethargy was obtained with oral prednisolone. " 04/15/2003 - "An 11-year-old cat with a history of renal transplantation and treatment with cyclosporine and prednisolone was examined because of vomiting, diarrhea, inappetence, lethargy, and weight loss. " 01/01/2023 - "(Add-on) treatment with prednisolone, pregnenolone, celecoxib, minocycline, NAC, SFN, and/or omega-3 fatty acids was also associated with a significantly higher improvement in other symptoms, such as irritability, hyperactivity, and/or lethargy when compared with placebo. "
8.	Celecoxib (Celebrex)FDA Link 01/01/2013 - "By week 10, patients in the celecoxib group showed significantly greater improvement in the Irritability (P < 0.001), Lethargy/Social Withdrawal (P < 0.001), and Stereotypic Behavior (P < 0.00) but not in Hyperactivity/Noncompliance (P = 0.202) and Inappropriate Speech (P = 0.802) subscales than the placebo group. " 01/01/2023 - "(Add-on) treatment with prednisolone, pregnenolone, celecoxib, minocycline, NAC, SFN, and/or omega-3 fatty acids was also associated with a significantly higher improvement in other symptoms, such as irritability, hyperactivity, and/or lethargy when compared with placebo. "
9.	Phenobarbital (Luminal)FDA Link 12/01/2021 - "A 4-year-old neutered male St. Bernard-mastiff crossbred dog showed clinical signs of lethargy and anorexia after being administered phenobarbital for the treatment of idiosyncratic seizures. " 07/01/1990 - "A 28-day-old infant developed lethargy, hypotonia, and hypothermia following a phenobarbital overdose secondary to a pharmacist's error. " 01/01/2017 - "The most common adverse events were lethargy, inappetence and ataxia, with no difference in incidence between levetiracetam and phenobarbital. " 05/01/2012 - "Ataxia, lethargy, and polydipsia were greater at 1 month for phenobarbital-treated dogs; vomiting was greater for bromide-treated dogs at 1 month and study end. " 10/01/1977 - "A placebo-controlled, randomized, double-blind, parallel group study in hospital and general practice has shown that a combination of belladonna alkaloids, ergotamine tartrate, and phenobarbitone (Bellergal) was effective in treating troublesome symptoms of the premenstrual syndrome of which fatigue, tender breasts, nervousness, irritability, lethargy and listlessness were improved to a statistically significant degree. "
10.	Propranolol (Inderal)FDA LinkGeneric 01/01/2018 - "Although there were more short- or long-term general adverse effects (such as severe diarrhoea, lethargy, and loss of appetite) in the oral propranolol group, there was no evidence of a difference between groups (RR 7.00, 95% CI 0.40 to 123.35; 1 study; 26 participants; very low-quality evidence). " 06/15/2016 - "A seven-month-old infant (weight, 6.1 kg) was admitted to a hospital emergency department with lethargy and bradycardia after an unintentional overdose of propranolol suspension, which had been prescribed several days previously for treatment of a scalp hemangioma. " 09/01/2023 - "There is no standardized protocol; however, drug discontinuation, beta-blockers (specifically propranolol), and cholestyramine effectively manage overdose when needed, with most cases resolving independently without medical intervention.  Here, we present the case of a 26-year-old female with a history of supraventricular tachycardia, anxiety, depression, and Hashimoto thyroiditis who was accidentally overprescribed LT (300 mcg for one and a half months) that resulted in symptoms of lethargy, tremors, body temperature dysregulation, orthostatic hypotension, and diarrhea. This case, with limited evidence, suggests that excessive LT exacerbated the patient's underlying psychiatric symptoms, encouraging suicidal ideation." 02/01/1987 - "Withdrawal from the trial because of lethargy and fatigue was significantly greater among patients on methyldopa and propranolol than among those receiving captopril. "

Therapies and Procedures

