Adrenomedullin

A 52-amino acid peptide with multi-functions. It was originally isolated from PHEOCHROMOCYTOMA and ADRENAL MEDULLA but is widely distributed throughout the body including lung and kidney tissues. Besides controlling fluid-electrolyte homeostasis, adrenomedullin is a potent vasodilator and can inhibit pituitary ACTH secretion.

Also Known As:

Networked: 1691 relevant articles (62 outcomes, 265 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Kangawa, Kenji: 59 articles (06/2013 - 02/2002)
2.	Kitamura, Kazuo: 48 articles (11/2022 - 04/2002)
3.	Struck, Joachim: 38 articles (06/2022 - 08/2004)
4.	Bergmann, Andreas: 36 articles (06/2022 - 08/2004)
5.	Martínez, Alfredo: 29 articles (01/2022 - 04/2002)
6.	Wang, Ping: 28 articles (08/2021 - 04/2002)
7.	Nishikimi, Toshio: 28 articles (01/2018 - 02/2002)
8.	Kangawa, K: 28 articles (07/2004 - 01/2000)
9.	Eto, Tanenao: 23 articles (08/2012 - 04/2002)
10.	Hartmann, Oliver: 20 articles (06/2022 - 05/2010)

Related Diseases

1.	Sepsis (Septicemia) 01/01/2018 - "Adrenomedullin (ADM) is an important regulator of endothelial barrier function and vascular tone, and may represent a novel treatment target in sepsis. " 12/01/2020 - "Adrenomedullin and Its Possible Role in Improved Survival in Female Patients with Sepsis: A Study in the South East Asian Region. " 12/01/2020 - "Adrenomedullin and Its Possible Role in Improved Survival in Female Patients with Sepsis: A Study in the South East Asian Region." 12/01/2020 - "Treatment with a non-neutralizing monoclonal anti-adrenomedullin antibody showed improvement in murine sepsis models. " 01/01/2006 - "Pro-adrenomedullin (proADM) is helpful for individual risk assessment and outcome prediction in sepsis. "
2.	Reperfusion Injury 12/01/2014 - "Adrenomedullin-2/intermedin(8-47) ameliorates early ischemia/reperfusion injury in mouse lungs by protecting the integrity of the blood-air barrier and by potently reducing leukocyte influx into the alveolar space. " 07/01/2009 - "Adrenomedullin ameliorates ischemia reperfusion injury in rat livers." 08/01/2006 - "Exogenous administration or transfection of adrenomedullin (AM) affords protection against ischaemia-reperfusion injury. " 12/01/2014 - "Here, we test the hypothesis that adrenomedullin-2/intermedin(8-47) protects mouse lungs from ischemia/reperfusion injury in vivo. " 12/01/2014 - "Low-dose adrenomedullin-2/intermedin(8-47) reduces pulmonary ischemia/reperfusion injury."
3.	Myocardial Ischemia (Ischemic Heart Diseases) 04/01/2000 - "[Changes and cardiac protective effects of adrenomedullin during myocardial ischemia-reperfusion period]." 01/01/2003 - "The authors determined the changes in adrenomedullin (AM) expression in the coronary circulation of patients with ischemic heart disease who underwent coronary stent implantation. " 03/01/2009 - "Because adrenomedullin (AM) promotes Akt phosphorylation and attenuates myocardial ischemia/reperfusion injury, we tested the hypothesis that pretreatment with AM before HT could restore depressed Akt activation and cardiac HSP72 expression, thereby enhancing protection against ischemia/reperfusion injury in this model. " 01/01/2022 - "By evaluating the relationship between adrenomedullin (ADM) and myocardial ischemic T wave changes, the clinical value of circulating ADM as a predictor of myocardial ischemia in patients with lung cancer is confirmed. " 01/01/1999 - "To explore the role of adrenomedullin (ADM) in pathophysiology of ischemic heart disease, we investigated the effects of hypoxia on the production and secretion of ADM in cultured human coronary artery endothelial cells. "
4.	Heart Failure 09/16/1997 - "Adrenomedullin reduced ventricular preload and afterload and improved cardiac output in sheep with congestive heart failure. " 02/01/2016 - "Bioactive adrenomedullin concentrations at the time of ED evaluation for acute heart failure were predictive of clinically important 30-day outcomes, suggesting that bio-ADM is a promising prognostic marker for further study." 12/01/2013 - "The aim of this study was to evaluate the long-term prognostic utility of mid-region prohormone adrenomedullin (MR-proADM) in stable outpatients with heart failure (HF). " 04/01/2009 - "Our previous study showed elevation of plasma adrenomedullin (ADM) during static handgrip in patients with heart failure (HF). " 11/01/2006 - "Our previous study showed that static handgrip caused increases in the plasma adrenomedullin (ADM) both in patients with heart failure (HF) and healthy subjects. "
5.	Pulmonary Hypertension 12/01/2001 - "To investigate the synthesis and release of adrenomedullin (AM) of lung tissue in rats on hypoxic pulmonary hypertension (HPH) and study its mechanism and significance in the pathogenesis process of HPH. " 04/01/2014 - "Previous research showed that adrenomedullin (ADM) mitigates the development of pulmonary hypertension. " 12/01/2007 - "Exogenous adrenomedullin prevents and reverses hypodynamic circulation and pulmonary hypertension in ovine endotoxaemia." 11/01/2007 - "[Changes of adrenomedullin 2/intermedin in the lung of rats with chronic hypoxic pulmonary hypertension]." 04/25/2007 - "[Changes of intermedin/adrenomedullin 2 and its receptors in the right ventricle of rats with chronic hypoxic pulmonary hypertension]."

Related Drugs and Biologics

1.	Peptides (Polypeptides)
2.	Carrier Proteins (Binding Protein)
3.	Atrial Natriuretic Factor (ANF)
4.	Vasodilator Agents (Vasodilators)
5.	Nitric Oxide (Nitrogen Monoxide)
6.	Adrenomedullin Receptors
7.	Hormones (Hormone)
8.	Salts
9.	Nitric Oxide Synthase (NO Synthase)
10.	Biomarkers (Surrogate Marker)

Related Therapies and Procedures

1.	Intravenous Infusions
2.	Therapeutics
3.	Ligation
4.	Critical Care (Surgical Intensive Care)
5.	Percutaneous Coronary Intervention