1.	Therapeutics 01/01/2012 - "Lethargy improved within 3 h of intravenous therapy initiation. " 09/01/1998 - "Mood swings, lethargy and vaginal dryness improved rapidly in the initial 3 months of therapy. " 06/01/2016 - "A 37-yr-old captive common hippopotamus (Hippopotamus amphibius) developed lethargy and decline in mobility that progressed to death, despite supportive therapy. " 03/01/1994 - "Lethargy during treatment ceased with termination of therapy. " 01/01/1994 - "The lethargy was continued for about 10 days despite the therapy was interrupted, and then he gradually became alert. "
2.	Drug Therapy (Chemotherapy) 01/24/2014 - "Here we report on the case of a woman with recurrent breast cancer, undergoing weekly chemotherapy, with lethargy as a major symptom. " 03/01/2018 - "F-FDG PET/CT scan obtained after the first cycle of chemotherapy, complicated by acute kidney injury, hypertension, tumor lysis syndrome, and lethargy with focal neurological symptoms, showed a favorable marrow and lymph node response but increased FDG uptake in the bilateral frontal and occipital cortical/subcortical regions. " 06/15/2004 - "The most frequently observed symptoms experienced during or shortly following chemotherapy were neurosensory loss, lethargy, nausea, vomiting, and alopecia. " 04/01/1975 - "A syndrome of fever, lethargy, irritability and rash occurred in patients undergoing surgery, irradiation and chemotherapy for Wilms' tumor. " 12/01/2003 - "An 11-month-old girl with B-cell leukemia/lymphoma developed profound lethargy due to severe lactic acidosis during chemotherapy and total parenteral nutrition (TPN). "
3.	Aftercare (After-Treatment) 01/01/2020 - "Both patients displayed minor lethargy during the first 36 h after treatment and localized treatment-site discomfort was apparent over the first 3-5 days. " 04/02/2021 - "Although no further significant differences between the groups using ANCOVA and a linear regression model including all groups were detected, severe meconium staining in more than 10% of piglets was observed in group II and IV. Moreover, piglets of group IV showed oedematous and haemorrhagic umbilical cords, lethargy and anoxia after treatment, and intra-partum deaths were recorded.The" 01/01/2015 - "After treatment, neck masses persisted in 48.4% of patients and complaints of lethargy and fever in 6.5%. " 01/01/2020 - "He developed jaundice, drowsiness, lethargy, and anorexia after treatment. " 11/01/2006 - "After treatment, 8 of the 12 pigeons exhibited signs of anorexia, lethargy, and dehydration; these birds died within 2 d after the onset of clinical signs. "
4.	Injections 01/01/2017 - "PFO66 resulted in tachypnea and lethargy for ~1 minute following injections. " 07/01/1993 - "The seroconversion rates measured by ELISA were 98.3% (59/60) at months 1 and 6 and 100% at month 7. Sixty-one per cent (109/180) of the documented injections were followed by local symptoms, essentially mild soreness at the site of injection; and 22.2% (40/180) by minor general symptoms including malaise, fatigue and lethargy. " 07/01/1982 - "After i.c.v. injections, the low frequency EEG during the lethargy and ataxia were not evident. " 10/15/1993 - "After the injections were abruptly discontinued, the horse developed anorexia, lethargy, weight loss, and bilateral forelimb lameness. " 01/01/2022 - "In both animals and humans, inflammatory stimuli - especially infections and endotoxin injections - cause "sickness behaviors," including lethargy, malaise, and low mood. "
5.	Palliative Care (Palliative Therapy) 10/01/2016 - "Killing the Pain and Battling the Lethargy: Misleading Military Metaphors in Palliative Care." 04/01/2014 - "Fighting insomnia and battling lethargy: the yin and yang of palliative care." 01/01/2021 - "As dialysis has variable effects in ameliorating symptoms, palliative care may be needed to manage symptoms such as pain, fatigue/lethargy, anorexia, and anxiety/depression. " 10/01/2018 - "The pediatric palliative care screening instrument pilot provides a centralized instrument to document and quantify a patient's symptom profile, giving registered nurses the opportunity to objectively communicate and track a patient's need for improved symptom management care within the areas of pain, secretions, dyspnea, intractable seizures, nausea, vomiting, constipation, diarrhea, anorexia, cachexia, sleep disturbance, lethargy, anxiety, depression, and/or agitation. "